Evidence map›Paper›PMID 25613059›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2015

Supramolecular nanosubstrate-mediated delivery for reprogramming and transdifferentiation of mammalian cells.

Shuang Hou, Jin-sil Choi, Kuan-Ju Chen, Yang Zhang, Jinliang Peng, Mitch A Garcia, Jue-Hua Yu, Kaushali Thakore-Shah, Tracy Ro, Jie-Fu Chen and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Shuang HouNational Center for Nanoscience and Technology, Beijing, 100190, China.
Jin-sil ChoiDepartment of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, 90095-1770, USA.
Kuan-Ju ChenDepartment of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, 90095-1770, USA.
Yang ZhangDepartment of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, 90095-1770, USA.
Jinliang PengDepartment of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, 90095-1770, USA.
Mitch A GarciaDepartment of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, 90095-1770, USA.
Jue-Hua YuDepartment of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095-7088.
Kaushali Thakore-ShahMolecular Biology Institute, Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, CA, 90024, USA.
Tracy RoDepartment of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, 90095-1770, USA.
Jie-Fu ChenDepartment of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, 90095-1770, USA.
Parham PeydaDepartment of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, 90095-1770, USA.
Guoping FanDepartment of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095-7088.
April D PyleMolecular Biology Institute, Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, CA, 90024, USA.
Hao WangNational Center for Nanoscience and Technology, Beijing, 100190, China.
Hsian-Rong TsengDepartment of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging (CIMI), California NanoSystems Institute (CNSI), University of California, Los Angeles, CA, 90095-1770, USA.

Funding

Reprogramming and Directed Differentiation of Skeletal Muscle Cells from hPSCs.R01AR064327 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI April D Pyle · 2013 to 2026
$6.4M
UCLA Muscular Dystrophy Core CenterP30AR057230 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SPENCER, MELISSA JAN · 2009 to 2018
$6.2M
Generation of hPSCs Using Reprogramming Proteins-Encapsulated NanoparticlesR21GM098982 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TSENG, HSIAN-RONG · 2011 to 2012
$410k
Supramolecular Nanoparticle-Based PET Probes for Pretargeted Tumor ImagingR21EB016270 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TSENG, HSIAN-RONG · 2013 to 2014
$400k
NIAMS NIH HHS P30 AR057230NIAMS NIH HHS R01 AR064327NIAMS NIH HHS R01AR064327NIBIB NIH HHS R21 EB016270NIBIB NIH HHS R21EB016270NIGMS NIH HHS R21 GM098982NIGMS NIH HHS R21GM098982
6 · The paper itself

Abstract

Supramolecular nanosubstrate-mediated delivery (SNSMD) leverages the power of molecular self-assembly and a nanostructured substrate platform for the low toxicity, highly efficient co-delivery of biological factors encapsulated in a nanovector. Human fibroblasts are successfully reprogrammed into induced pluripotent stems and transdifferentiated into induced neuronal-like cells.

Indexed as

Cell TransdifferentiationCellular ReprogrammingCell LineCellular Reprogramming TechniquesFibroblastsGenetic VectorsGene Transfer TechniquesHumansNanocapsulesNanotechnologyPolymorphism, Single NucleotideNanocapsulescell reprogrammingcell transdifferentiationnanoparticlesnanosubstrates, gene deliverysupramolecular chemistry

Identifiers

PMID25613059
PMCPMC4961214

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.