ArticleDisease markers2014
High frequency of CD8 positive lymphocyte infiltration correlates with lack of lymph node involvement in early rectal cancer.
Article in Disease markers, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Plasma lipid levels are associated with the CD8+ T-cell infiltration and prognosis of patients with pancreatic cancer.Cancer medicine · 2023Article
- Immune Response and Immune Checkpoint Molecules in Patients with Rectal Cancer Undergoing Neoadjuvant Chemoradiotherapy: A Review.Current issues in molecular biology · 2023Review
- Tumor immune microenvironment in therapy-naive esophageal adenocarcinoma could predict the nodal status.Cancer medicine · 2023Article
- Tumor Microenvironment before and after Chemoradiation in Locally Advanced Rectal Cancer: Beyond PD-L1.Cancers · 2022Article
- Article
- Prognostic significance of CD8+ T-cells density in stage III colorectal cancer depends on SDF-1 expression.Scientific reports · 2021Article
- Article
- Toll-Like Receptor 3 as a Recurrence Risk Factor and a Potential Molecular Therapeutic Target in Colorectal Cancer.Clinical and experimental gastroenterology · 2020Article
- Over-expression of Nav1.6 channels is associated with lymph node metastases in colorectal cancer.World journal of surgical oncology · 2019Article
- Tumor Infiltrating Lymphocytes and Macrophages Improve Survival in Microsatellite Unstable Colorectal Cancer.Scientific reports · 2019Article
- Cytolytic Activity Score to Assess Anticancer Immunity in Colorectal Cancer.Annals of surgical oncology · 2018Article
- Analysis of tumor-infiltrating gamma delta T cells in rectal cancer.World journal of gastroenterology · 2016Article
- The immune response in cancer: from immunology to pathology to immunotherapy.Virchows Archiv : an international journal of pathology · 2015Review
Corrections and comments
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Authors and funding
19 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsA trend towards local excision of early rectal cancers has prompted us to investigate if immunoprofiling might help in predicting lymph node involvement in this subgroup.
methodsA tissue microarray of 126 biopsies of early rectal cancer (T1 and T2) was stained for several immunomarkers of the innate and the adaptive immune response. Patients' survival and nodal status were analyzed and correlated with infiltration of the different immune cells.
resultsOf all tested markers, only CD8 (P = 0.005) and TIA-1 (P = 0.05) were significantly more frequently detectable in early rectal cancer biopsies of node negative as compared to node positive patients. Although these two immunomarkers did not display prognostic effect "per se," CD8+ and, marginally, TIA-1 T cell infiltration could predict nodal involvement in univariate logistic regression analysis (OR 0.994; 95% CI 0.992-0.996; P = 0.009 and OR 0.988; 95% CI 0.984-0.994; P = 0.05, resp.). An algorithm significantly predicting the nodal status in early rectal cancer based on CD8 together with vascular invasion and tumor border configuration could be calculated (P < 0.00001).
conclusionOur data indicate that in early rectal cancers absence of CD8+ T-cell infiltration helps in predicting patients' nodal involvement.
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