Evidence map›Paper›PMID 25611703›Full record

ReviewNeuropathology and applied neurobiology2015

Molecular and cellular pathogenesis of adamantinomatous craniopharyngioma.

Juan Pedro Martinez-Barbera

Open access · hybridAbstract readReview
In one paragraph

Review in Neuropathology and applied neurobiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 86 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Adamantinomatous craniopharyngioma stone: is it a tumor?Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
    Article
  6. Article
  7. Review
  8. The EMT status in the primary tumor of adamantinomatous craniopharyngioma predict postoperative recurrence in children.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. The molecular pathogenesis of craniopharyngiomas.Archives of endocrinology and metabolism · 2023
    Review
  16. Article
  17. Review
  18. Article
  19. Hypothalamic syndrome.Nature reviews. Disease primers · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Juan Pedro Martinez-BarberaBirth Defects Research Centre, Developmental Biology and Cancer Programme, Institute of Child Health, University College London, London, UK.
University College London · GB

Funding

Medical Research Council MR/M000125/1
6 · The paper itself

Abstract

Adamantinomatous craniopharyngiomas (ACPs) are the most common pituitary tumours in children. Although histologically benign, these are clinically aggressive tumours, difficult to manage and associated with poor quality of life for the patients. Several human and mouse studies have provided unequivocal evidence that the over-activation of the WNT/β-catenin signalling pathway underlies the molecular aetiology of these tumours. Recently, research using genetically modified mouse models of human ACP have revealed a critical and unexpected non-cell autonomous role for pituitary stem cells in ACP tumourigenesis, which has expanded the cancer stem cell paradigm. As the result of this basic research, the pathogenesis of ACP is being unveiled, with promising implications for the development of novel treatments against these childhood neoplasms. These benign tumours may additionally represent a unique model to provide insights into the initial steps of oncogenesis.

Indexed as

Animalsbeta CateninCraniopharyngiomaHumansMiceNeoplastic Stem CellsPituitary NeoplasmsStem CellsWnt Signaling Pathwaybeta Cateninadamantinomatous craniopharyngiomapituitarySox2stem cellsWNT pathwayβ-catenin

Identifiers

PMID25611703
PMCPMC4949713
OpenAlexW1496539336

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.