ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2015
Liver preservation with machine perfusion and a newly developed cell-free oxygen carrier solution under subnormothermic conditions.
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
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Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 128 citations in OpenAlex.
- Optimizing Livers for Transplantation Using Machine Perfusion versus Cold Storage in Large Animal Studies and Human Studies: A Systematic Review and Meta-Analysis.BioMed research international · 2018Pooled it
- An evaluation of the safety and preliminary efficacy of peri- and post-operative treprostinil in preventing ischemia and reperfusion injury in adult orthotopic liver transplant recipients.Clinical transplantation · 2021Trial
- Mild hypothermia attenuates hepatic ischemia-reperfusion injury by regulating FoxO1/PPARα pathway.Scientific reports · 2025Article
- Beyond the icebox: modern strategies in organ preservation for transplantation.Clinical transplantation and research · 2024Review
- Controlled oxygen delivery to power tissue regeneration.Nature communications · 2024Review
- Gradual rewarming with a hemoglobin-based oxygen carrier improves viability of donation after circulatory death in rat livers.Frontiers in transplantation · 2024Article
- The artificial oxygen carrier erythrocruorin-characteristics and potential significance in medicine.Journal of molecular medicine (Berlin, Germany) · 2023Review
- Article
- Current practice and novel approaches in organ preservation.Frontiers in transplantation · 2023Review
- Hemoglobin-based oxygen carriers: Clinical application of HBOC-201 as an alternative to red blood cells for machine perfusion in liver transplantation.Surgery in practice and science · 2022Review
- Cold but not too cold: advances in hypothermic and normothermic organ perfusion.Korean journal of transplantation · 2022Review
- Optimization of Ex Vivo Machine Perfusion and Transplantation of Vascularized Composite Allografts.The Journal of surgical research · 2022Article
- Application of polymerized porcine hemoglobin in theFrontiers in bioengineering and biotechnology · 2022Article
- Blood substitutes: Basic science, translational studies and clinical trials.Frontiers in medical technology · 2022Article
- Two Compartment Evaluation of Liver Grafts During Acellular Room Temperature Machine Perfusion (acRTMP) in a Rat Liver Transplant Model.Frontiers in medicine · 2022Article
- Article
- Mitochondrial Targeting Therapy Role in Liver Transplant Preservation Lines: Mechanism and Therapeutic Strategies.Cureus · 2021Review
- Subnormothermic Ex Vivo Lung Perfusion Temperature Improves Graft Preservation in Lung Transplantation.Cells · 2021Article
- Hemoglobin-Based Oxygen Carriers: Potential Applications in Solid Organ Preservation.Frontiers in pharmacology · 2021Review
- New Applications of HBOC-201: A 25-Year Review of the Literature.Frontiers in medicine · 2021Review
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 1 country.
Funding
Abstract
We describe a new preservation modality combining machine perfusion (MP) at subnormothermic conditions(21 °C) with a new hemoglobin-based oxygen carrier (HBOC) solution. MP (n=6) was compared to cold static preservation (CSP; n=6) in porcine orthotopic liver transplants after 9 h of cold ischemia and 5-day follow-up. Recipients' peripheral blood, serial liver biopsies, preservation solutions and bile specimens were collected before, during and after liver preservation. Clinical laboratorial and histological analyses were performed in addition to mitochondrial functional assays, transcriptomic, metabolomic and inflammatory inflammatory mediator analyses. Compared with CSP, MP animals had: (1) significantly higher survival (100%vs. 33%; p<0.05); (2) superior graft function (p<0.05);(3) eight times higher hepatic O2 delivery than O2 consumption (0.78 mL O2/g/h vs. 0.096 mL O2/g/h) during MP; and (4) significantly greater bile production (MP=378.5 ± 179.7; CS=151.6 ± 116.85). MP downregulated interferon (IFN)-α and IFN-γ in liver tissue. MP allografts cleared lactate, produced urea, sustained gluconeogenesis and produced hydrophilic bile after reperfusion. Enhanced oxygenation under subnormothermic conditions triggers regenerative and cell protective responses resulting in improved allograft function. MP at 21 °C with the HBOC solution significantly improves liver preservation compared to CSP.
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Registered trials
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