ArticleInvestigative ophthalmology & visual science2015
Assessing age-related changes in the biomechanical properties of rabbit lens using a coaligned ultrasound and optical coherence elastography system.
Article in Investigative ophthalmology & visual science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed.
- In Vivo Safety Evaluation of Acoustic Radiation Force for Optical Coherence Elastography of the Crystalline Lens.Translational vision science & technology · 2025Article
- Air-pulse optical coherence elastography: how excitation angle affects mechanical wave propagation.Biomedical optics express · 2025Article
- Comparative analysis of rodent lens morphometrics and biomechanical properties.Frontiers in ophthalmology · 2025Article
- Compound Acoustic Radiation Force Impulse Imaging of Bovine Eye by Using Phase-Inverted Ultrasound Transducer.Sensors (Basel, Switzerland) · 2024Article
- Tissue, cellular, and molecular level determinants for eye lens stiffness and elasticity.Frontiers in ophthalmology · 2024Review
- Simultaneous Assessment of the Whole Eye Biomechanics Using Ultrasonic Elastography.IEEE transactions on bio-medical engineering · 2023Article
- Design of an Automatically Controlled Multi-Axis Stretching Device for Mechanical Evaluations of the Anterior Eye Segment.Bioengineering (Basel, Switzerland) · 2023Article
- Review
- The lens capsule significantly affects the viscoelastic properties of the lens as quantified by optical coherence elastography.Frontiers in bioengineering and biotechnology · 2023Article
- Article
- Imaging of Single Transducer-Harmonic Motion Imaging-Derived Displacements at Several Oscillation Frequencies Simultaneously.IEEE transactions on medical imaging · 2022Article
- Micron-scale hysteresis measurement using dynamic optical coherence elastography.Biomedical optics express · 2022Article
- Introduction to optical coherence elastography: tutorial.Journal of the Optical Society of America. A, Optics, image science, and vision · 2022Article
- EphA2 Affects Development of the Eye Lens Nucleus and the Gradient of Refractive Index.Investigative ophthalmology & visual science · 2022Article
- Advances in non-invasive biosensing measures to monitor wound healing progression.Frontiers in bioengineering and biotechnology · 2022Review
- Wave-based optical coherence elastography: The 10-year perspective.Progress in biomedical engineering (Bristol, England) · 2022Article
- Ultrahigh field MRI determination of water diffusion rates inQuantitative imaging in medicine and surgery · 2021Article
- In vivo human corneal natural frequency quantification using dynamic optical coherence elastography: Repeatability and reproducibility.Journal of biomechanics · 2021Article
- Feasibility of Harmonic Motion Imaging Using a Single Transducer: In Vivo Imaging of Breast Cancer in a Mouse Model and Human Subjects.IEEE transactions on medical imaging · 2021Article
- Ultrasound elastography for evaluating stiffness of the human lens nucleus with aging: a feasibility study.International journal of ophthalmology · 2021Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
purposeTo evaluate the capability of a novel, coaligned focused ultrasound and phase-sensitive optical coherence elastography (US-OCE) system to assess age-related changes in biomechanical properties of the crystalline lens in situ.
methodsLow-amplitude elastic deformations in young and mature rabbit lenses were measured by an US-OCE system consisting of a spectral-domain optical coherence tomography (OCT) system coaligned with a focused ultrasound system used to produce a transient force on the lens surface. Uniaxial compressional tests were used to validate the OCE data.
resultsThe OCE measurements showed that the maximum displacements of the young rabbit lenses were significantly larger than those of the mature lenses, indicating a gradual increase of the lens stiffness with age. Temporal analyses of the displacements also demonstrate a similar trend of elastic properties in these lenses. The stress-strain measurements using uniaxial mechanical tests confirmed the results obtained by the US-OCE system.
conclusionsThe results demonstrate that the US-OCE system can be used for noninvasive analysis and quantification of lens biomechanical properties in situ and possibly in vivo.
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