Evidence map›Paper›PMID 25610437›Full record

ReviewFrontiers in microbiology2014

Post-translational modification of P II signal transduction proteins.

Mike Merrick

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Crystal structures of adenylylated and unadenylylated PActa crystallographica. Section D, Structural biology · 2021
    Article
  7. Article
  8. Article
  9. Article
  10. NADThe Journal of biological chemistry · 2020
    Article
  11. Article
  12. Review
  13. Protein post-translational modifications in bacteria.Nature reviews. Microbiology · 2019
    Review
  14. The Signal Transduction Protein PFrontiers in microbiology · 2019
    Article
  15. Article
  16. Review
  17. The Nitrogen Regulatory PII Protein (GlnB) andJournal of bacteriology · 2018
    Article
  18. The PFrontiers in molecular biosciences · 2018
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Mike MerrickDepartment of Molecular Microbiology, John Innes Centre Norwich, UK.
John Innes Centre · GB

Funding

Biotechnology and Biological Sciences Research Council BB/E022308/1
6 · The paper itself

Abstract

The PII proteins constitute one of the most widely distributed families of signal transduction proteins in nature. They are pivotal players in the control of nitrogen metabolism in bacteria and archaea, and are also found in the plastids of plants. Quite remarkably PII proteins control the activities of a diverse range of enzymes, transcription factors and membrane transport proteins, and in all known cases they achieve their regulatory effect by direct interaction with their target. PII proteins in the Proteobacteria and the Actinobacteria are subject to post-translational modification by uridylylation or adenylylation respectively, whilst in some Cyanobacteria they can be modified by phosphorylation. In all these cases the protein's modification state is influenced by the cellular nitrogen status and is thought to regulate its activity. However, in many organisms there is no evidence for modification of PII proteins and indeed the ability of these proteins to respond to the cellular nitrogen status is fundamentally independent of post-translational modification. In this review we explore the role of post-translational modification in PII proteins in the light of recent studies.

Indexed as

adenylylationphosphorylationpII proteinpost-translational modificationuridylylation

Identifiers

PMID25610437
PMCPMC4285133
OpenAlexW1999234023

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.