ArticleInternational journal of nanomedicine2015
Effective near-infrared photodynamic therapy assisted by upconversion nanoparticles conjugated with photosensitizers.
Article in International journal of nanomedicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 177 citations in OpenAlex.
- Sodium alginate hydrogel loaded with upconversion nanoparticles and magnesium ions enhances bone regeneration and photodynamic tumor therapy.Frontiers in pharmacology · 2025Article
- Photoswitchable upconversion nanoparticles with excitation-dependent emission for programmed stepwise NIR phototherapy.iScience · 2023Article
- Highly-Efficient and Visible Light Photocatalytical Degradation of Organic Pollutants Using TiOMaterials (Basel, Switzerland) · 2022Article
- Near-infrared mediated orthogonal bioimaging and intracellular tracking of upconversion nanophotosensitizers.Mikrochimica acta · 2022Article
- Review
- Application of nanotechnology in the diagnosis and treatment of bladder cancer.Journal of nanobiotechnology · 2021Review
- Rationally designed upconversion nanoparticles for NIR light-controlled lysosomal escape and nucleus-based photodynamic therapy.Mikrochimica acta · 2021Article
- Photostable and Small YVONanomaterials (Basel, Switzerland) · 2021Article
- Hyperthermia by near infrared radiation induced immune cells activation and infiltration in breast tumor.Scientific reports · 2021Article
- Recent Advances in the Use of Iron-Gold Hybrid Nanoparticles for Biomedical Applications.Nanomaterials (Basel, Switzerland) · 2021Review
- What NIR photodynamic activation offers molecular targeted nanomedicines: Perspectives into the conundrum of tumor specificity and selectivity.Nano today · 2021Article
- Photodynamic Therapy-Current Limitations and Novel Approaches.Frontiers in chemistry · 2021Review
- Recent progress in the development of upconversion nanomaterials in bioimaging and disease treatment.Journal of nanobiotechnology · 2020Review
- Poisonous Caterpillar-Inspired Chitosan Nanofiber Enabling Dual Photothermal and Photodynamic Tumor Ablation.Pharmaceutics · 2019Article
- Chlorin e6-Coated Superparamagnetic Iron Oxide Nanoparticle (SPION) Nanoclusters as a Theranostic Agent for Dual-Mode Imaging and Photodynamic Therapy.Scientific reports · 2019Article
- Nanolipid Formulations of Benzoporphyrin Derivative: Exploring the Dependence of Nanoconstruct Photophysics and Photochemistry on Their Therapeutic Index in Ovarian Cancer Cells.Photochemistry and photobiology · 2019Article
- A Single-Step Surface Modification of Electrospun Silica Nanofibers Using a Silica Binding Protein Fused with an RGD Motif for Enhanced PC12 Cell Growth and Differentiation.Materials (Basel, Switzerland) · 2018Article
- Biomimetic polyurethane/TiOMaterials science & engineering. C, Materials for biological applications · 2018Article
- The Effect of Laminin Surface Modification of Electrospun Silica Nanofiber Substrate on Neuronal Tissue Engineering.Nanomaterials (Basel, Switzerland) · 2018Article
- An In Vitro Study of the Photodynamic Effectiveness of GO-Ag Nanocomposites against Human Breast Cancer Cells.Nanomaterials (Basel, Switzerland) · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A drug model photosensitizer-conjugated upconversion nanoparticles nanocomplex was explored for application in near-infrared photodynamic therapy. As near-infrared penetrates deeper into the tissue, the model is useful for the application of photodynamic therapy in deeper tissue. The nanocomplex that was synthesized had low polydispersity, and the upconversion nanoparticle was covalently conjugated with the photosensitizer. The robust bond could prevent the undesired premature release of photosensitizer and also enhance the singlet-oxygen generation. Singlet-oxygen generation rate from this nanocomplex was evaluated in solution. The photodynamic therapy effect was assessed with MCF-7 cells in two different methods, 3-(4,5-dimethylth-iazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and live/dead assay. The assay results showed that promising efficacy (>90%) can be achieved with a low concentration (50 μg mL(-1)) of this nanocomplex and mild dosage (7 mW cm(-2)) of near-infrared laser treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.