ReviewHearing research2015
Auditory midbrain implant: research and development towards a second clinical trial.
Review in Hearing research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 65 citations in OpenAlex.
- Stimulation-stability and preclinical bench testing of a new auditory nerve interface.Bioelectronic medicine · 2026Article
- Stimulation-Stability and Preclinical Bench Testing of a New Auditory Nerve Interface.Research square · 2026Article
- From Physical Replacement to Biological Symbiosis: Evolutionary Paradigms and Future Prospects of Auditory Reconstruction Brain-Computer Interfaces.Micromachines · 2026Review
- Pilot Chronic Evaluation of a Slanted Electrode Array as an Auditory Nerve Implant.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026Article
- Focal thalamic infrared neural stimulation propagates dynamical transformations in auditory cortex.Journal of neural engineering · 2025Article
- The auditory nerve implant-concept and device description of a novel electrical auditory prosthesis.Bioelectronic medicine · 2025Review
- Characterization and closed-loop control of infrared thalamocortical stimulation produces spatially constrained single-unit responses.PNAS nexus · 2024Article
- Development of a feline model for preclinical research of a new translabyrinthine auditory nerve implant.Frontiers in neuroscience · 2024Article
- Spatially specific, closed-loop infrared thalamocortical deep brain stimulation.bioRxiv : the preprint server for biology · 2023Article
- Differential optogenetic activation of the auditory midbrain in freely moving behaving mice.Frontiers in systems neuroscience · 2023Article
- Treated large posterior fossa vestibular schwannoma and meningioma: Hearing outcome and willingness-to-accept brain implant for unilateral deafness.Laryngoscope investigative otolaryngology · 2022Article
- Design and optimization of auditory prostheses using the finite element method: a narrative review.Annals of translational medicine · 2022Review
- Spatiotemporal patterns of gene expression around implanted silicon electrode arrays.Journal of neural engineering · 2021Article
- Animal Models of Tinnitus Treatment: Cochlear and Brain Stimulation.Current topics in behavioral neurosciences · 2021Article
- Options and strategies for hearing restoration in pediatric neurofibromatosis type 2.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- Toward guiding principles for the design of biologically-integrated electrodes for the central nervous system.Journal of neural engineering · 2020Article
- Neural Modulation of the Primary Auditory Cortex by Intracortical Microstimulation with a Bio-Inspired Electronic System.Bioengineering (Basel, Switzerland) · 2020Article
- Interfacing with the nervous system: a review of current bioelectric technologies.Neurosurgical review · 2019Review
- Developing a hippocampal neural prosthetic to facilitate human memory encoding and recall.Journal of neural engineering · 2018Article
- Auditory and audio-visual processing in patients with cochlear, auditory brainstem, and auditory midbrain implants: An EEG study.Human brain mapping · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
The cochlear implant is considered one of the most successful neural prostheses to date, which was made possible by visionaries who continued to develop the cochlear implant through multiple technological and clinical challenges. However, patients without a functional auditory nerve or implantable cochlea cannot benefit from a cochlear implant. The focus of the paper is to review the development and translation of a new type of central auditory prosthesis for this group of patients that is known as the auditory midbrain implant (AMI) and is designed for electrical stimulation within the inferior colliculus. The rationale and results for the first AMI clinical study using a multi-site single-shank array will be presented initially. Although the AMI has achieved encouraging results in terms of safety and improvements in lip-reading capabilities and environmental awareness, it has not yet provided sufficient speech perception. Animal and human data will then be presented to show that a two-shank AMI array can potentially improve hearing performance by targeting specific neurons of the inferior colliculus. A new two-shank array, stimulation strategy, and surgical approach are planned for the AMI that are expected to improve hearing performance in the patients who will be implanted in an upcoming clinical trial funded by the National Institutes of Health. Positive outcomes from this clinical trial will motivate new efforts and developments toward improving central auditory prostheses for those who cannot sufficiently benefit from cochlear implants. This article is part of a Special Issue entitled <Lasker Award>.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.