ReviewLife (Basel, Switzerland)2015
RNA synthesis by in vitro selected ribozymes for recreating an RNA world.
Review in Life (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 46 citations in OpenAlex.
- Sequence patterns in RNA replication via the virtual circular genome mechanism.Nucleic acids research · 2026Article
- Origin of the RNA World in Cold Hadean Geothermal Fields Enriched in Zinc and Potassium: Abiogenesis as a Positive Fallout from the Moon-Forming Impact?Life (Basel, Switzerland) · 2025Article
- Intellectual frameworks to understand complex biochemical systems at the origin of life.Nature chemistry · 2025Article
- Biomathematical enzyme kinetics model of prebiotic autocatalytic RNA networks: degenerating parasite-specific hyperparasite catalysts confer parasite resistance and herald the birth of molecular immunity.PLoS computational biology · 2025Article
- On the Re-Creation of Protoribosome Analogues in the Lab.International journal of molecular sciences · 2024Review
- Three Biopolymers and Origin of Life Scenarios.Life (Basel, Switzerland) · 2024Review
- Pioneering role of RNA in the early evolution of life.Genetics and molecular biology · 2024Article
- Computer simulations of Template-Directed RNA Synthesis driven by temperature cycling in diverse sequence mixtures.PLoS computational biology · 2022Article
- Evolution towards increasing complexity through functional diversification in a protocell model of the RNA world.Proceedings. Biological sciences · 2021Article
- The hammerhead self-cleaving motif as a precursor to complex endonucleolytic ribozymes.RNA (New York, N.Y.) · 2021Article
- Social Networking of Quasi-Species Consortia drive Virolution via Persistence.AIMS microbiology · 2021Review
- New Deoxyribozymes for the Native Ligation of RNA.Molecules (Basel, Switzerland) · 2020Article
- Article
- Transitioning to DNA genomes in an RNA world.eLife · 2017Article
- Taming Prebiotic Chemistry: The Role of Heterogeneous and Interfacial Catalysis in the Emergence of a Prebiotic Catalytic/Information Polymer System.Life (Basel, Switzerland) · 2016Review
- Improving the odds: Influence of starting pools on in vitro selection outcomes.Methods (San Diego, Calif.) · 2016Review
- Parasites Sustain and Enhance RNA-Like Replicators through Spatial Self-Organisation.PLoS computational biology · 2016Article
- Collaboration between primitive cell membranes and soluble catalysts.Nature communications · 2016Article
- Thirty-five years of research into ribozymes and nucleic acid catalysis: where do we stand today?F1000Research · 2016Review
- The RNA World: 4,000,000,050 years old.Life (Basel, Switzerland) · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The RNA world hypothesis states that during an early stage of life, RNA molecules functioned as genome and as the only genome-encoded catalyst. This hypothesis is supported by several lines of evidence, one of which is the in vitro selection of catalytic RNAs (ribozymes) in the laboratory for a wide range of reactions that might have been used by RNA world organisms. This review focuses on three types of ribozymes that could have been involved in the synthesis of RNA, the core activity in the self-replication of RNA world organisms. These ribozyme classes catalyze nucleoside synthesis, triphosphorylation, and the polymerization of nucleoside triphosphates. The strengths and weaknesses regarding each ribozyme's possible function in a self-replicating RNA network are described, together with the obstacles that need to be overcome before an RNA world organism can be generated in the laboratory.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.