Trial reportPloS one2015
Specific EEG sleep pattern in the prefrontal cortex in primary insomnia.
Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- A systematic review with meta-analysis: Traditional Chinese tuina therapy for insomnia.Frontiers in neuroscience · 2022Pooled it
- Insomnia Symptoms in a Swiss Population-Based Cohort: Prevalence, Clinical Correlates and Polysomnographic Alterations.Journal of sleep research · 2026Article
- Sleep stage-specific effects of 0.75 Hz phase-synchronized rTMS and tACS on delta frequency activity during sleep.Scientific reports · 2026Article
- Nocturnal hypoxia moderates the relationship between rapid eye movement sleep and anxiety.BMC psychiatry · 2025Article
- Sex differences in sleep deficits in mice with an autism-linked Shank3 mutation.Biology of sex differences · 2024Article
- The impact of sleep disorders on brain network connectivity in postpartum women: a functional near-infrared spectroscopy-based study.Frontiers in neurology · 2024Article
- Acute or Chronic Exposure to Corticosterone Promotes Wakefulness in Mice.Brain sciences · 2023Article
- Prefrontal cortex functional connectivity changes during verbal fluency test in adults with short-term insomnia disorder: a functional near-infrared spectroscopy study.Frontiers in neuroscience · 2023Article
- Effects of Transcranial Direct Current Stimulation on Sleep in Athletes: A Protocol of a Randomized Controlled Trial.Journal of clinical medicine · 2022Article
- Sleep macro- and microstructure in breast cancer survivors.Scientific reports · 2022Article
- [Characteristics of Sleep Electroencephalographic Power in Chronic Insomnia Patients].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2022Article
- Prefrontal brain function in patients with chronic insomnia disorder: A pilot functional near-infrared spectroscopy study.Frontiers in neurology · 2022Article
- Sleep Quality and Electroencephalogram Delta Power.Frontiers in neuroscience · 2021Article
- Onset of regular cannabis use and young adult insomnia: an analysis of shared genetic liability.Sleep · 2020Article
- Using Nonlinear Dynamics and Multivariate Statistics to Analyze EEG Signals of Insomniacs with the Intervention of Superficial Acupuncture.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Altered connection properties of important network hubs may be neural risk factors for individuals with primary insomnia.Scientific reports · 2018Article
- Hyperarousal and Beyond: New Insights to the Pathophysiology of Insomnia Disorder through Functional Neuroimaging Studies.Brain sciences · 2017Review
- Regional impairment of intrinsic functional connectivity strength in patients with chronic primary insomnia.Neuropsychiatric disease and treatment · 2017Article
- Frequency-dependent changes in local intrinsic oscillations in chronic primary insomnia: A study of the amplitude of low-frequency fluctuations in the resting state.NeuroImage. Clinical · 2017Article
- Regional homogeneity changes in patients with primary insomnia.European radiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the specific prefrontal activity in comparison to those in the other main cortical areas in primary insomnia patients and in good sleepers.
methodsFourteen primary insomnia patients and 11 good sleepers were included in the analysis. Participants completed one night of polysomnography in the sleep lab. Power spectra were calculated during the NREM (Non-rapid eyes movements) and the REM (Rapid eyes movements) sleep periods at prefrontal, occipital, temporal and central electrode positions.
resultsDuring the NREM sleep, the power spectra did not differ between groups in the prefrontal cortex; while primary insomnia patients exhibited a higher beta power spectrum and a lower delta power spectrum compared to good sleepers in other areas. During the REM sleep, the beta1 power spectrum was lower in the prefrontal cortex in primary insomnia patients compared to good sleepers; while no significant difference between groups was obtained for the other areas.
conclusionsThe present study shows a specific prefrontal sleep pattern during the whole sleep period. In addition, we suggest that primary insomnia patients displayed a dysfunction in the reactivation of the limbic system during the REM sleep and we give additional arguments in favor of a sleep-protection mechanism displayed by primary insomnia patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.