ArticleFrontiers in endocrinology2014
Impact of Maternal Melatonin Suppression on Amount and Functionality of Brown Adipose Tissue (BAT) in the Newborn Sheep.
Article in Frontiers in endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Body surface temperatures as biomarkers of physiological environmental adaptation in wild birds and mammals.Biological reviews of the Cambridge Philosophical Society · 2026Pooled it
- Brown adipose tissue in ruminants: development, thermogenic function, and nutritional regulation.Frontiers in veterinary science · 2026Review
- Mapping the Research Landscape of Climate Change and its Impact on Pregnancy and Neonatal Outcomes: A Bibliometric Analysis.Journal of epidemiology and global health · 2025Article
- Does Melatonin Enhance Twin Lamb Survival in Commercial Merino Flocks in Australia?Animals : an open access journal from MDPI · 2025Article
- Impact of an extended light regimen imposed during nursery period on the performance and lipid metabolism of weanling pigs.Animal bioscience · 2025Article
- Evaluation of Melatonin and its Nanostructures Effects on Skin Disorders Focused on Wound Healing.Mini reviews in medicinal chemistry · 2024Review
- Intergenerational impact of dietary protein restriction in dairy ewes on epigenetic marks in the perirenal fat of their suckling lambs.Scientific reports · 2023Article
- Strategies for Hypothermia Compensation in Altricial and Precocial Newborn Mammals and Their Monitoring by Infrared Thermography.Veterinary sciences · 2022Review
- Implanting melatonin at lambing enhances lamb growth and maintains high fat content in milk.Veterinary research communications · 2021Article
- The Circadian Physiology: Implications in Livestock Health.International journal of molecular sciences · 2021Review
- Melatonin Regulates Differentiation of Sheep Brown Adipocyte Precursor CellsFrontiers in veterinary science · 2021Article
- Maternal Chronodisruption Throughout Pregnancy Impairs Glucose Homeostasis and Adipose Tissue Physiology in the Male Rat Offspring.Frontiers in endocrinology · 2021Article
- Supplementing Merino ewes with melatonin during the last half of pregnancy improves tolerance of prolonged parturition and survival of second-born twin lambs.Journal of animal science · 2020Article
- Neonatal lamb mortality: major risk factors and the potential ameliorative role of melatonin.Journal of animal science and biotechnology · 2020Review
- Maternal melatonin implants improve twin Merino lamb survival.Journal of animal science · 2020Article
- Elucidating the Regulatory Role of Melatonin in Brown, White, and Beige Adipocytes.Advances in nutrition (Bethesda, Md.) · 2020Review
- New Insights Into the Evolutionary History of Melatonin Receptors in Vertebrates, With Particular Focus on Teleosts.Frontiers in endocrinology · 2020Review
- Simulated shift work disrupts maternal circadian rhythms and metabolism, and increases gestation length in sheep.The Journal of physiology · 2019Article
- Melatonin reduces intramuscular fat deposition by promoting lipolysis and increasing mitochondrial function.Journal of lipid research · 2019Article
- Effects of Melatonin on the Defense to Acute Hypoxia in Newborn Lambs.Frontiers in endocrinology · 2019Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In human and sheep newborns, brown adipose tissue (BAT) accrued during fetal development is used for newborn thermogenesis. Here, we explored the role of maternal melatonin during gestation on the amount and functionality of BAT in the neonate. We studied BAT from six lambs gestated by ewes exposed to constant light from 63% gestation until delivery to suppress melatonin (LL), six lambs gestated by ewes exposed to LL but receiving daily oral melatonin (12 mg at 1700 h, LL + Mel) and another six control lambs gestated by ewes maintained in 12 h light:12 h dark (LD). Lambs were instrumented at 2 days of age. At 4-6 days of age, they were exposed to 24°C (thermal neutrality conditions) for 1 h, 4°C for 1 h, and 24°C for 1 h. Afterward, lambs were euthanized and BAT was dissected for mRNA measurement, histology, and ex vivo experiments. LL newborns had lower central BAT and skin temperature under thermal neutrality and at 4°C, and higher plasma norepinephrine concentration than LD newborns. In response to 4°C, they had a pronounced decrease in skin temperature and did not increase plasma glycerol. BAT weight in LL newborns was about half of that of LD newborns. Ex vivo, BAT from LL newborns showed increased basal lipolysis and did not respond to NE. In addition, expression of adipogenic/thermogenic genes (UCP1, ADBR3, PPARγ, PPARα, PGC1α, C/EBPβ, and perilipin) and of the clock genes Bmal1, Clock, and Per2 was increased. Remarkably, the effects observed in LL newborns were absent in LL + Mel newborns. Thus, our results support that maternal melatonin during gestation is important in determining amount and normal functionality of BAT in the neonate.
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Registered trials
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