ArticleJournal of diabetes research2014
Hyperglycemia inhibits complement-mediated immunological control of S. aureus in a rat model of peritonitis.
Article in Journal of diabetes research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- Assessing the predictive value of time-in-range level for the risk of postoperative infection in patients with type 2 diabetes: a cohort study.Frontiers in endocrinology · 2025Article
- Effect of the ketone beta-hydroxybutyrate on markers of inflammation and immune function in adults with type 2 diabetes.Clinical and experimental immunology · 2024Article
- Naturally acquired antibodies against 4 Streptococcus pneumoniae serotypes in Pakistani adults with type 2 diabetes mellitus.PloS one · 2024Article
- Diabetes and Cancer: A Twisted Bond.Oncology reviews · 2024Review
- The Influence of Metabolism on Immune Response: A Journey to Understand Immunometabolism in the Context of Viral Infection.Viruses · 2023Review
- Advancements of fish-derived peptides for mucormycosis: a novel strategy to treat diabetic compilation.Molecular biology reports · 2023Review
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- Epidemiological Features and Impact of High Glucose Level on Virulence Gene Expression and Serum Resistance ofInfection and drug resistance · 2023Article
- SARS-CoV-2 infection and diabetes: Pathophysiological mechanism of multi-system organ failure.World journal of virology · 2022Review
- Glucose supply and glycolysis inhibition shape the clinical fate of Staphylococcus epidermidis-infected preterm newborns.JCI insight · 2022Article
- Diabetes Mellitus and Dental Implants: A Systematic Review and Meta-Analysis.Materials (Basel, Switzerland) · 2022Review
- Macroscopic and histopathological features of acute peritoneal infection in diabetic and euglycemic Wistar rats.Pediatric endocrinology, diabetes, and metabolism · 2022Article
- Adaptation ofToxins · 2021Article
- A Machine-Generated View of the Role of Blood Glucose Levels in the Severity of COVID-19.Frontiers in public health · 2021Article
- Article
- Glucose transport in lymphocytes.Pflugers Archiv : European journal of physiology · 2020Review
- Type 2 Diabetes and its Impact on the Immune System.Current diabetes reviews · 2020Review
- Low prevalence of rheumatoid arthritis among patients with pre-existing type 2 diabetes mellitus.Annals of translational medicine · 2018Article
- Hyperglycemia during first-line R-CHOP or dose adjusted R-EPOCH chemotherapy for non-Hodgkin lymphoma is prevalent and associated with chemotherapy alteration - a retrospective study.Leukemia & lymphoma · 2018Article
- Cytokine and Adhesion Molecule Expression Induced by Different Strains ofFrontiers in immunology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hyperglycemia from diabetes is associated with increased risk of infection from S. aureus and increased severity of illness. Previous work in our laboratory demonstrated that elevated glucose (>6 mM) dramatically inhibited S. aureus-initiated complement-mediated immune effectors. Here we report in vivo studies evaluating the extent to which a hyperglycemic environment alters complement-mediated control of S. aureus infection in a rat peritonitis model. Rats were treated with streptozocin to induce diabetes or sham-treated and then inoculated i.p. with S. aureus. Rats were euthanized and had peritoneal lavage at 2 or 24 hours after infection to evaluate early and late complement-mediated effects. Hyperglycemia decreased the influx of IgG and complement components into the peritoneum in response to S. aureus infection and decreased anaphylatoxin generation. Hyperglycemia decreased C4-fragment and C3-fragment opsonization of S. aureus recovered in peritoneal fluids, compared with euglycemic or insulin-rescued rats. Hyperglycemic rats showed decreased phagocytosis efficiency compared with euglycemic rats, which correlated inversely with bacterial survival. These results suggest that hyperglycemia inhibited humoral effector recruitment, anaphylatoxin generation, and complement-mediated opsonization of S. aureus, suggesting that hyperglycemic inhibition of complement effectors may contribute to the increased risk and severity of S. aureus infections in diabetic patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.