ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Interplay of inhibition and excitation shapes a premotor neural sequence.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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Who cites it
67 citing papers in PubMed, 116 citations in OpenAlex.
- Article
- Motor neurons organize Drosophila feeding sequences via a disinhibitory cascade.Nature neuroscience · 2026Article
- Article
- Post-synaptic facilitation and network dynamics underlying stimulus-specific combination sensitivity.iScience · 2026Article
- Article
- Temperature robustness of the timing network within songbird premotor nucleus HVC.Journal of computational neuroscience · 2026Article
- Social familiarity strengthens neural and vocal responses to conspecific calls in zebra finches.PLoS computational biology · 2026Article
- Article
- Disinhibition of a recurrent attractor gates a persistent goal signal for navigation.bioRxiv : the preprint server for biology · 2025Article
- Mitochondria delay action potential propagation.Communications biology · 2025Article
- Bursts from the past: Intrinsic properties link a network model to zebra finch song.bioRxiv : the preprint server for biology · 2025Article
- Article
- Differential behavioral engagement of inhibitory interneuron subtypes in the zebra finch brain.Neuron · 2025Article
- Perineuronal nets in motor circuitry regulate the performance of learned vocalizations in songbirds.Communications biology · 2025Article
- Variable and slow-paced neural dynamics in HVC underlie plastic song production in juvenile zebra finches.BMC neuroscience · 2024Article
- Millisecond-scale motor coding precedes sensorimotor learning in songbirds.bioRxiv : the preprint server for biology · 2024Article
- Discovering plasticity rules that organize and maintain neural circuits.bioRxiv : the preprint server for biology · 2024Article
- Disinhibition enables vocal repertoire expansion after a critical period.Nature communications · 2024Article
- Resilience of A Learned Motor Behavior After Chronic Disruption of Inhibitory Circuits.bioRxiv : the preprint server for biology · 2024Article
- Neuronal activation sequences in lateral prefrontal cortex encode visuospatial working memory during virtual navigation.Nature communications · 2024Article
7 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In the zebra finch, singing behavior is driven by a sequence of bursts within premotor neurons located in the forebrain nucleus HVC (proper name). In addition to these excitatory projection neurons, HVC also contains inhibitory interneurons with a role in premotor patterning that is unclear. Here, we used a range of electrophysiological and behavioral observations to test previously described models suggesting discrete functional roles for inhibitory interneurons in song production. We show that single HVC premotor neuron bursts are sufficient to drive structured activity within the interneuron network because of pervasive and facilitating synaptic connections. We characterize interneuron activity during singing and describe reliable pauses in the firing of those neurons. We then demonstrate that these gaps in inhibition are likely to be necessary for driving normal bursting behavior in HVC premotor neurons and suggest that structured inhibition and excitation may be a general mechanism enabling sequence generation in other circuits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.