ArticlePLoS neglected tropical diseases2015
The influence of HIV and schistosomiasis on renal function: a cross-sectional study among children at a hospital in Tanzania.
Article in PLoS neglected tropical diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Ligand based-design of potential schistosomiasis inhibitors through QSAR, homology modeling, molecular dynamics, pharmacokinetics, and DFT studies.Journal of Taibah University Medical Sciences · 2024Article
- Burden and severity of deranged electrolytes and kidney function in children seen in a tertiary hospital in Kano, northern Nigeria.PloS one · 2023Article
- Sustained high blood pressure and 24-h ambulatory blood pressure monitoring in Tanzanian adolescents.Scientific reports · 2021Article
- Diabetic Microvascular Complications Among Children and Adolescents in Northwestern Tanzania: A Cross-Sectional Study.Annals of global health · 2020Article
- Renal abnormalities and its associated factors among school-aged children living inTropical medicine and health · 2020Article
- Developing nephrology services in low income countries: a case of Tanzania.BMC nephrology · 2019Article
- The ethical imperative to treat NCDs during research in Africa.The Lancet. Global health · 2019Article
- Prevalence and factors associated with renal dysfunction in children admitted to two hospitals in northwestern Tanzania.BMC nephrology · 2019Article
- Article
- Proteinuric kidney disease in children at Queen Elizabeth Central Hospital, Malawi.BMC nephrology · 2018Article
- Article
- Tropical Parasitic Infections in Individuals Infected with HIV.Current tropical medicine reports · 2017Article
- Prevalence of chronic kidney disease in diabetic adult out-patients in Tanzania.BMC nephrology · 2016Article
- Decreased renal function and associated factors in cities, towns and rural areas of Tanzania: a community-based population survey.Tropical medicine & international health : TM & IH · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundSchistosomiasis and HIV are both associated with kidney disease. Prevalence and factors associated with abnormal renal function among HIV-infected children in Africa compared to uninfected controls have not been well described in a schistosomiasis endemic area. METHODOLOGY/PRINCIPAL
findingsThis cross-sectional study was conducted at the Sekou Toure Regional Hospital HIV clinic in Mwanza, Tanzania. A total of 122 HIV-infected children and 122 HIV-uninfected siblings were consecutively enrolled. Fresh urine was obtained for measurement of albuminuria and Schistosoma circulating cathodic antigen. Blood was collected for measurement of serum creatinine. Estimated glomerular filtration rate (eGFR) was calculated using the modified Schwartz equation. Renal dysfunction was defined operationally as eGFR<60 mL/min/1.73 m2 and/or albuminuria>20 mg/L in a single sample. Among 122 HIV-infected children, 61/122 (50.0%) met our criteria for renal dysfunction: 54/122 (44.3%) had albuminuria>20 mg/L and 9/122 (7.4%) had eGFR<60. Among 122 HIV-uninfected children, 51/122 (41.8%) met our criteria for renal dysfunction: 48/122 (39.3%) had albuminuria>20 mg/L and 6/122 (4.9%) had eGFR<60. Schistosomiasis was the only factor significantly associated with renal dysfunction by multivariable logistic regression (OR = 2.51, 95% CI 1.46-4.31, p = 0.001). CONCLUSIONS/SIGNIFICANCE: A high prevalence of renal dysfunction exists among both HIV-infected Tanzanian children and their HIV-uninfected siblings. Schistosomiasis was strongly associated with renal dysfunction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.