Evidence map›Paper›PMID 25610735›Full record

ArticleOncoimmunology

COMMD1 regulates inflammation and colitis-associated cancer progression.

Haiying Li, Ezra Burstein

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Haiying LiDepartments of Internal Medicine; UT Southwestern Medical Center ; Dallas, TX USA.
Ezra BursteinDepartments of Internal Medicine; UT Southwestern Medical Center ; Dallas, TX USA ; Molecular Biology; UT Southwestern Medical Center ; Dallas, TX USA.
Southwestern Medical CenterThe University of Texas Southwestern Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

NF-κB is a master transcriptional regulator of inflammation that plays an important role in oncogenesis, particularly in tumors that arise in the context of inflammation. Copper metabolism MURR1 domain-containing 1 (COMMD1) is a negative regulator of NF-κB. Recent genetic-based studies in both mice and human patients indicate that COMMD1 has an important role in controlling intestinal inflammation and constraining progression to colitis-associated cancer.

Indexed as

BMDM, bone marrow derived myeloid cellsCAC, colitis-associated cancercolitis-associated cancerCOMMD1COMMD1, copper metabolism MURR1 domain containing 1GWAS, genome wide association studiesIBD, inflammatory bowel diseaseIKK, IκB kinaseinflammationinflammatory bowel diseaseIκB, inhibitor of κBK/O, knockoutLPS, lipopolysaccharideMye-K/O, myeloid-specific Commd1 knockoutNF-κBNF-κB, nuclear factor-κBSNP, single nucleotide polymorphismubiquitinationWT, wild-type

Identifiers

PMID25610735
PMCPMC4292209
OpenAlexW2010583650

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.