ArticleNeuroImage. Clinical2015
Altered cognition-related brain activity and interactions with acute pain in migraine.
Article in NeuroImage. Clinical, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 69 citations in OpenAlex.
- Trial
- Interictal and Ictal Cognitive Performance in Episodic and Chronic Migraine.European journal of neurology · 2026Article
- The impact of pain on memory: a study in chronic low back pain and migraine patients.Brain communications · 2026Article
- Cognitive Reserve and Its Associations with Pain, Anxiety, and Depression in Patients with Chronic Migraine: A Retrospective Study.Journal of clinical medicine · 2025Article
- Migraine and cognitive dysfunction: a narrative review.The journal of headache and pain · 2024Review
- Cognitive assessment during the phases of a spontaneous migraine: a prospective cohort study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Pathological claustrum activity drives aberrant cognitive network processing in human chronic pain.Current biology : CB · 2024Article
- Working memory during spontaneous migraine attacks: an fMRI study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Structural and functional changes of anterior cingulate cortex subregions in migraine without aura: relationships with pain sensation and pain emotion.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Pathological claustrum activity drives aberrant cognitive network processing in human chronic pain.bioRxiv : the preprint server for biology · 2023Article
- Behavioral modeling and neuroimaging of impaired risky decision making in patients with chronic musculoskeletal pain.Neurophotonics · 2023Article
- Neuropsychological and Neuropsychiatric Features of Chronic Migraine Patients during the Interictal Phase.Journal of clinical medicine · 2023Article
- Nociceptive stress interferes with neural processing of cognitive stimuli in Gulf War Veterans with chronic musculoskeletal pain.Life sciences · 2021Article
- Functional connectivity of the visual cortex differentiates anxiety comorbidity from episodic migraineurs without aura.The journal of headache and pain · 2021Article
- Differential alteration of fMRI signal variability in the ascending trigeminal somatosensory and pain modulatory pathways in migraine.The journal of headache and pain · 2021Article
- Acupuncture Modulation Effect on Pain Processing Patterns in Patients With Migraine Without Aura.Frontiers in neuroscience · 2021Article
- Multi-channel hierarchy functional integration analysis between large-scale brain networks for migraine: An fMRI study.NeuroImage. Clinical · 2020Article
- Age and pain differences in non-verbal fluency performance: Associations with cortical thickness and subcortical volumes.Experimental gerontology · 2019Article
- Cognition and Cognitive Impairment in Migraine.Current pain and headache reports · 2019Review
- Expertise Modulates Students' Perception of Pain From a Self-Perspective: Quasi-Experimental Study.Journal of medical Internet research · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Little is known about the effect of migraine on neural cognitive networks. However, cognitive dysfunction is increasingly being recognized as a comorbidity of chronic pain. Pain appears to affect cognitive ability and the function of cognitive networks over time, and decrements in cognitive function can exacerbate affective and sensory components of pain. We investigated differences in cognitive processing and pain-cognition interactions between 14 migraine patients and 14 matched healthy controls using an fMRI block-design with two levels of task difficulty and concurrent heat (painful and not painful) stimuli. Across groups, cognitive networks were recruited in response to a difficult cognitive task, and a pain-task interaction was found in the right (contralateral to pain stimulus) posterior insula (pINS), such that activity was modulated by decreasing the thermal pain stimulus or by engaging the difficult cognitive task. Migraine patients had less task-related deactivation within the left dorsolateral prefrontal cortex (DLPFC) and left dorsal anterior midcingulate cortex (aMCC) compared to controls. These regions have been reported to have decreased cortical thickness and cognitive-related deactivation within other pain populations, and are also associated with pain regulation, suggesting that the current findings may reflect altered cognitive function and top-down regulation of pain. During pain conditions, patients had decreased task-related activity, but more widespread task-related reductions in pain-related activity, compared to controls, suggesting cognitive resources may be diverted from task-related to pain-reduction-related processes in migraine. Overall, these findings suggest that migraine is associated with altered cognitive-related neural activity, which may reflect altered pain regulatory processes as well as broader functional restructuring.
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