Trial reportNeuroImage. Clinical2015
Training-induced improvements in postural control are accompanied by alterations in cerebellar white matter in brain injured patients.
Trial report in NeuroImage. Clinical, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- The second decade of DTI in TBI Part 2: a systematic review of moderate and severe TBI.Frontiers in neurologyPooled it
- Structural brain correlates of balance control in children with cerebral palsy: baseline correlations and effects of training.Brain structure & function · 2025Trial
- Effects of a rapid-resisted elliptical training program on motor, cognitive and neurobehavioral functioning in adults with chronic traumatic brain injury.Experimental brain research · 2016Trial
- Cerebellar volume alterations are associated with cognitive dysfunction and fatigue in patients with systemic lupus erythematosus.BMC rheumatology · 2026Article
- Correlations Between Morpho-structural Properties of the Brain and Cognitive and Motor Deficits in Individuals with Traumatic Brain Injury.Neurotrauma reports · 2025Article
- Review
- Consensus Paper: Ataxic Gait.Cerebellum (London, England) · 2023Article
- How we get a grip: Microstructural neural correlates of manual grip strength in children.NeuroImage · 2023Article
- Associations between white matter integrity and postural control in adults with traumatic brain injury.PloS one · 2023Article
- White matter tract strength correlates with therapy outcome in persistent developmental stuttering.Human brain mapping · 2022Article
- The Development of Hindlimb Postural Asymmetry Induced by Focal Traumatic Brain Injury Is Not Related to Serotonin 2A/C Receptor Expression in the Spinal Cord.International journal of molecular sciences · 2022Article
- Neurite dispersion and density mediates the relationship between cardiorespiratory fitness and cognition in healthy younger adults.Neuropsychologia · 2022Article
- Graph-theoretical analysis of EEG functional connectivity during balance perturbation in traumatic brain injury: A pilot study.Human brain mapping · 2021Article
- Neurobiological and behavioural outcomes of biofeedback-based training in autism: a randomized controlled trial.Brain communications · 2021Article
- Detecting axonal injury in individual patients after traumatic brain injury.Brain : a journal of neurology · 2021Article
- Longitudinal fixel-based analysis reveals restoration of white matter alterations following balance training in young brain-injured patients.NeuroImage. Clinical · 2021Article
- Drum training induces long-term plasticity in the cerebellum and connected cortical thickness.Scientific reports · 2020Article
- Drumming Motor Sequence Training Induces Apparent Myelin Remodelling in Huntington's Disease: A Longitudinal Diffusion MRI and Quantitative Magnetization Transfer Study.Journal of Huntington's disease · 2020Article
- Remotely Supervised Home-Based Intensive Exercise Intervention to Improve Balance, Functional Mobility, and Physical Activity in Survivors of Moderate or Severe Traumatic Brain Injury: Protocol for a Mixed Methods Study.JMIR research protocols · 2019Article
- Altered White Matter Integrity after Mild to Moderate Traumatic Brain Injury.Journal of clinical medicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated whether balance control in young TBI patients can be promoted by an 8-week balance training program and whether this is associated with neuroplastic alterations in brain structure. The cerebellum and cerebellar peduncles were selected as regions of interest because of their importance in postural control as well as their vulnerability to brain injury. Young patients with moderate to severe TBI and typically developing (TD) subjects participated in balance training using PC-based portable balancers with storage of training data and real-time visual feedback. An additional control group of TD subjects did not attend balance training. Mean diffusivity and fractional anisotropy were determined with diffusion MRI scans and were acquired before, during (4 weeks) and at completion of training (8 weeks) together with balance assessments on the EquiTest® System (NeuroCom) which included the Sensory Organization Test, Rhythmic Weight Shift and Limits of Stability protocols. Following training, TBI patients showed significant improvements on all EquiTest protocols, as well as a significant increase in mean diffusivity in the inferior cerebellar peduncle. Moreover, in both training groups, diffusion metrics in the cerebellum and/or cerebellar peduncles at baseline were predictive of the amount of performance increase after training. Finally, amount of training-induced improvement on the Rhythmic Weight Shift test in TBI patients was positively correlated with amount of change in fractional anisotropy in the inferior cerebellar peduncle. This suggests that training-induced plastic changes in balance control are associated with alterations in the cerebellar white matter microstructure in TBI patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.