ArticleThe Eurasian journal of medicine2011
Investigating biofilm production, coagulase and hemolytic activity in Candida species isolated from denture stomatitis patients.
Article in The Eurasian journal of medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 71 citations in OpenAlex.
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- Comparative analysis of enzymatic profiles and biofilm formation in clinical and environmental Candida kefyr isolates.Environmental microbiology reports · 2024Article
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- Biofilm Formation in Medically ImportantJournal of fungi (Basel, Switzerland) · 2023Review
- Biochemical typing and evaluation of pathogenicity in vulvovaginal isolates of Candida albicans complexBiomedica : revista del Instituto Nacional de Salud · 2023Article
- Detection of Virulence Factors fromArchives of Razi Institute · 2023Article
- A study of the association between virulence factors and antifungal susceptibility profile ofJournal of family medicine and primary care · 2023Article
- Antibiofilm Potential and Exoenzyme Inhibition byLife (Basel, Switzerland) · 2022Article
- Virulence Factors and Azole-Resistant Mechanism of Candida Tropicalis Isolated from Candidemia.Mycopathologia · 2021Article
- Non-Current medical mycology · 2021Article
- Virulence Factors and Antifungal Susceptibility Profile ofJournal of fungi (Basel, Switzerland) · 2021Article
- Clonal evolution ofJournal of oral microbiology · 2021Article
- Safety Evaluation of Yeasts With Probiotic Potential.Frontiers in nutrition · 2021Article
- Current Aspects in the Biology, Pathogeny, and Treatment ofInfection and drug resistance · 2020Review
- Evaluation of biofilm formation in the homozygous and heterozygous strains of vaginalCurrent medical mycology · 2019Article
- A Predominance of Clade 17Frontiers in microbiology · 2019Article
- How much do we know about hemolytic capability of pathogenic Candida species?Folia microbiologica · 2018Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveOral candidiasis, in the form of Candida-associated denture stomatitis, represents a common disease in a large percentage of denture wearers, and Candida albicans remains the most commonly isolated species. In this study, we aimed to evaluate biofilm production, coagulase and hemolytic activity of Candida species isolated from denture stomatitis patients. MATERIALS AND
methodsThis study included 70 patients (31 female, 39 male). Forty-eight of the patients were found to have a positive culture. A total of 48 Candida isolates representing five species, C. albicans (n=17), C. glabrata (n=10), C. krusei (n=9), C. kefyr (n=7) and C. parapsilosis (n=5), were tested. Their coagulase activities were evaluated by a classical tube coagulase test with rabbit plasma. A blood plate assay on 3% enriched sheep blood Sabouraud-dextrose agar (SDA) was used to determine their in vitro hemolytic activities. Biofilm production was determined by a visual tube method.
resultsTwenty-one Candida isolates exhibited coagulase activity, and the coagulase activities of the C. albicans (64.7%) isolates were higher than other species. C. albicans, C. glabrata, C. kefyr and C. krusei species demonstrated beta hemolysis. C. parapsilosis strains failed to demonstrate any hemolytic activities. Fifteen (88.0%) of the C. albicans strains were biofilm positive. Six (35.2%) of these strains were strongly positive, 8 (47.0%) C. albicans strains were moderately positive and 1 (5.8%) C. albicans strain was weakly positive. Sixteen (51.6%) of the non-albicans Candida strains were biofilm positive while 15 (48.3%) did not produce biofilms.
conclusionThe results of this present study indicate coagulase, hemolytic activity and biofilm production by Candida spp. isolated from patients with denture stomatitis. Investigations of these virulence factors might be helpful in gaining information about the possible virulence of oral Candida species related to denture stomatitis.
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