ArticleNeuroImage. Clinical2015
Reduced hippocampal volume and hypothalamus-pituitary-adrenal axis function in first episode psychosis: evidence for sex differences.
Article in NeuroImage. Clinical, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Is psychosis a multisystem disorder? A meta-review of central nervous system, immune, cardiometabolic, and endocrine alterations in first-episode psychosis and perspective on potential models.Molecular psychiatry · 2019Pooled it
- Hippocampal volume and persistent distressing psychotic-like experiences across early adolescence: the moderating role of physical activity.Schizophrenia research · 2026Article
- Social withdrawal and hippocampal volume among adolescents at clinical high risk for psychosis and healthy comparisons: The moderating role of neighborhood residential stability.Schizophrenia research · 2026Article
- Corticosteroid-Induced neuropsychiatric manifestations: From pathophysiology to management.Psychopharmacology · 2026Review
- Sex differences in prevalence and clinical correlates for psychotic symptoms in first-episode drug-naïve patients with bipolar disorder: a cross-sectional study.Annals of general psychiatry · 2026Article
- Catching the Storm Before It Breaks: Advancing Early Diagnosis and Intervention in Bipolar Disorder.Life (Basel, Switzerland) · 2025Review
- Social stress, cortisol awakening response and sex: association with hippocampus and amygdala volume.Biology of sex differences · 2025Article
- Reduced hippocampal volume unmasks distinct impacts of cumulative adverse childhood events (ACEs) on psychotic-like experiences in late childhood and early adolescence.Psychoneuroendocrinology · 2024Article
- Relations of Lifetime Perceived Stress and Basal Cortisol With Hippocampal Volume Among Healthy Adolescents and Those at Clinical High Risk for Psychosis: A Structural Equation Modeling Approach.Biological psychiatry · 2024Article
- Exploring causal mechanisms of psychosis risk.Neuroscience and biobehavioral reviews · 2024Review
- The Translational Future of Stress Neurobiology and Psychosis Vulnerability: A Review of the Evidence.Current neuropharmacology · 2024Review
- Altered Sex Differences in Hippocampal Subfield Volumes in Schizophrenia.Schizophrenia bulletin · 2024Article
- Hippocampal subfields, daily stressors, and resting cortisol in individuals at clinical high-risk for psychosis.Psychoneuroendocrinology · 2023Article
- Males and females with first episode psychosis present distinct profiles of social cognition and metacognition.European archives of psychiatry and clinical neuroscience · 2022Article
- The Poly I:C maternal immune stimulation model shows unique patterns of brain metabolism, morphometry, and plasticity in female rats.Frontiers in behavioral neuroscience · 2022Article
- Cortisol and dehydroepiandrosterone sulfate in patients with schizophrenia spectrum disorders with respect to cognitive performance.Comprehensive psychoneuroendocrinology · 2021Article
- Neuroimaging Heterogeneity in Psychosis: Neurobiological Underpinnings and Opportunities for Prognostic and Therapeutic Innovation.Biological psychiatry · 2020Review
- Neurobiological mechanisms underlying sex-related differences in stress-related disorders: Effects of neuroactive steroids on the hippocampus.Frontiers in neuroendocrinology · 2019Review
- Linking persistent negative symptoms to amygdala-hippocampus structure in first-episode psychosis.Translational psychiatry · 2017Article
- Neuroanatomical and Symptomatic Sex Differences in Individuals at Clinical High Risk for Psychosis.Frontiers in psychiatry · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHippocampal volume (HV) decline is an important marker of psychosis and has been associated with hypothalamus-pituitary-adrenal (HPA) axis dysregulation in various disorders. Given recent findings of sex differences in HPA axis function in psychosis, the current study investigated differences in HV in male and female first episode psychosis (FEP) patients and controls and the interaction of HV with the cortisol awakening response (CAR) and symptoms.
methodsFifty-eight patients with a diagnosis of FEP (39 men, 19 women) and 27 healthy community controls (15 men, 12 women) underwent structural magnetic resonance imaging (MRI) on a 1.5 T scanner. Hippocampal volume was determined using previously established segmentation protocols. Saliva samples for cortisol assessment were collected at 0, 30 and 60 min after awakening. Psychotic symptoms were assessed with the Scale for Assessment of Positive Symptoms (SAPS), the Scale for Assessment of Negative Symptoms (SANS) and the Global Assessment of Functioning (GAF) scale.
resultsMale patients had significantly smaller left and right HVs compared to male controls, which appeared to be secondary to global brain volume differences. However, even when controlling for overall brain size, male patients showed smaller HV compared to female patients. The CAR was significantly lower in male patients compared to male controls and female patients. Only in male patients, smaller left HV was significantly associated with a blunted CAR, and smaller HV bilaterally was related to positive psychotic symptoms and lower levels of functioning.
conclusionsWe propose that reduced hippocampal volume and an attenuated cortisol awakening response are related markers of increased stress vulnerability in male psychosis patients and that both contribute to the unfavorable clinical picture in men.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.