Evidence map›Paper›PMID 25609766›Full record

ArticleNeurology2015

Relationships between quantitative spinal cord MRI and retinal layers in multiple sclerosis.

Jiwon Oh, Elias S Sotirchos, Shiv Saidha, Anna Whetstone, Min Chen, Scott D Newsome, Kathy Zackowski, Laura J Balcer, Elliot Frohman, Jerry Prince and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Jiwon OhFrom the Departments of Neurology (J.O., E.S.S., S.S., A.W., S.D.N., K.Z., D.S.R., P.A.C.), Electrical and Computer Engineering (M.C., J.P.), Computer Science (J.P.), Physical Medicine and Rehabilitation (K.Z.), Biostatistics (M.C., M.D.-W., D.S.R.), and Radiology and Radiological Science (D.S.R.), Johns Hopkins University, Baltimore, MD; Division of Neurology (J.O.), Department of Medicine, St. Michael's Hospital, University of Toronto, Canada; Motion Analysis Laboratory (K.Z.), Kennedy Krieger Institute, Baltimore, MD; Department of Neurology (L.J.B.), University of Pennsylvania School of Medicine, Philadelphia; Departments of Neurology and Ophthalmology (E.F.), University of Texas Southwestern Medical Center at Dallas; and Translational Neuroradiology Unit (D.S.R.), National Institute of Neurological Disorders and Stroke, Bethesda, MD. pcalabr1@jhmi.edu joh20@jhu.edu.
Elias S SotirchosFrom the Departments of Neurology (J.O., E.S.S., S.S., A.W., S.D.N., K.Z., D.S.R., P.A.C.), Electrical and Computer Engineering (M.C., J.P.), Computer Science (J.P.), Physical Medicine and Rehabilitation (K.Z.), Biostatistics (M.C., M.D.-W., D.S.R.), and Radiology and Radiological Science (D.S.R.), Johns Hopkins University, Baltimore, MD; Division of Neurology (J.O.), Department of Medicine, St. Michael's Hospital, University of Toronto, Canada; Motion Analysis Laboratory (K.Z.), Kennedy Krieger Institute, Baltimore, MD; Department of Neurology (L.J.B.), University of Pennsylvania School of Medicine, Philadelphia; Departments of Neurology and Ophthalmology (E.F.), University of Texas Southwestern Medical Center at Dallas; and Translational Neuroradiology Unit (D.S.R.), National Institute of Neurological Disorders and Stroke, Bethesda, MD.
Shiv SaidhaFrom the Departments of Neurology (J.O., E.S.S., S.S., A.W., S.D.N., K.Z., D.S.R., P.A.C.), Electrical and Computer Engineering (M.C., J.P.), Computer Science (J.P.), Physical Medicine and Rehabilitation (K.Z.), Biostatistics (M.C., M.D.-W., D.S.R.), and Radiology and Radiological Science (D.S.R.), Johns Hopkins University, Baltimore, MD; Division of Neurology (J.O.), Department of Medicine, St. Michael's Hospital, University of Toronto, Canada; Motion Analysis Laboratory (K.Z.), Kennedy Krieger Institute, Baltimore, MD; Department of Neurology (L.J.B.), University of Pennsylvania School of Medicine, Philadelphia; Departments of Neurology and Ophthalmology (E.F.), University of Texas Southwestern Medical Center at Dallas; and Translational Neuroradiology Unit (D.S.R.), National Institute of Neurological Disorders and Stroke, Bethesda, MD.
Anna WhetstoneFrom the Departments of Neurology (J.O., E.S.S., S.S., A.W., S.D.N., K.Z., D.S.R., P.A.C.), Electrical and Computer Engineering (M.C., J.P.), Computer Science (J.P.), Physical Medicine and Rehabilitation (K.Z.), Biostatistics (M.C., M.D.-W., D.S.R.), and Radiology and Radiological Science (D.S.R.), Johns Hopkins University, Baltimore, MD; Division of Neurology (J.O.), Department of Medicine, St. Michael's Hospital, University of Toronto, Canada; Motion Analysis Laboratory (K.Z.), Kennedy Krieger Institute, Baltimore, MD; Department of Neurology (L.J.B.), University of Pennsylvania School of Medicine, Philadelphia; Departments of Neurology and Ophthalmology (E.F.), University of Texas Southwestern Medical Center at Dallas; and Translational Neuroradiology Unit (D.S.R.), National Institute of Neurological Disorders and Stroke, Bethesda, MD.
Min ChenFrom the Departments of Neurology (J.O., E.S.S., S.S., A.W., S.D.N., K.Z., D.S.R., P.A.C.), Electrical and Computer Engineering (M.C., J.P.), Computer Science (J.P.), Physical Medicine and Rehabilitation (K.Z.), Biostatistics (M.C., M.D.-W., D.S.R.), and Radiology and Radiological Science (D.S.R.), Johns Hopkins University, Baltimore, MD; Division of Neurology (J.O.), Department of Medicine, St. Michael's Hospital, University of Toronto, Canada; Motion Analysis Laboratory (K.Z.), Kennedy Krieger Institute, Baltimore, MD; Department of Neurology (L.J.B.), University of Pennsylvania School of Medicine, Philadelphia; Departments of Neurology and Ophthalmology (E.F.), University of Texas Southwestern Medical Center at Dallas; and Translational Neuroradiology Unit (D.S.R.), National Institute of Neurological Disorders and Stroke, Bethesda, MD.
Scott D NewsomeFrom the Departments of Neurology (J.O., E.S.S., S.S., A.W., S.D.N., K.Z., D.S.R., P.A.C.), Electrical and Computer Engineering (M.C., J.P.), Computer Science (J.P.), Physical Medicine and Rehabilitation (K.Z.), Biostatistics (M.C., M.D.-W., D.S.R.), and Radiology and Radiological Science (D.S.R.), Johns Hopkins University, Baltimore, MD; Division of Neurology (J.O.), Department of Medicine, St. Michael's Hospital, University of Toronto, Canada; Motion Analysis Laboratory (K.Z.), Kennedy Krieger Institute, Baltimore, MD; Department of Neurology (L.J.B.), University of Pennsylvania School of Medicine, Philadelphia; Departments of Neurology and Ophthalmology (E.F.), University of Texas Southwestern Medical Center at Dallas; and Translational Neuroradiology Unit (D.S.R.), National Institute of Neurological Disorders and Stroke, Bethesda, MD.
Kathy ZackowskiFrom the Departments of Neurology (J.O., E.S.S., S.S., A.W., S.D.N., K.Z., D.S.R., P.A.C.), Electrical and Computer Engineering (M.C., J.P.), Computer Science (J.P.), Physical Medicine and Rehabilitation (K.Z.), Biostatistics (M.C., M.D.-W., D.S.R.), and Radiology and Radiological Science (D.S.R.), Johns Hopkins University, Baltimore, MD; Division of Neurology (J.O.), Department of Medicine, St. Michael's Hospital, University of Toronto, Canada; Motion Analysis Laboratory (K.Z.), Kennedy Krieger Institute, Baltimore, MD; Department of Neurology (L.J.B.), University of Pennsylvania School of Medicine, Philadelphia; Departments of Neurology and Ophthalmology (E.F.), University of Texas Southwestern Medical Center at Dallas; and Translational Neuroradiology Unit (D.S.R.), National Institute of Neurological Disorders and Stroke, Bethesda, MD.
Laura J BalcerFrom the Departments of Neurology (J.O., E.S.S., S.S., A.W., S.D.N., K.Z., D.S.R., P.A.C.), Electrical and Computer Engineering (M.C., J.P.), Computer Science (J.P.), Physical Medicine and Rehabilitation (K.Z.), Biostatistics (M.C., M.D.-W., D.S.R.), and Radiology and Radiological Science (D.S.R.), Johns Hopkins University, Baltimore, MD; Division of Neurology (J.O.), Department of Medicine, St. Michael's Hospital, University of Toronto, Canada; Motion Analysis Laboratory (K.Z.), Kennedy Krieger Institute, Baltimore, MD; Department of Neurology (L.J.B.), University of Pennsylvania School of Medicine, Philadelphia; Departments of Neurology and Ophthalmology (E.F.), University of Texas Southwestern Medical Center at Dallas; and Translational Neuroradiology Unit (D.S.R.), National Institute of Neurological Disorders and Stroke, Bethesda, MD.
Elliot FrohmanFrom the Departments of Neurology (J.O., E.S.S., S.S., A.W., S.D.N., K.Z., D.S.R., P.A.C.), Electrical and Computer Engineering (M.C., J.P.), Computer Science (J.P.), Physical Medicine and Rehabilitation (K.Z.), Biostatistics (M.C., M.D.-W., D.S.R.), and Radiology and Radiological Science (D.S.R.), Johns Hopkins University, Baltimore, MD; Division of Neurology (J.O.), Department of Medicine, St. Michael's Hospital, University of Toronto, Canada; Motion Analysis Laboratory (K.Z.), Kennedy Krieger Institute, Baltimore, MD; Department of Neurology (L.J.B.), University of Pennsylvania School of Medicine, Philadelphia; Departments of Neurology and Ophthalmology (E.F.), University of Texas Southwestern Medical Center at Dallas; and Translational Neuroradiology Unit (D.S.R.), National Institute of Neurological Disorders and Stroke, Bethesda, MD.
Jerry PrinceFrom the Departments of Neurology (J.O., E.S.S., S.S., A.W., S.D.N., K.Z., D.S.R., P.A.C.), Electrical and Computer Engineering (M.C., J.P.), Computer Science (J.P.), Physical Medicine and Rehabilitation (K.Z.), Biostatistics (M.C., M.D.-W., D.S.R.), and Radiology and Radiological Science (D.S.R.), Johns Hopkins University, Baltimore, MD; Division of Neurology (J.O.), Department of Medicine, St. Michael's Hospital, University of Toronto, Canada; Motion Analysis Laboratory (K.Z.), Kennedy Krieger Institute, Baltimore, MD; Department of Neurology (L.J.B.), University of Pennsylvania School of Medicine, Philadelphia; Departments of Neurology and Ophthalmology (E.F.), University of Texas Southwestern Medical Center at Dallas; and Translational Neuroradiology Unit (D.S.R.), National Institute of Neurological Disorders and Stroke, Bethesda, MD.
Marie Diener-WestFrom the Departments of Neurology (J.O., E.S.S., S.S., A.W., S.D.N., K.Z., D.S.R., P.A.C.), Electrical and Computer Engineering (M.C., J.P.), Computer Science (J.P.), Physical Medicine and Rehabilitation (K.Z.), Biostatistics (M.C., M.D.-W., D.S.R.), and Radiology and Radiological Science (D.S.R.), Johns Hopkins University, Baltimore, MD; Division of Neurology (J.O.), Department of Medicine, St. Michael's Hospital, University of Toronto, Canada; Motion Analysis Laboratory (K.Z.), Kennedy Krieger Institute, Baltimore, MD; Department of Neurology (L.J.B.), University of Pennsylvania School of Medicine, Philadelphia; Departments of Neurology and Ophthalmology (E.F.), University of Texas Southwestern Medical Center at Dallas; and Translational Neuroradiology Unit (D.S.R.), National Institute of Neurological Disorders and Stroke, Bethesda, MD.
Daniel S ReichFrom the Departments of Neurology (J.O., E.S.S., S.S., A.W., S.D.N., K.Z., D.S.R., P.A.C.), Electrical and Computer Engineering (M.C., J.P.), Computer Science (J.P.), Physical Medicine and Rehabilitation (K.Z.), Biostatistics (M.C., M.D.-W., D.S.R.), and Radiology and Radiological Science (D.S.R.), Johns Hopkins University, Baltimore, MD; Division of Neurology (J.O.), Department of Medicine, St. Michael's Hospital, University of Toronto, Canada; Motion Analysis Laboratory (K.Z.), Kennedy Krieger Institute, Baltimore, MD; Department of Neurology (L.J.B.), University of Pennsylvania School of Medicine, Philadelphia; Departments of Neurology and Ophthalmology (E.F.), University of Texas Southwestern Medical Center at Dallas; and Translational Neuroradiology Unit (D.S.R.), National Institute of Neurological Disorders and Stroke, Bethesda, MD.
Peter A CalabresiFrom the Departments of Neurology (J.O., E.S.S., S.S., A.W., S.D.N., K.Z., D.S.R., P.A.C.), Electrical and Computer Engineering (M.C., J.P.), Computer Science (J.P.), Physical Medicine and Rehabilitation (K.Z.), Biostatistics (M.C., M.D.-W., D.S.R.), and Radiology and Radiological Science (D.S.R.), Johns Hopkins University, Baltimore, MD; Division of Neurology (J.O.), Department of Medicine, St. Michael's Hospital, University of Toronto, Canada; Motion Analysis Laboratory (K.Z.), Kennedy Krieger Institute, Baltimore, MD; Department of Neurology (L.J.B.), University of Pennsylvania School of Medicine, Philadelphia; Departments of Neurology and Ophthalmology (E.F.), University of Texas Southwestern Medical Center at Dallas; and Translational Neuroradiology Unit (D.S.R.), National Institute of Neurological Disorders and Stroke, Bethesda, MD. pcalabr1@jhmi.edu joh20@jhu.edu.
The University of Texas Southwestern Medical Center · USUniversity of Pennsylvania · USSt. Michael's Hospital · CAKennedy Krieger Institute · USUniversity of Toronto · CA

Funding

Multimodal MRI in Multiple SclerosisZIANS003119 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI REICH, DANIEL · 2010 to 2025
$53.4M
Imaging Neurodegeneration in Multiple SclerosisR01NS082347 · NINDS · JOHNS HOPKINS UNIVERSITY · PI PETER A CALABRESI, Shiv Saidha · 2013 to 2026
$7.0M
MECHANISMS OF LOCOMOTOR RECOVERY IN MULTIPLE SCLEROSISK01HD049476 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI ZACKOWSKI, KATHLEEN M. · 2006 to 2010
$499k
Intramural NIH HHSNICHD NIH HHS K01 HD049476NINDS NIH HHS NIH R01NS08234NINDS NIH HHS R01 NS082347PHS HHS K01 HDO49476
6 · The paper itself

Abstract

objectiveTo assess relationships between spinal cord MRI (SC-MRI) and retinal measures, and to evaluate whether these measures independently relate to clinical disability in multiple sclerosis (MS).

methodsOne hundred two patients with MS and 11 healthy controls underwent 3-tesla brain and cervical SC-MRI, which included standard T1- and T2-based sequences and diffusion-tensor and magnetization-transfer imaging, and optical coherence tomography with automated segmentation. Clinical assessments included visual acuity (VA), Expanded Disability Status Scale, MS functional composite, vibration sensation threshold, and hip-flexion strength. Regions of interest circumscribing SC cross-sections at C3-4 were used to obtain cross-sectional area (CSA), fractional anisotropy (FA), perpendicular diffusivity (λ⊥), and magnetization transfer ratio. Multivariable regression assessed group differences and SC, retinal, and clinical relationships.

resultsIn MS, there were correlations between SC-CSA, SC-FA, SC-λ⊥, and peripapillary retinal nerve fiber layer (pRNFL) (p = 0.01, p = 0.002, p = 0.001, respectively) after adjusting for age, sex, prior optic neuritis, and brain atrophy. In multivariable clinical models, when SC-CSA, pRNFL, and brain atrophy were included simultaneously, SC-CSA and pRNFL retained independent relationships with low-contrast VA (p = 0.04, p = 0.002, respectively), high-contrast VA (p = 0.06, p = 0.008), and vibration sensation threshold (p = 0.01, p = 0.05). SC-CSA alone retained independent relationships with Expanded Disability Status Scale (p = 0.001), hip-flexion strength (p = 0.001), and MS functional composite (p = 0.004).

conclusionsIn this cross-sectional study of patients with MS, correlations exist between SC-MRI and retinal layers, and both exhibit independent relationships with clinical dysfunction. These findings suggest that the SC and optic nerve reflect ongoing global pathologic processes that supplement measures of whole-brain atrophy, highlighting the importance of combining measures from unique compartments to facilitate a thorough examination of regional and global disease processes that contribute to clinical disability in MS.

Indexed as

AdultBrainCervical VertebraeCross-Sectional StudiesDiffusion Tensor ImagingFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedMultiple SclerosisPattern Recognition, AutomatedRetinaSpinal CordTomography, Optical Coherence

Identifiers

PMID25609766
PMCPMC4336102
OpenAlexW2140155096

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.