ReviewFrontiers in neuroscience2014
Influence of sex and stress exposure across the lifespan on endophenotypes of depression: focus on behavior, glucocorticoids, and hippocampus.
Review in Frontiers in neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed.
- Sex Differences in Depression: Adult Cytogenesis as Potential Target for Precision Psychiatry.Cells · 2026Review
- Social Behavior and Neurogenesis.International journal of molecular sciences · 2026Review
- Association Between Metabolic Syndrome and Psychiatric Morbidity in a Nationwide Taiwanese Population Study.Nutrients · 2026Article
- Prenatal and neonatal housing conditions affect anxiety-like behavior in adulthood in rats and interact with brain-derived neurotrophic factor (BDNF) Val66Met to alter expression of BDNF and stress markers in the ventral hippocampus.Frontiers in molecular neuroscience · 2026Article
- Deletion ofFrontiers in cellular neuroscience · 2026Article
- Deletion ofbioRxiv : the preprint server for biology · 2025Article
- Corticosterone disrupts spatial working memory during retention testing when highly taxed, which positively correlates with depressive-like behavior in middle-aged, ovariectomized female rats.Hormones and behavior · 2024Article
- Septohippocampal cholinergic system at the intersection of stress and cognition: Current trends and translational implications.The European journal of neuroscience · 2024Review
- Early life adversity reduces affiliative behavior with a stressed cagemate and leads to sex-specific alterations in corticosterone responses in adult mice.Hormones and behavior · 2024Article
- Research progress on antidepressant effects and mechanisms of berberine.Frontiers in pharmacology · 2024Review
- Early life adversity ablates sex differences in active versus passive threat responding in mice.Stress (Amsterdam, Netherlands) · 2023Article
- Biomechanics of Traumatic Head and Neck Injuries on Women: A State-of-the-Art Review and Future Directions.Biology · 2023Review
- Gender Differences in the Correlations between Childhood Trauma, Schizotypy and Negative Emotions in Non-Clinical Individuals.Brain sciences · 2022Article
- Estrogen receptors mediate the antidepressant effects of aerobic exercise: A possible new mechanism.Frontiers in aging neuroscience · 2022Article
- Impact of the COVID-19 Pandemic on the Mental Health of Adolescent Students in Daegu, Korea.Journal of Korean medical science · 2021Article
- Escitalopram Targets Oxidative Stress, Caspase-3, BDNF and MeCP2 in the Hippocampus and Frontal Cortex of a Rat Model of Depression Induced by Chronic Unpredictable Mild Stress.International journal of molecular sciences · 2021Article
- miR-218 in Adolescence Predicts and Mediates Vulnerability to Stress.Biological psychiatry · 2021Article
- The influence of sex, gender, age, and ethnicity on psychosocial factors and substance use throughout phases of the COVID-19 pandemic.PloS one · 2021Article
- Relationship between depression and olfactory sensory function: a review.Chemical senses · 2021Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sex differences exist in vulnerability, symptoms, and treatment of many neuropsychiatric disorders. In this review, we discuss both preclinical and clinical research that investigates how sex influences depression endophenotypes at the behavioral, neuroendocrine, and neural levels across the lifespan. Chronic exposure to stress is a risk factor for depression and we discuss how stress during the prenatal, postnatal, and adolescent periods differentially affects males and females depending on the method of stress and metric examined. Given that the integrity of the hippocampus is compromised in depression, we specifically focus on sex differences in how hippocampal plasticity is affected by stress and depression across the lifespan. In addition, we examine how female physiology predisposes depression in adulthood, specifically in postpartum and perimenopausal periods. Finally, we discuss the underrepresentation of women in both preclinical and clinical research and how this limits our understanding of sex differences in vulnerability, presentation, and treatment of depression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.