Evidence map›Paper›PMID 25613594›Full record

ArticleAIDS and behavior2015

Comprehensive evaluation of caregiver-reported antiretroviral therapy adherence for HIV-infected children.

Rachel C Vreeman, Winstone M Nyandiko, Hai Liu, Wanzhu Tu, Michael L Scanlon, James E Slaven, Samuel O Ayaya, Thomas S Inui

Abstract read
In one paragraph

Article in AIDS and behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  16. Validation of an HIV/AIDS Stigma Measure for Children Living with HIV and Their Families.Journal of the International Association of Providers of AIDS Care
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rachel C VreemanChildren's Health Services Research, Department of Pediatrics, Indiana University School of Medicine, 410 W. 10th Street, HITS Suite 1000, Indianapolis, IN, 46202, USA, rvreeman@iu.edu.
Winstone M Nyandiko
Hai Liu
Wanzhu Tu
Michael L Scanlon
James E Slaven
Samuel O Ayaya
Thomas S Inui

Funding

Development of an Antiretroviral Therapy Adherence Measure for PediatricsK23MH087225 · NIMH · INDIANA UNIVERSITY INDIANAPOLIS · PI VREEMAN, RACHEL CHRISTINE · 2009 to 2013
$862k
NIMH NIH HHS 1K23MH087225NIMH NIH HHS K23 MH087225PEPFAR
6 · The paper itself

Abstract

For HIV-infected children, adherence to antiretroviral therapy (ART) is often assessed by caregiver report but there are few data on their validity. We conducted prospective evaluations with 191 children ages 0-14 years and their caregivers over 6 months in western Kenya to identify questionnaire items that best predicted adherence to ART. Medication Event Monitoring Systems(®) (MEMS, MWV/AARDEX Ltd., Switzerland) electronic dose monitors were used as external criterion for adherence. We employed a novel variable selection tool using the LASSO technique with logistic regression to identify items best correlated with dichotomized MEMS adherence (≥90 or <90 % doses taken). Nine of 48 adherence items were identified as the best predictors of adherence, including missed or late doses in the past 7 days, problems giving the child medicines, and caregiver-level factors like not being present at medication taking. These items could be included in adherence assessment tools for pediatric patients.

Indexed as

CaregiversDrug MonitoringParentsAdolescentAlkynesAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveBenzoxazinesChildChild, PreschoolCohort StudiesCyclopropanesFemaleHIV InfectionsHumansInfantAlkynesAnti-HIV AgentsBenzoxazinesCyclopropanesefavirenzNevirapine

Identifiers

PMID25613594
PMCPMC4393778

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.