ArticleNeuropsychiatric disease and treatment2015
Factors associated with the risk of relapse in schizophrenic patients after a response to electroconvulsive therapy: a retrospective study.
Article in Neuropsychiatric disease and treatment, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Relapse Following Electroconvulsive Therapy for Schizophrenia: A Systematic Review and Meta-analysis.Schizophrenia bulletin · 2026Pooled it
- Accuracy of machine learning methods in predicting prognosis of patients with psychotic spectrum disorders: a systematic review.BMJ open · 2025Pooled it
- Late to respond, but early to relapse - An abnormal course of electroconvulsive therapy in treatment-resistant schizophrenia during times of COVID-19.Psychiatry research case reports · 2022Article
- History of ECT in Schizophrenia: From Discovery to Current Use.Schizophrenia bulletin open · 2022Article
- Treatment Capacity and Clinical Outcomes for Patients With Schizophrenia Who Were Treated With Electroconvulsive Therapy: A Retrospective Cohort Study.Schizophrenia bulletin · 2021Article
- Clinical Effectiveness of Maintenance Electroconvulsive Therapy in Patients with Schizophrenia: A Retrospective Cohort Study.The journal of ECT · 2020Article
- Decreased serum levels of thrombospondin-1 in female depressed patients.Neuropsychopharmacology reports · 2020Article
- Shared preventive factors associated with relapse after a response to electroconvulsive therapy in four major psychiatric disorders.Psychiatry and clinical neurosciences · 2019Article
- Young patient with treatment-resistant schizophrenia drastically improved by combination of clozapine and maintenance electroconvulsive therapy: a case report.International medical case reports journal · 2019Article
- Combination of Electroconvulsive Therapy and Clozapine in Treatment-Resistant Schizophrenia.Psychiatry investigation · 2018Article
- Possible Association between Serum Matrix Metalloproteinase-9 (MMP-9) Levels and Relapse in Depressed Patients following Electroconvulsive Therapy (ECT).The international journal of neuropsychopharmacology · 2018Article
- Altered Serum Levels of Matrix Metalloproteinase-2, -9 in Response to Electroconvulsive Therapy for Mood Disorders.The international journal of neuropsychopharmacology · 2016Article
- Patients with schizophrenia or schizoaffective disorder who receive multiple electroconvulsive therapy sessions: characteristics, indications, and results.Neuropsychiatric disease and treatment · 2015Article
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Authors and funding
4 authors.
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Abstract
purposeElectroconvulsive therapy (ECT) is an effective treatment for depression and schizophrenia. However, there is a high rate of relapse after an initial response to ECT, even with antidepressant or antipsychotic maintenance therapy. This study was carried out to examine the factors that influence the risk of relapse in schizophrenic patients after a response to ECT. PATIENTS AND
methodsWe retrospectively reviewed the records of 43 patients with schizophrenia who received and responded to an acute ECT course. We analyzed the associated clinical variables and relapse after response to the acute ECT. Relapse was defined as a Clinical Global Impressions Improvement score ≥6 or a psychiatric rehospitalization.
resultsAll patients were treated with neuroleptic medication after the acute ECT course. The relapse-free rate of all 43 patients at 1 year was 57.3%, and the median relapse-free period was 21.5 months. Multivariate analysis showed that the number of ECT sessions was associated with a significant increase in the risk of relapse (hazard ratio: 1.159; P=0.033). Patients who were treated with adjunctive mood stabilizers as maintenance pharmacotherapy after the response to the acute ECT course were at a lower risk of relapse than were those treated without mood stabilizers (hazard ratio: 0.257; P=0.047).
conclusionOur study on the recurrence of schizophrenia after a response to an acute ECT course suggests that the number of ECT sessions might be related to the risk of relapse and that adjunctive mood stabilizers might be effective in preventing relapse.
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