ArticleInternational journal of epidemiology2015
Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium.
Open access · bronzeAbstract read
In one paragraph
Article in International journal of epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 4 pooled it
13.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 4 syntheses or guidelines pooled it, 156 citations in OpenAlex.
- Characteristics of cigarette smoking without alcohol consumption and laryngeal cancer: overall and time-risk relation. A meta-analysis of observational studies.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017Pooled it
- Does CYP2E1 RsaI/PstI polymorphism confer head and neck carcinoma susceptibility?: A meta-analysis based on 43 studies.Medicine · 2016Pooled it
- Is MDM2 SNP309 Variation a Risk Factor for Head and Neck Carcinoma?: An Updated Meta-Analysis Based on 11,552 Individuals.Medicine · 2016Pooled it
- Significant association between functional microRNA polymorphisms and head and neck cancer susceptibility: a comprehensive meta-analysis.Scientific reports · 2015Pooled it
- Risk of employment separation among workers with head and neck cancer: a longitudinal cohort study in Turin.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Genome-wide association study of never-smoking non-drinking young adults developing oral squamous cell carcinoma.BMC cancer · 2026Article
- Tongue cancer in pregnancy: challenges and outcomes. A case series and review of the literature.Oral and maxillofacial surgery · 2025Review
- Lip, Oral Cavity, and Pharyngeal Cancers: Global Epidemiology, Risk Factors, and Prevention: A Narrative Review.Health science reports · 2025Article
- Analysis of preferences and responses to recall in adolescent and young adult head and neck cancer survivors treated with radiotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Investigation of CBX4 Polymorphisms and Their Association with Clinicopathological Features in Asian Patients with Oral Squamous Cell Carcinoma.Journal of Cancer · 2025Article
- Paclitaxel for second-line treatment of squamous cell carcinoma of the head and neck: A multicenter retrospective Italian study.World journal of clinical oncology · 2024Article
- Clinicopathological Characteristics, Prognostic Factors, and Treatment Outcomes of Patients with Oral Tongue Squamous Cell Carcinoma Treated with Glossectomy: A Tertiary Oncology Center Experience.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Leukoplakia and erythroplakia in youngers versus older individuals: a clinicopathological retrospective study.Medicina oral, patologia oral y cirugia bucal · 2024Article
- Trends in Oral Tongue Cancer Incidence in the US.JAMA otolaryngology-- head & neck surgery · 2024Article
- Lymphocyte-to-Monocyte Ratio Might Serve as a Prognostic Marker in Young Patients with Tongue Squamous Cell Carcinoma.Journal of personalized medicine · 2024Article
- Poor oral health influences head and neck cancer patient survival: an International Head and Neck Cancer Epidemiology Consortium pooled analysis.Journal of the National Cancer Institute · 2024Article
- Oral cancer in young adults: should we approach these patients differently?Frontiers in oncology · 2024Article
- Analysis of MUC6 polymorphisms on the clinicopathologic characteristics of Asian patients with oral squamous cell carcinoma.Journal of cellular and molecular medicine · 2023Article
- AberrantBiomedicines · 2023Article
- Oral Cavity Squamous Cell Carcinoma Risk Factors: State of the Art.Journal of clinical medicine · 2023Review
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
63 authors at 6 institutions in 3 countries.
Tatiana Natasha ToporcovFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Ariana ZnaorFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Zuo-Feng ZhangFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Guo-Pei YuFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Deborah M WinnFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Qingyi WeiFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Marta VilenskyFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Thomas VaughanFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Peter ThomsonFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Renato TalaminiFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Neonila Szeszenia-DabrowskaFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Erich M SturgisFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Elaine SmithFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Oxana ShanginaFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Stephen M SchwartzFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Stimson SchantzFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Peter RudnaiFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Lorenzo RichiardiFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Heribert RamrothFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Mark P PurdueFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Andrew F OlshanFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
José Eluf-NetoFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Joshua MuscatFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Raquel Ajub MoysesFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Hal MorgensternFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Ana MenezesFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Michael McCleanFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Keitaro MatsuoFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Dana MatesFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Tatiana V MacfarlaneFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Jolanta LissowskaFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Fabio LeviFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Philip LazarusFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Carlo La VecchiaFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Pagona LagiouFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Sergio KoifmanFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Kristina KjaerheimFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Karl KelseyFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Ivana HolcatovaFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Rolando HerreroFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Claire HealyFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Richard B HayesFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Silvia FranceschiFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Leticia FernandezFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Eleonora FabianovaFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Alexander W DaudtFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Otávio Alberto CurioniFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Luigino Dal MasoFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Maria Paula CuradoFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
David I ConwayFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Chu ChenFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Xavier CastellsagueFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Cristina CanovaFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Gabriella CadoniFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Paul BrennanFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Stefania BocciaFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
José Leopoldo Ferreira AntunesFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Wolfgang AhrensFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Antonio AgudoFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Paolo BoffettaFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Mia HashibeFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Yuan-Chin Amy LeeFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Victor Wünsch FilhoFaculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil, Croatian National Cancer Registry, Zagreb, Croatia, UCLA School of Public Health, Los Angeles, CA, USA, Medical Informatics Center, Peking University, Beijing, China, and New York Medical College, Valhalla, NY, USA, National Cancer Institute, Bethesda, MD, USA, UT-MD Anderson Cancer Center, Houston, TX, USA, Institute of Oncology Angel H. Roffo, University of Buenos Aires, Buenos Aires, Argentina, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, School of Dental Sciences, University of Newcastle, Newcastle, UK, Aviano Cancer Centre, Aviano, Italy, Institute of Occupational Medicine, Lodz, Poland, College of Public Health, University of Iowa, Iowa City, IA, USA, Cancer Research Centre, Moscow, Russia, Fred Hutchinson Cancer Research Center, Seattle, WA, USA, New York Eye and Ear Infirmary, New York, NY, USA, National Institute of Environmental Health, Budapest, Hungary, Department of Medical Science, Cancer Epidemiology Unit, University of Turin, Turin, Italy, Institute of Public Health, University of Heidelberg, Heidelberg, Germany, University of North Carolina School of Public Health, Chapel Hill, NC, USA, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Penn State College of Medicine, Hershey, PA, USA, Cirurgia de Cabeça e Pescoço (LIM 28), Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Departments of Epidemiology and Environmental Health Sciences, School of Public Health, and Comprehensive Cancer Center, University of Michigan Ann Arbor, Ann Arbor, MI, USA, Universidade Federal de Pelotas, Pelotas, Brazil, Boston University School of Public Health, Boston, MA, USA, Aichi Cancer Center Research Institute, Nagoya, Japan, Institute of Public Health, Bucharest, Romania, University of Aberdeen Dental School, Aberdeen, UK, The M Skasodowska-Curie Memorial Cancer Center and Institute of Oncology, Department of Cancer Epidemiology and Pre
Huntsman Cancer Institute · USHeidelberg University · DEInstitut Català d'Oncologia · ESIcahn School of Medicine at Mount Sinai · USNational Cancer Institute · USUniversity of Utah · US
Funding
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3MUCLA SPORE IN LUNG CANCERP50CA090388 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2001 to 2008
$13.0MUDP GLUCURONOSYLTRANSFERASES, DETOXIFICATION OF NNKP01CA068384 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI LAZARUS, PHILIP · 1995 to 2005
$8.5MUCLA CANCER EPIDEMIOLOGY TRAINING PROGRAMT32CA009142 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHANG, ZUO-FENG · 1986 to 2024
$6.3MMolecular Epidemiology of Head and Neck CancerR01ES011740 · NIEHS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WEI, QINGYI · 2001 to 2012
$6.3MLUNG CANCER CHEMOPREVENTION WITH CELECOXIB IN EX-SMOKERSU01CA096134 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAO, JENNY T · 2002 to 2007
$5.1MUDPGLUCURONOSYLTRANSFERASE GENOTYPE AND ORAL CANCER RISKR01DE013158 · NIDCR · UNIVERSITY OF SOUTH FLORIDA · PI LAZARUS, PHILIP · 2000 to 2011
$3.6MSeroepidemiologic Study of HPV and Oral CancerR01DE013110 · NIDCR · UNIVERSITY OF IOWA · PI SMITH, ELAINE M. · 1999 to 2003
$2.5MMARIJUANA USE AND THE RISKS OF LUNG AND OTHER CANCERSR01DA011386 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MORGENSTERN, HAL M · 1999 to 2003
$1.8MGenetic Predictors for DNA Repair Phenotype in CMMR01CA100264 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WEI, QINGYI · 2004 to 2008
$1.5MEpidemiology of protein glutathiolationK07CA104231 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI MUSCAT, JOSHUA E · 2005 to 2009
$681kMolecular Epidemiology and Gene-Environment InteractionR21ES011667 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHANG, ZUO-FENG · 2002 to 2004
$651kFIC NIH HHS FIRCA TW01500NCI NIH HHS K07CA104231NCI NIH HHS P01CA068384NCI NIH HHS P50CA90388NCI NIH HHS R01CA048996NCI NIH HHS R01CA100264NCI NIH HHS R01CA30022NCI NIH HHS R01CA51845NCI NIH HHS R01CA61188NCI NIH HHS R03CA113157NCI NIH HHS R03CA77954NCI NIH HHS T32 CA009142NCI NIH HHS T32CA09142NCI NIH HHS U01CA96134NIDA NIH HHS R01DA11386NIDCR NIH HHS R01DE012609NIDCR NIH HHS R01DE11979NIDCR NIH HHS R01DE13110NIDCR NIH HHS R01DE13158NIDCR NIH HHS R03DE016611NIEHS NIH HHS P30 ES010126NIEHS NIH HHS P30ES010126NIEHS NIH HHS R01ES11740NIEHS NIH HHS R21ES011667World Health Organization 001
Abstract
backgroundIncreasing incidence of head and neck cancer (HNC) in young adults has been reported. We aimed to compare the role of major risk factors and family history of cancer in HNC in young adults and older patients.
methodsWe pooled data from 25 case-control studies and conducted separate analyses for adults ≤ 45 years old ('young adults', 2010 cases and 4042 controls) and >45 years old ('older adults', 17700 cases and 22 704 controls). Using logistic regression with studies treated as random effects, we estimated adjusted odds ratios (ORs) and 95% confidence intervals (CIs).
resultsThe young group of cases had a higher proportion of oral tongue cancer (16.0% in women; 11.0% in men) and unspecified oral cavity / oropharynx cancer (16.2%; 11.1%) and a lower proportion of larynx cancer (12.1%; 16.6%) than older adult cases. The proportions of never smokers or never drinkers among female cases were higher than among male cases in both age groups. Positive associations with HNC and duration or pack-years of smoking and drinking were similar across age groups. However, the attributable fractions (AFs) for smoking and drinking were lower in young when compared with older adults (AFs for smoking in young women, older women, young men and older men, respectively, = 19.9% (95% CI=9.8%, 27.9%), 48.9% (46.6%, 50.8%), 46.2% (38.5%, 52.5%), 64.3% (62.2%, 66.4%); AFs for drinking=5.3% (-11.2%, 18.0%), 20.0% (14.5%, 25.0%), 21.5% (5.0%, 34.9%) and 50.4% (46.1%, 54.3%). A family history of early-onset cancer was associated with HNC risk in the young [OR=2.27 (95% CI=1.26, 4.10)], but not in the older adults [OR=1.10 (0.91, 1.31)]. The attributable fraction for family history of early-onset cancer was 23.2% (8.60% to 31.4%) in young compared with 2.20% (-2.41%, 5.80%) in older adults.
conclusionsDifferences in HNC aetiology according to age group may exist. The lower AF of cigarette smoking and alcohol drinking in young adults may be due to the reduced length of exposure due to the lower age. Other characteristics, such as those that are inherited, may play a more important role in HNC in young adults compared with older adults.
Indexed as
AdultAge FactorsAlcohol DrinkingCase-Control StudiesFemaleGenetic Predisposition to DiseaseHead and Neck NeoplasmsHumansIncidenceMaleMiddle AgedOdds RatioRegistriesRisk FactorsSex FactorsSmokingadultalcohol drinkingdietHead and neck neoplasmssmoking
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