Evidence map›Paper›PMID 25610882›Full record

ArticleNeurology(R) neuroimmunology & neuroinflammation2015

Markers of JC virus infection in patients with multiple sclerosis under natalizumab therapy.

Valeria Clausi, Simone Giannecchini, Eliana Magnani, Anna Repice, Claudia Mechi, Francesco Martelli, Alberta Azzi, Luca Massacesi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology(R) neuroimmunology & neuroinflammation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Valeria ClausiDepartment of Experimental and Clinical Medicine (V.C., S.G., F.M., A.A.) and Department of Neurosciences, Drugs and Child Health (E.M., L.M.), University of Florence; and Neurology 2 Division (A.R., C.M., L.M.), Careggi University Hospital, Florence, Italy.
Simone GiannecchiniDepartment of Experimental and Clinical Medicine (V.C., S.G., F.M., A.A.) and Department of Neurosciences, Drugs and Child Health (E.M., L.M.), University of Florence; and Neurology 2 Division (A.R., C.M., L.M.), Careggi University Hospital, Florence, Italy.
Eliana MagnaniDepartment of Experimental and Clinical Medicine (V.C., S.G., F.M., A.A.) and Department of Neurosciences, Drugs and Child Health (E.M., L.M.), University of Florence; and Neurology 2 Division (A.R., C.M., L.M.), Careggi University Hospital, Florence, Italy.
Anna RepiceDepartment of Experimental and Clinical Medicine (V.C., S.G., F.M., A.A.) and Department of Neurosciences, Drugs and Child Health (E.M., L.M.), University of Florence; and Neurology 2 Division (A.R., C.M., L.M.), Careggi University Hospital, Florence, Italy.
Claudia MechiDepartment of Experimental and Clinical Medicine (V.C., S.G., F.M., A.A.) and Department of Neurosciences, Drugs and Child Health (E.M., L.M.), University of Florence; and Neurology 2 Division (A.R., C.M., L.M.), Careggi University Hospital, Florence, Italy.
Francesco MartelliDepartment of Experimental and Clinical Medicine (V.C., S.G., F.M., A.A.) and Department of Neurosciences, Drugs and Child Health (E.M., L.M.), University of Florence; and Neurology 2 Division (A.R., C.M., L.M.), Careggi University Hospital, Florence, Italy.
Alberta AzziDepartment of Experimental and Clinical Medicine (V.C., S.G., F.M., A.A.) and Department of Neurosciences, Drugs and Child Health (E.M., L.M.), University of Florence; and Neurology 2 Division (A.R., C.M., L.M.), Careggi University Hospital, Florence, Italy.
Luca MassacesiDepartment of Experimental and Clinical Medicine (V.C., S.G., F.M., A.A.) and Department of Neurosciences, Drugs and Child Health (E.M., L.M.), University of Florence; and Neurology 2 Division (A.R., C.M., L.M.), Careggi University Hospital, Florence, Italy.
Azienda Ospedaliero-Universitaria Careggi · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the frequency of JC polyomavirus (JCPyV) infection and anti-JCPyV antibodies in patients with multiple sclerosis under natalizumab therapy.

methodsPresence of anti-JCPyV antibodies and JCPyV DNA was analyzed in 39 patients with relapsing-remitting multiple sclerosis undergoing natalizumab therapy. Anti-JCPyV antibodies were evaluated in serum by a 2-step virus-like particle-based ELISA assay (Stratify), and JCPyV DNA was evaluated in peripheral blood mononuclear cells, plasma, and urine by quantitative PCR. The anti-JCPyV antibodies were evaluated in serum samples collected at the same time or later than those collected for DNA analysis.

resultsJCPyV DNA was detected in 59% of patients, and anti-JCPyV antibodies were present in 67%. JCPyV DNA occurred more often in blood than in urine. Anti-JCPyV antibodies were observed in 70% of the JCPyV-infected patients, and JCPyV DNA was detected in 50% of the patients without anti-JCPyV antibodies. When JCPyV DNA was investigated in blood and urine the frequency of infection was higher than previously described.

conclusionUnder these experimental conditions, with respect to the observed frequency of JCPyV infection, the sensitivity of the anti-JCPyV antibody assay was lower than expected.

Identifiers

PMID25610882
PMCPMC4299884
OpenAlexW2123767586

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.