ArticleNeuroImage. Clinical2015
Individual differences in symptom severity and behavior predict neural activation during face processing in adolescents with autism.
Article in NeuroImage. Clinical, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- A quantitative meta-analysis of face recognition deficits in autism: 40 years of research.Psychological bulletin · 2021Pooled it
- Patterns of neural activity in response to threatening faces are predictive of autistic traits: modulatory effects of oxytocin receptor genotype.Translational psychiatry · 2024Article
- Age-related differences in the intrinsic connectivity of the hippocampus and ventral temporal lobe in autistic individuals.Frontiers in human neuroscience · 2024Article
- Functional connectivity of the human face network exhibits right hemispheric lateralization from infancy to adulthood.Scientific reports · 2023Article
- Replicable Patterns of Memory Impairments in Children With Autism and Their Links to Hyperconnected Brain Circuits.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- White and gray matter correlates of theory of mind in autism: a voxel-based morphometry study.Brain structure & function · 2023Article
- Neurobiological correlates and attenuated positive social intention attribution during laughter perception associated with degree of autistic traits.Journal of neural transmission (Vienna, Austria : 1996) · 2023Article
- The Privileged Status of Peer Faces: Subordinate-level Neural Representations of Faces in Emerging Adults.Journal of cognitive neuroscience · 2023Article
- Article
- Effects of sensory distraction and salience priming on emotion identification in autism: an fMRI study.Journal of neurodevelopmental disorders · 2021Article
- Atypical spatiotemporal activation of cerebellar lobules during emotional face processing in adolescents with autism.Human brain mapping · 2021Article
- A Novel Unit-Based Personalized Fingerprint Feature Selection Strategy for Dynamic Functional Connectivity Networks.Frontiers in neuroscience · 2021Article
- Face individual identity recognition: a potential endophenotype in autism.Molecular autism · 2020Article
- Altered Intrinsic Functional Connectivity of the Primary Visual Cortex in Patients with Neovascular Glaucoma: A Resting-State Functional Magnetic Resonance Imaging Study.Neuropsychiatric disease and treatment · 2020Article
- Puberty and functional brain development in humans: Convergence in findings?Developmental cognitive neuroscience · 2019Review
- Evaluating the organizational structure and specificity of network topology within the face processing system.Human brain mapping · 2019Article
- Enhancing the representation of functional connectivity networks by fusing multi-view information for autism spectrum disorder diagnosis.Human brain mapping · 2019Article
- Article
- Cortical responses to dynamic emotional facial expressions generalize across stimuli, and are sensitive to task-relevance, in adults with and without Autism.Cortex; a journal devoted to the study of the nervous system and behavior · 2018Article
- Face perception and learning in autism spectrum disorders.Quarterly journal of experimental psychology (2006) · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Despite the impressive literature describing atypical neural activation in visuoperceptual face processing regions in autism, almost nothing is known about whether these perturbations extend to more affective regions in the circuitry and whether they bear any relationship to symptom severity or atypical behavior. Using fMRI, we compared face-, object-, and house-related activation in adolescent males with high-functioning autism (HFA) and typically developing (TD) matched controls. HFA adolescents exhibited hypo-activation throughout the core visuoperceptual regions, particularly in the right hemisphere, as well as in some of the affective/motivational face-processing regions, including the posterior cingulate cortex and right anterior temporal lobe. Conclusions about the relative hyper- or hypo-activation of the amygdala depended on the nature of the contrast that was used to define the activation. Individual differences in symptom severity predicted the magnitude of face activation, particularly in the right fusiform gyrus. Also, among the HFA adolescents, face recognition performance predicted the magnitude of face activation in the right anterior temporal lobe, a region that supports face individuation in TD adults. Our findings reveal a systematic relation between the magnitude of neural dysfunction, severity of autism symptoms, and variation in face recognition behavior in adolescents with autism. In so doing, we uncover brain-behavior relations that underlie one of the most prominent social deficits in autism and help resolve discrepancies in the literature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.