Evidence map›Paper›PMID 25609975›Full record

ReviewVascular health and risk management2015

Influence of immune activation and inflammatory response on cardiovascular risk associated with the human immunodeficiency virus.

Luis M Beltrán, Alfonso Rubio-Navarro, Juan Manuel Amaro-Villalobos, Jesús Egido, Juan García-Puig, Juan Antonio Moreno

Open access · goldAbstract readReview
In one paragraph

Review in Vascular health and risk management, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.

  1. Examining Depression as a Risk Factor for Cardiovascular Disease in People with HIV: A Systematic Review.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2023
    Pooled it
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  7. Article
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  11. Atherosclerosis in HIV Patients: What Do We Know so Far?International journal of molecular sciences · 2022
    Review
  12. Review
  13. Article
  14. Article
  15. HIV and Sexual Dysfunction in Men.Journal of clinical medicine · 2021
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Luis M BeltránMetabolic-Vascular Unit, Fundación IdiPAZ-Hospital Universitario La Paz, Madrid, Spain.
Alfonso Rubio-NavarroVascular, Renal, and Diabetes Research Lab, IIS-Fundación Jiménez Díaz, Madrid, Spain.
Juan Manuel Amaro-VillalobosVascular, Renal, and Diabetes Research Lab, IIS-Fundación Jiménez Díaz, Madrid, Spain.
Jesús EgidoVascular, Renal, and Diabetes Research Lab, IIS-Fundación Jiménez Díaz, Madrid, Spain ; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain ; Fundación Renal Iñigo Alvarez de Toledo-Instituto Reina Sofía de Investigaciones Nefrológicas (FRIAT-IRSIN), Madrid, Spain.
Juan García-PuigMetabolic-Vascular Unit, Fundación IdiPAZ-Hospital Universitario La Paz, Madrid, Spain.
Juan Antonio MorenoVascular, Renal, and Diabetes Research Lab, IIS-Fundación Jiménez Díaz, Madrid, Spain.
Hospital Universitario Fundación Jiménez Díaz · ESHospital Universitario La Paz · ESFundación Renal · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients infected with the human immunodeficiency virus (HIV) have an increased cardiovascular risk. Although initially this increased risk was attributed to metabolic alterations associated with antiretroviral treatment, in recent years, the attention has been focused on the HIV disease itself. Inflammation, immune system activation, and endothelial dysfunction facilitated by HIV infection have been identified as key factors in the development and progression of atherosclerosis. In this review, we describe the epidemiology and pathogenesis of cardiovascular disease in patients with HIV infection and summarize the latest knowledge on the relationship between traditional and novel inflammatory, immune activation, and endothelial dysfunction biomarkers on the cardiovascular risk associated with HIV infection.

Indexed as

AnimalsAnti-HIV AgentsBiomarkersCardiovascular DiseasesEndothelium, VascularHIVHIV InfectionsHost-Pathogen InteractionsHumansInflammationInflammation MediatorsPrognosisRisk AssessmentRisk FactorsAnti-HIV AgentsBiomarkersInflammation Mediatorsantiretroviral therapycardiovascular diseaseHIVimmune activationinflammation

Identifiers

PMID25609975
PMCPMC4293933
OpenAlexW2043807991

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.