ArticleInternational journal of nanomedicine2015
Oxidative stress and antibacterial properties of a graphene oxide-cystamine nanohybrid.
Article in International journal of nanomedicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 55 citations in OpenAlex.
- Advances in graphene-based 2D materials for tendon, nerve, bone/cartilage regeneration and biomedicine.iScience · 2024Review
- Stabilization of Graphene Oxide Dispersion in Plasma-like Isotonic Solution Containing Aggregating Concentrations of Bivalent Cations.Pharmaceutics · 2023Article
- Preventive effects of nano-graphene oxide against Parkinson's disease via reactive oxygen species scavenging and anti-inflammation.BMB reports · 2023Article
- The antimicrobial efficacy of graphene oxide, double antibiotic paste, and their combination against Enterococcus faecalis in the root canal treatment.BMC oral health · 2023Article
- The progress of research on the application of redox nanomaterials in disease therapy.Frontiers in chemistry · 2023Review
- Therapeutic Potential of Ursolic Acid in Cancer and Diabetic Neuropathy Diseases.International journal of molecular sciences · 2021Review
- Graphene Family Nanomaterials in Ocular Applications: Physicochemical Properties and Toxicity.Chemical research in toxicology · 2021Review
- Virus Inactivation in Water Using Laser-Induced Graphene Filters.Materials (Basel, Switzerland) · 2021Article
- Graphene-Wrapped Copper Nanoparticles: An Antimicrobial and Biocompatible Nanomaterial with Valuable Properties for Medical Uses.ACS omega · 2020Article
- Bio-Mediated Synthesis of Reduced Graphene Oxide Nanoparticles fromNanomaterials (Basel, Switzerland) · 2020Article
- Article
- Involvement of FAK/P38 Signaling Pathways in Mediating the Enhanced Osteogenesis Induced by Nano-Graphene Oxide Modification on Titanium Implant Surface.International journal of nanomedicine · 2020Article
- Synthesis of Graphene Oxide Using Atmospheric Plasma for Prospective Biological Applications.International journal of nanomedicine · 2020Article
- Medium-Dependent Antibacterial Properties and Bacterial Filtration Ability of Reduced Graphene Oxide.Nanomaterials (Basel, Switzerland) · 2019Article
- In Vitro Cytotoxicity and Morphological Assessments of GO-ZnO against the MCF-7 Cells: Determination of Singlet Oxygen by Chemical Trapping.Nanomaterials (Basel, Switzerland) · 2018Article
- Graphene Oxide-Based Nanocomposites Decorated with Silver Nanoparticles as an Antibacterial Agent.Nanoscale research letters · 2018Article
- Metabolomic insights of macrophage responses to graphene nanoplatelets: Role of scavenger receptor CD36.PloS one · 2018Article
- Redox-active nanomaterials for nanomedicine applications.Nanoscale · 2017Review
- Graphene Oxide-Coated Surface: Inhibition of Bacterial Biofilm Formation due to Specific Surface-Interface Interactions.ACS omega · 2017Article
- Study of antibacterial mechanism of graphene oxide using Raman spectroscopy.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress can damage proteins, DNA, and lipids, and is involved in the progression of many diseases. Damage to infected cells caused by oxidative stress is related to increased levels of reactive oxygen species, including hydrogen peroxide. During oxidative stress, hydrogen peroxide levels are often increased and catalase level decreased inside cells. This can lead to the death of skin and other cells. Hydrophobic low molecular weight compounds are useful in treating hemorrhagic conditions of the skin. To this end, cystamine has been successfully conjugated with graphene oxide (GO) as a drug carrier. The current study used the microdilution method to determine the minimum inhibitory concentrations of cystamine-conjugated GO against four types of pathogenic bacteria. Minimum inhibitory concentrations values were 1 μg/mL against Escherichia coli and Salmonella typhimurium, 6 μg/mL against Enterococcus faecalis, and 4 μg/mL against Bacillus subtilis. Toxicity of the conjugate against squamous cell carcinoma 7 cells was minimal at low concentrations, but increased in a dose-dependent manner. These results demonstrated that our protocol produced a cystamine-conjugated GO with low cytotoxicity, but strong reactive oxygen species effects and high antibacterial activity. This nanohybrid may be useful in the treatment of dermatological disorders. Moreover, this class of nanohybrid may have other biomedical applications due to their low cytotoxicity and high antibacterial activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.