Evidence map›Paper›PMID 25612302›Full record

ArticleThe Journal of comparative neurology2015

Differential expression of protocadherin-19, protocadherin-17, and cadherin-6 in adult zebrafish brain.

Qin Liu, Sunil Bhattarai, Nan Wang, Alicja Sochacka-Marlowe

Abstract read
In one paragraph

Article in The Journal of comparative neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Mapping of Morphine-InducedFrontiers in neuroanatomy · 2020
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Qin LiuDepartment of Biology and Integrated Bioscience Program, University of Akron, Akron, Ohio, 44325.
Sunil Bhattarai
Nan Wang
Alicja Sochacka-Marlowe
University of Akron · US

Funding

Protocadherin-17 and -9 Function in Retinal DevelopmentR15EY013879 · NEI · UNIVERSITY OF AKRON · PI LIU, QIN · 2001 to 2011
$959k
NEI NIH HHS EY13879NEI NIH HHS R15 EY013879
6 · The paper itself

Abstract

Cell adhesion molecule cadherins play important roles in both development and maintenance of adult structures. Most studies on cadherin expression have been carried out in developing organisms, but information on cadherin distribution in adult vertebrate brains is limited. In this study we used in situ hybridization to examine mRNA expression of three cadherins, protocadherin-19, protocadherin-17, and cadherin-6 in adult zebrafish brain. Each cadherin exhibits a distinct expression pattern in the fish brain, with protocadherin-19 and protocadherin-17 showing much wider and stronger expression than that of cadherin-6. Both protocadherin-19 and protocadherin-17-expressing cells occur throughout the brain, with strong expression in the ventromedial telencephalon, periventricular regions of the thalamus and anterior hypothalamus, stratum periventriculare of the optic tectum, dorsal tegmental nucleus, granular regions of the cerebellar body and valvula, and superficial layers of the facial and vagal lobes. Numerous sensory structures (e.g., auditory, gustatory, lateral line, olfactory, and visual nuclei) and motor nuclei (e.g., oculomotor, trochlear, trigeminal motor, abducens, and vagal motor nuclei) contain protocadherin-19 and/or protocadherin-17-expressing cell. Expression of these two protocadherins is similar in the ventromedial telencephalon, thalamus, hypothalamus, facial, and vagal lobes, but substantially different in the dorsolateral telencephalon, intermediate layers of the optic tectum, and cerebellar valvula. In contrast to the two protocadherins, cadherin-6 expression is much weaker and limited in the adult fish brain.

Indexed as

AnimalsBrainCadherinsFemaleIn Situ HybridizationMaleProtocadherinsRNA, MessengerSpecies SpecificitySpinal CordZebrafishZebrafish ProteinsCadherinspcdh17 protein, Danio rerioPcdh19 protein, zebrafishProtocadherinsRNA, MessengerZebrafish Proteinscell adhesion moleculescerebellummotor nucleiRRID: 2DB-GENO-030619-2RRID: AB_193290RRID: AB_514497, Roche Cat. no. 11093274910RRID: BC_129243RRID: XM_684743sensory systems

Identifiers

PMID25612302
PMCPMC4412781
OpenAlexW1515746007

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.