ArticleJournal of obesity2014
Identification of novel clinical factors associated with hepatic fat accumulation in extreme obesity.
Article in Journal of obesity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Integrating genetic and transcriptomic data to identify genes underlying obesity risk loci.International journal of obesity (2005) · 2025Article
- Differentially expressed mRNAs and lncRNAs shared between activated human hepatic stellate cells and nash fibrosis.Biochemistry and biophysics reports · 2020Article
- Chemokine ligand 20 (CCL20) expression increases with NAFLD stage and hepatic stellate cell activation and is regulated by miR-590-5p.Cytokine · 2019Article
- AEBP1 expression increases with severity of fibrosis in NASH and is regulated by glucose, palmitate, and miR-372-3p.PloS one · 2019Article
- Differentially methylated loci in NAFLD cirrhosis are associated with key signaling pathways.Clinical epigenetics · 2018Article
- Transcriptomic Profiling of Obesity-Related Nonalcoholic Steatohepatitis Reveals a Core Set of Fibrosis-Specific Genes.Journal of the Endocrine Society · 2018Article
- CCL20 is up-regulated in non-alcoholic fatty liver disease fibrosis and is produced by hepatic stellate cells in response to fatty acid loading.Journal of translational medicine · 2018Article
- Altered expression of MALAT1 lncRNA in nonalcoholic steatohepatitis fibrosis regulates CXCL5 in hepatic stellate cells.Translational research : the journal of laboratory and clinical medicine · 2017Article
- A multi-component classifier for nonalcoholic fatty liver disease (NAFLD) based on genomic, proteomic, and phenomic data domains.Scientific reports · 2017Article
- The importance of prediction model validation and assessment in obesity and nutrition research.International journal of obesity (2005) · 2016Review
- The impact of obstructive sleep apnea on nonalcoholic fatty liver disease in patients with severe obesity.Obesity (Silver Spring, Md.) · 2016Article
- Circulating microRNAs in nonalcoholic fatty liver disease.Expert review of gastroenterology & hepatology · 2016Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesThe accumulation of lipids stored as excess triglycerides in the liver (steatosis) is highly prevalent in obesity and has been associated with several clinical characteristics, but most studies have been based on relatively small sample sizes using a limited set of variables. We sought to identify clinical factors associated with liver fat accumulation in a large cohort of patients with extreme obesity.
methodsWe analyzed 2929 patients undergoing intraoperative liver biopsy during a primary bariatric surgery. Univariate and multivariate regression modeling was used to identify associations with over 200 clinical variables with the presence of any fat in the liver and with moderate to severe versus mild fat accumulation.
resultsA total of 19 data elements were associated with the presence of liver fat and 11 with severity of liver fat including ALT and AST, plasma lipid, glucose, and iron metabolism variables, several medications and laboratory measures, and sleep apnea. The accuracy of a multiple logistic regression model for presence of liver fat was 81% and for severity of liver fat accumulation was 77%.
conclusionsA limited set of clinical factors can be used to model hepatic fat accumulation with moderate accuracy and may provide potential mechanistic insights in the setting of extreme obesity.
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