ReviewFrontiers in neurology2014
Early intervention to improve hand function in hemiplegic cerebral palsy.
Review in Frontiers in neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02841319 (The Effects of Virtual Reality Therapy Compared With Home Exercise Program on Upper Extremity Functions in Children With Hemiplegic Cerebral Palsy), which is not on this map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of Virtual Reality Therapy Compared With Home Exercise Program on Upper Extremity Functions in Children With Hemiplegic Cerebral Palsy: a Randomized Controlled Trial
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Noninvasive brain stimulation for upper limb motor activity in children and young adults with cerebral palsy and pediatric stroke: a systematic review and meta-analysis.Journal of neuroengineering and rehabilitation · 2025Pooled it
- The use of virtual reality in the stimulation of manual function in children with cerebral palsy: a systematic review.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2023Pooled it
- Effects of upper extremity surgery on activities and participation of children with cerebral palsy: a systematic review.Developmental medicine and child neurology · 2020Pooled it
- Hand Functions Following Prone-weight Bearing on Upper Limb with Active Elbow Extension Versus Modified Constraint Induced Movement Therapy in Children with Unilateral Cerebral Palsy - A Randomised Clinical Trial.NeuroRehabilitation · 2025Trial
- Feasibility trial of an early therapy in perinatal stroke (eTIPS).BMC neurology · 2018Trial
- REACH: study protocol of a randomised trial of rehabilitation very early in congenital hemiplegia.BMJ open · 2017Trial
- Creating an engaging brain computer interface, electrical stimulation therapy for children with hemiparesis: a pilot study.Journal of neuroengineering and rehabilitation · 2026Article
- Comparative Efficacy RCT of 3 Intensive Infant/Toddler Therapies for Unilateral Cerebral Palsy.Pediatrics open science · 2026Article
- A Holistic Approach Towards Evaluating Upper Limb Function in Children with Unilateral Cerebral Palsy: A Narrative Review of Clinical Tools and Promising Technologies for Comprehensive Assessment.Journal of clinical medicine · 2025Review
- Enhancing Grip Strength and Manual Dexterity in Unilateral Cerebral Palsy: A Randomized Trial of Mirror Visual Feedback vs. Modified Constraint-Induced Movement Therapy.Brain sciences · 2025Article
- Exploring the Link Between Motor Functions and the Relative Use of the More Affected Arm in Adults with Cerebral Palsy.Sensors (Basel, Switzerland) · 2025Article
- HEPChildren (Basel, Switzerland) · 2024Article
- The effect of a thumb web spacer splint on hand function in children with hemiplegic cerebral palsy.Journal of Taibah University Medical Sciences · 2023Article
- Pediatric Patients With Hemiplegia: A Systematic Review of a Randomized Controlled Trial.Cureus · 2023Review
- Predictive nomogram for soft robotic hand rehabilitation of patients with intracerebral hemorrhage.BMC neurology · 2022Article
- De novo and rare inherited copy-number variations in the hemiplegic form of cerebral palsy.Genetics in medicine : official journal of the American College of Medical Genetics · 2018Article
- Participatory design in the development of an early therapy intervention for perinatal stroke.BMC pediatrics · 2017Article
- The impact of Kinesio taping technique on children with cerebral palsy.Iranian journal of neurology · 2016Review
- Efficacy of neurodevelopmental treatment combined with the Nintendo(®) Wii in patients with cerebral palsy.Journal of physical therapy science · 2016Article
- Improving outcomes in cerebral palsy with early intervention: new translational approaches.Frontiers in neurology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Children with hemiplegic cerebral palsy often have marked hand involvement with excessive thumb adduction and flexion and limited active wrist extension from infancy. Post-lesional aberrant plasticity can lead to progressive abnormalities of the developing motor system. Disturbances of somatosensory and visual function and developmental disregard contribute to difficulties with hand use. Progressive soft tissue and bony changes may occur, leading to contractures, which further limit function in a vicious cycle. Early intervention might help to break this cycle, however, the precise nature and appropriateness of the intervention must be carefully considered. Traditional approaches to the hemiplegic upper limb include medications and botulinum toxin injections to manage abnormalities of tone, and surgical interventions. Therapist input, including provision of orthoses, remains a mainstay although many therapies have not been well evaluated. There has been a recent increase in interventions for the hemiplegic upper limb, mostly aimed outside the period of infancy. These include trials of constraint-induced movement therapy (CIMT) and bimanual therapy as well as the use of virtual reality and robot-assisted therapy. In future, non-invasive brain stimulation may be combined with therapy. Interventions under investigation in the infant age group include modified CIMT and action observation therapy. A further approach which may be suited to the infant with thumb-in-palm deformity, but which requires evaluation, is the use of elastic taping. Enhanced cutaneous feedback through mechanical stimulation to the skin provided by the tape during movement has been postulated to modulate ongoing muscle activity. If effective, this would represent a low-cost, safe, widely applicable early intervention.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.