ArticleThe international journal of neuropsychopharmacology2014
Adolescent intermittent ethanol exposure is associated with increased risky choice and decreased dopaminergic and cholinergic neuron markers in adult rats.
Article in The international journal of neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
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Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Adolescent Alcohol and Stress Exposure Rewires Key Cortical Neurocircuitry.Frontiers in neuroscience · 2022Pooled it
- Developmental alcohol exposure: Impacts on medial prefrontal cortex morphology and the excitatory-inhibitory balance.Progress in neuro-psychopharmacology & biological psychiatry · 2026Review
- Adolescent alcohol exposure disrupts episodic-like memory by impairing dopamine synapses in the mouse prelimbic cortex.Neuropharmacology · 2025Article
- Prelimbic cortex perineuronal net expression and social behavior: Impact of adolescent intermittent ethanol exposure.Neuropharmacology · 2025Article
- Cross-species translational paradigms for assessing positive valence system as defined by the RDoC matrix.Journal of neurochemistry · 2025Review
- Voluntary alcohol consumption during distinct phases of adolescence differentially alters adult fear acquisition, extinction and renewal in male and female rats.Stress (Amsterdam, Netherlands) · 2023Article
- Voluntary alcohol consumption during distinct phases of adolescence differentially alters adult fear acquisition, extinction and renewal in male and female rats.bioRxiv : the preprint server for biology · 2023Article
- Sex-specific decision-making impairments and striatal dopaminergic changes after binge drinking history in rats.Frontiers in pharmacology · 2023Article
- Impact of adolescent intermittent ethanol exposure on interneurons and their surrounding perineuronal nets in adulthood.Alcoholism, clinical and experimental research · 2022Article
- Sex-specific effects of adolescent intermittent ethanol exposure-induced dysregulation of hippocampal glial cells in adulthood.Alcohol (Fayetteville, N.Y.) · 2022Article
- Adolescent brain maturation and the neuropathological effects of binge drinking: A critical review.Frontiers in neuroscience · 2022Review
- The association between risky decision making and cocaine conditioned place preference is moderated by sex.Drug and alcohol dependence · 2021Article
- Primed for addiction: A critical review of the role of microglia in the neurodevelopmental consequences of adolescent alcohol drinking.Alcoholism, clinical and experimental research · 2021Review
- Adolescent Ethanol Exposure Alters Cholinergic Function and Apical Dendritic Branching Within the Orbital Frontal Cortex.Neuroscience · 2021Article
- Advances in understanding meso-cortico-limbic-striatal systems mediating risky reward seeking.Journal of neurochemistry · 2021Review
- The role of sex in the persistent effects of adolescent alcohol exposure on behavior and neurobiology in rodents.International review of neurobiology · 2021Review
- Nerve Growth Factor in Alcohol Use Disorders.Current neuropharmacology · 2021Review
- Review of Orbitofrontal Cortex in Alcohol Dependence: A Disrupted Cognitive Map?Alcoholism, clinical and experimental research · 2020Review
- Does Alcohol Initiation in Early-To-Middle Adolescence Predict Changes in Reward Motivation? Evidence of Sex Differences.Alcoholism, clinical and experimental research · 2020Article
- Gamma oryzanol impairs alcohol-induced anxiety-like behavior in mice via upregulation of central monoamines associated with Bdnf and Il-1β signaling.Scientific reports · 2020Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundBinge drinking is prevalent during adolescence and may have effects on the adult brain and behavior. The present study investigated whether adolescent intermittent ethanol exposure alters adult risky choice and prefrontal dopaminergic and forebrain cholinergic neuronal marker levels in male Wistar rats.
methodsAdolescent (postnatal day 28-53) rats were administered 5 g/kg of 25% (vol/vol) ethanol 3 times/d in a 2-days-on/2-days-off exposure pattern. In adulthood, risky choice was assessed in the probability discounting task with descending and ascending series of large reward probabilities and after acute ethanol challenge. Immunohistochemical analyses assessed tyrosine hydroxylase, a marker of dopamine and norepinephrine in the prelimbic and infralimbic cortices, and choline acetyltransferase, a marker of cholinergic neurons, in the basal forebrain.
resultsAll of the rats preferred the large reward when it was delivered with high probability. When the large reward became unlikely, control rats preferred the smaller, safe reward, whereas adolescent intermittent ethanol-exposed rats continued to prefer the risky alternative. Acute ethanol had no effect on risky choice in either group of rats. Tyrosine hydroxylase (prelimbic cortex only) and choline acetyltransferase immunoreactivity levels were decreased in adolescent intermittent ethanol-exposed rats compared with controls. Risky choice was negatively correlated with choline acetyltransferase, implicating decreased forebrain cholinergic activity in risky choice.
conclusionsThe decreases in tyrosine hydroxylase and choline acetyltransferase immunoreactivity suggest that adolescent intermittent ethanol exposure has enduring neural effects that may lead to altered adult behaviors, such as increased risky decision making. In humans, increased risky decision making could lead to maladaptive, potentially harmful consequences.
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