ArticleIUCrJ2015
Determination of crystallographic intensities from sparse data.
Article in IUCrJ, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- 3D Nanocrystallography and the Imperfect Molecular Lattice.Annual review of physical chemistry · 2024Review
- Article
- SPIND-TC: an indexing method for two-color X-ray diffraction data.Acta crystallographica. Section A, Foundations and advances · 2020Article
- Article
- Article
- Article
- Reconstructing three-dimensional protein crystal intensities from sparse unoriented two-axis X-ray diffraction patterns.Journal of applied crystallography · 2017Article
- EIGER detector: application in macromolecular crystallography.Acta crystallographica. Section D, Structural biology · 2016Article
- Article
- Article
- Crystallography is more than crystal structures.IUCrJ · 2015Article
- Serial crystallography for the masses?IUCrJ · 2015Article
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Authors and funding
6 authors.
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Abstract
X-ray serial microcrystallography involves the collection and merging of frames of diffraction data from randomly oriented protein microcrystals. The number of diffracted X-rays in each frame is limited by radiation damage, and this number decreases with crystal size. The data in the frame are said to be sparse if too few X-rays are collected to determine the orientation of the microcrystal. It is commonly assumed that sparse crystal diffraction frames cannot be merged, thereby setting a lower limit to the size of microcrystals that may be merged with a given source fluence. The EMC algorithm [Loh & Elser (2009 ▶), Phys. Rev. E, 80, 026705] has previously been applied to reconstruct structures from sparse noncrystalline data of objects with unknown orientations [Philipp et al. (2012 ▶), Opt. Express, 20, 13129-13137; Ayyer et al. (2014 ▶), Opt. Express, 22, 2403-2413]. Here, it is shown that sparse data which cannot be oriented on a per-frame basis can be used effectively as crystallographic data. As a proof-of-principle, reconstruction of the three-dimensional diffraction intensity using sparse data frames from a 1.35 kDa molecule crystal is demonstrated. The results suggest that serial microcrystallography is, in principle, not limited by the fluence of the X-ray source, and collection of complete data sets should be feasible at, for instance, storage-ring X-ray sources.
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