ArticleMedical journal, Armed Forces India2015
Heterogeneous vancomycin-intermediate among methicillin resistant Staphylococcus aureus.
Article in Medical journal, Armed Forces India, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- Global prevalence and distribution of vancomycin resistant, vancomycin intermediate and heterogeneously vancomycin intermediate Staphylococcus aureus clinical isolates: a systematic review and meta-analysis.Scientific reports · 2020Pooled it
- Pooled it
- Molecular and Clinical Features of Heterogeneous Vancomycin-IntermediateSultan Qaboos University medical journal · 2023Article
- Detection of heterogeneous vancomycin-intermediateThe Indian journal of medical research · 2019Article
- Antimicrobial susceptibility profile & resistance mechanisms of Global Antimicrobial Resistance Surveillance System (GLASS) priority pathogens from India.The Indian journal of medical research · 2019Review
- Article
- Pneumonia Caused by Methicillin-Resistant Staphylococcus aureus: Does Vancomycin Heteroresistance Matter?Antimicrobial agents and chemotherapy · 2016Article
- Staphylococcus aureus with reduced susceptibility to vancomycin in healthcare settings.Journal of preventive medicine and hygiene · 2014Review
- Recent pattern of antibiotic resistance inJournal of laboratory physiciansArticle
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHetero-resistance vancomycin intermediate Staphylococcus aureus (hVISA) is phenotype, which on in-vitro susceptibility test is vancomycin susceptible (VSSA) but has a minority population of vancomycin intermediate (VISA). hVISA is responsible for vancomycin treatment failure. Population Analysis Profile- Area under Curve (PAP-AUC) is a test for detection of hVISA; however, this test is unsuitable for clinical microbiology laboratory. Tests, such as Brain Heart Infusion Agar with 6 μg/ml vancomycin (BHIA6V), E test and Macromethod E Test (MET) are available; however reported to have variable results.
methods58 clinical isolates of Methicillin resistant S aureus (MRSA) having MIC of vancomycin more than 1 μg/ml by E test and agar dilution were analyzed by PAP-AUC, BHIA6V and MET.
resultThe prevalence of hVISA was 6.9%. hVISA isolates were having vancomycin E test MIC >2 μg/ml. Sensitivity of BHIA6V, MET and E test with MIC >2 μg/ml were 0.75, 0.67 and 1.0 respectively; however, positive predictive values (PPV) were 0.43, 0.4 and 0.27 respectively with PAP-AUC. PAP-AUC ratio correlated with MIC by E test and MET.
conclusionsThere is need for screening MRSA isolates showing in-vitro vancomycin susceptibility ≤2 μg/ml by agar dilution method for detection of hVISA. PAP-AUC test is unsuitable for routine laboratory testing. BHIA6V, MET and E test can be used for screening, however have low PPV.
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