Evidence map›Paper›PMID 25613307›Full record

Trial reportStroke2015

Effect of patching on reducing restenosis in the carotid revascularization endarterectomy versus stenting trial.

Mahmoud Malas, Natalia O Glebova, Susan E Hughes, Jenifer H Voeks, Umair Qazi, Wesley S Moore, Brajesh K Lal, George Howard, Rafael Llinas, Thomas G Brott

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Stroke, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00004732 (Carotid Revascularization Endarterectomy Versus Stenting Trial), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00004732 nacompletednot on this map

Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST)

TypeinterventionalSponsorRutgers, The State University of New JerseyRan2000 to 2016Enrolled2,502ConditionsAtherosclerosis, Stroke, Carotid Stenosis, Cerebral InfarctionArmsCarotid Endarterectomy (CEA), Carotid Artery Stenting (CAS)
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 63 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Annals of translational medicine · 2021
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Outcomes of Carotid Endarterectomy with Primary Closure.The International journal of angiology : official publication of the International College of Angiology, Inc · 2017
    Article
  12. Review
  13. Comparative Review of the Treatment Methodologies of Carotid Stenosis.The International journal of angiology : official publication of the International College of Angiology, Inc · 2015
    Review
  14. Carotid Endarterectomy: Current Concepts and Practice Patterns.The International journal of angiology : official publication of the International College of Angiology, Inc · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Mahmoud MalasFrom the Department of Vascular and Endovascular Surgery, Johns Hopkins University, Baltimore, MD (M.M., U.Q., R.L.); Department of Surgery, University of Colorado Denver, Aurora (N.O.G.); Department of Surgery, New Jersey Medical School, Rutgers University, Newark (S.E.H.); Department of Neurology, Medical University of South Carolina, Charleston (J.H.V.); Department of Surgery, University of California Los Angeles Medical Center (W.S.M.); Department of Surgery, University of Maryland Medical Center, Baltimore (B.K.L.); Department of Biostatistics, University of Alabama at Birmingham (G.H.); and Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.).
Natalia O GlebovaFrom the Department of Vascular and Endovascular Surgery, Johns Hopkins University, Baltimore, MD (M.M., U.Q., R.L.); Department of Surgery, University of Colorado Denver, Aurora (N.O.G.); Department of Surgery, New Jersey Medical School, Rutgers University, Newark (S.E.H.); Department of Neurology, Medical University of South Carolina, Charleston (J.H.V.); Department of Surgery, University of California Los Angeles Medical Center (W.S.M.); Department of Surgery, University of Maryland Medical Center, Baltimore (B.K.L.); Department of Biostatistics, University of Alabama at Birmingham (G.H.); and Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.).
Susan E HughesFrom the Department of Vascular and Endovascular Surgery, Johns Hopkins University, Baltimore, MD (M.M., U.Q., R.L.); Department of Surgery, University of Colorado Denver, Aurora (N.O.G.); Department of Surgery, New Jersey Medical School, Rutgers University, Newark (S.E.H.); Department of Neurology, Medical University of South Carolina, Charleston (J.H.V.); Department of Surgery, University of California Los Angeles Medical Center (W.S.M.); Department of Surgery, University of Maryland Medical Center, Baltimore (B.K.L.); Department of Biostatistics, University of Alabama at Birmingham (G.H.); and Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.).
Jenifer H VoeksFrom the Department of Vascular and Endovascular Surgery, Johns Hopkins University, Baltimore, MD (M.M., U.Q., R.L.); Department of Surgery, University of Colorado Denver, Aurora (N.O.G.); Department of Surgery, New Jersey Medical School, Rutgers University, Newark (S.E.H.); Department of Neurology, Medical University of South Carolina, Charleston (J.H.V.); Department of Surgery, University of California Los Angeles Medical Center (W.S.M.); Department of Surgery, University of Maryland Medical Center, Baltimore (B.K.L.); Department of Biostatistics, University of Alabama at Birmingham (G.H.); and Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.).
Umair QaziFrom the Department of Vascular and Endovascular Surgery, Johns Hopkins University, Baltimore, MD (M.M., U.Q., R.L.); Department of Surgery, University of Colorado Denver, Aurora (N.O.G.); Department of Surgery, New Jersey Medical School, Rutgers University, Newark (S.E.H.); Department of Neurology, Medical University of South Carolina, Charleston (J.H.V.); Department of Surgery, University of California Los Angeles Medical Center (W.S.M.); Department of Surgery, University of Maryland Medical Center, Baltimore (B.K.L.); Department of Biostatistics, University of Alabama at Birmingham (G.H.); and Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.).
Wesley S MooreFrom the Department of Vascular and Endovascular Surgery, Johns Hopkins University, Baltimore, MD (M.M., U.Q., R.L.); Department of Surgery, University of Colorado Denver, Aurora (N.O.G.); Department of Surgery, New Jersey Medical School, Rutgers University, Newark (S.E.H.); Department of Neurology, Medical University of South Carolina, Charleston (J.H.V.); Department of Surgery, University of California Los Angeles Medical Center (W.S.M.); Department of Surgery, University of Maryland Medical Center, Baltimore (B.K.L.); Department of Biostatistics, University of Alabama at Birmingham (G.H.); and Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.).
Brajesh K LalFrom the Department of Vascular and Endovascular Surgery, Johns Hopkins University, Baltimore, MD (M.M., U.Q., R.L.); Department of Surgery, University of Colorado Denver, Aurora (N.O.G.); Department of Surgery, New Jersey Medical School, Rutgers University, Newark (S.E.H.); Department of Neurology, Medical University of South Carolina, Charleston (J.H.V.); Department of Surgery, University of California Los Angeles Medical Center (W.S.M.); Department of Surgery, University of Maryland Medical Center, Baltimore (B.K.L.); Department of Biostatistics, University of Alabama at Birmingham (G.H.); and Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.).
George HowardFrom the Department of Vascular and Endovascular Surgery, Johns Hopkins University, Baltimore, MD (M.M., U.Q., R.L.); Department of Surgery, University of Colorado Denver, Aurora (N.O.G.); Department of Surgery, New Jersey Medical School, Rutgers University, Newark (S.E.H.); Department of Neurology, Medical University of South Carolina, Charleston (J.H.V.); Department of Surgery, University of California Los Angeles Medical Center (W.S.M.); Department of Surgery, University of Maryland Medical Center, Baltimore (B.K.L.); Department of Biostatistics, University of Alabama at Birmingham (G.H.); and Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.).
Rafael LlinasFrom the Department of Vascular and Endovascular Surgery, Johns Hopkins University, Baltimore, MD (M.M., U.Q., R.L.); Department of Surgery, University of Colorado Denver, Aurora (N.O.G.); Department of Surgery, New Jersey Medical School, Rutgers University, Newark (S.E.H.); Department of Neurology, Medical University of South Carolina, Charleston (J.H.V.); Department of Surgery, University of California Los Angeles Medical Center (W.S.M.); Department of Surgery, University of Maryland Medical Center, Baltimore (B.K.L.); Department of Biostatistics, University of Alabama at Birmingham (G.H.); and Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.).
Thomas G BrottFrom the Department of Vascular and Endovascular Surgery, Johns Hopkins University, Baltimore, MD (M.M., U.Q., R.L.); Department of Surgery, University of Colorado Denver, Aurora (N.O.G.); Department of Surgery, New Jersey Medical School, Rutgers University, Newark (S.E.H.); Department of Neurology, Medical University of South Carolina, Charleston (J.H.V.); Department of Surgery, University of California Los Angeles Medical Center (W.S.M.); Department of Surgery, University of Maryland Medical Center, Baltimore (B.K.L.); Department of Biostatistics, University of Alabama at Birmingham (G.H.); and Department of Neurology, Mayo Clinic, Jacksonville, FL (T.G.B.). brott.thomas@mayo.edu.
Medical University of South Carolina · USRutgers, The State University of New Jersey · USUniversity of California, Los Angeles · USUniversity of Colorado Denver · USLos Angeles Medical Center · USUniversity of Maryland Medical Center · US

Funding

Carotid Revascularization Endarterectomy vs Stenting TrialR01NS038384 · NINDS · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI BROTT, THOMAS G · 1999 to 2010
$40.7M
Carotid Revascularization Endarterectomy vs. Stenting Trial: Long Term Follow-upU01NS038384 · NINDS · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI BROTT, THOMAS G, SHEFFET, ALICE J · 2011 to 2016
$15.4M
NINDS NIH HHS R01 NS038384NINDS NIH HHS U01 NS038384NINDS NIH HHS U01NS038384
6 · The paper itself

Abstract

background and purposeThe purpose is to determine whether patching during carotid endarterectomy (CEA) affects the perioperative and long-term risks of restenosis, stroke, death, and myocardial infarction as compared with primary closure.

methodsWe identified all patients who were randomized and underwent CEA in Carotid Revascularization Endarterectomy versus Stenting Trial. CEA patients who received a patch were compared with patients who underwent CEA with primary closure without a patch. We compared periprocedural and 4-year event rates, 2-year restenosis rates, and rates of reoperation between the 2 groups. We further analyzed results by surgeon specialty.

resultsThere were 1151 patients who underwent CEA (753 [65%] with patch and 329 [29%] with primary closure). We excluded 44 patients who underwent eversion CEA and 25 patients missing CEA data (5%). Patch use differed by surgeon specialty: 89% of vascular surgeons, 6% of neurosurgeons, and 76% of thoracic surgeons patched. Comparing patients who received a patch versus those who did not, there was a significant reduction in the 2-year risk of restenosis, and this persisted after adjustment by surgeon specialty (hazard ratio, 0.35; 95% confidence interval, 0.16-0.74; P=0.006). There were no significant differences in the rates of periprocedural stroke and death (hazard ratio, 1.58; 95% confidence interval, 0.33-7.58; P=0.57), in immediate reoperation (hazard ratio, 0.6; 95% confidence interval, 0.16-2.27; P=0.45), or in the 4-year risk of ipsilateral stroke (hazard ratio, 1.23; 95% confidence interval, 0.42-3.63; P=0.71).

conclusionsPatch closure in CEA is associated with reduction in restenosis although it is not associated with improved clinical outcomes. Thus, more widespread use of patching should be considered to improve long-term durability. CLINICAL TRIAL REGISTRATION URL: http://www.clinicaltrials.gov. Unique identifier: NCT00004732.

Indexed as

AgedCarotid ArteriesCarotid StenosisEndarterectomy, CarotidFemaleHeart Valve DiseasesHumansMaleMiddle AgedMyocardial InfarctionProportional Hazards ModelsProspective StudiesRiskStentsStrokeTreatment Outcomecarotid artery narrowingcarotid artery stenosiscarotid endarterectomyvascular closure patches

Identifiers

PMID25613307
PMCPMC4586019
OpenAlexW2127089415

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.