Evidence map›Paper›PMID 25613643›Full record

ArticleInfectious diseases and therapy2015

Medication Adherence and Health Outcomes of People Living with HIV Who Are Food Insecure and Prescribed Antiretrovirals That Should Be Taken with Food.

Seth C Kalichman, Christopher Washington, Tamar Grebler, Ginger Hoyt, Brandi Welles, Christopher Kegler, Moira O Kalichman, Chauncey Cherry

Open access · goldAbstract read
In one paragraph

Article in Infectious diseases and therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
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  7. 'We have goals but [it is difficult]'. Barriers to antiretroviral therapy adherence among women using alcohol and other drugs living with HIV in South Africa.Health expectations : an international journal of public participation in health care and health policy · 2022
    Article
  8. Article
  9. Article
  10. Observational
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  12. Article
  13. Food Insecurity and Unmet Needs Among Youth and Young Adults Living With HIV in the San Francisco Bay Area.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2019
    Article
  14. Article
  15. Article
  16. Article
  17. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Seth C KalichmanUniversity of Connecticut, Storrs, CT, 06269, USA, seth.k@uconn.edu.
Christopher Washington
Tamar Grebler
Ginger Hoyt
Brandi Welles
Christopher Kegler
Moira O Kalichman
Chauncey Cherry
University of Connecticut · US

Funding

Behavioral Intervention to Enhance HIV Test/TreatR01DA033067 · NIDA · UNIVERSITY OF CONNECTICUT STORRS · PI KALICHMAN, SETH C · 2012 to 2016
$3.3M
Influence of Food Insecurity on AdherenceR01AA021471 · NIAAA · UNIVERSITY OF CONNECTICUT STORRS · PI KALICHMAN, SETH C · 2013 to 2015
$941k
NIAAA NIH HHS R01 AA021471NIDA NIH HHS R01 DA033067
6 · The paper itself

Abstract

introductionFood insecurity is a well-established predictor of poor health outcomes. Antiretroviral therapies (ARTs) that should be taken with food to increase bioavailability may further challenge food insecure patients. This study examined factors associated with antiretroviral adherence and HIV viral suppression among people living with HIV who are food insecure and prescribed medications that require food.

methodsA community sample of 313 men and 105 women who experienced food insecurity in the previous month and were currently taking ART completed computerized interviews, urine screening for drug use, prospective biweekly unannounced pill count adherence assessments, and obtained their HIV viral load and CD4 cell counts from medical records.

resultsIndividuals taking ART regimens that should be taken with food were significantly more likely to be unemployed, were living longer with an HIV diagnosis, had lower CD4 cell counts, poorer HIV suppression, and endorsed more beliefs that taking medications was necessary for their health. Multivariable regression models controlling for potential confounding factors showed that receiving ART that requires food was significantly related to poorer ART adherence and unsuppressed HIV in this food insecure sample.

conclusionPeople living with HIV who are food insecure likely experience multiple facets of poverty that challenge their medication adherence, but food insecurity is the only such factor that is directly related to the pharmacokinetics of some antiretroviral medications. Achieving optimal treatment outcomes for HIV infection will require routine assessment of access to food when determining patient-tailored ART regimens.

Identifiers

PMID25613643
PMCPMC4363219
OpenAlexW2035632809

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.