ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Desynchronization of fast-spiking interneurons reduces β-band oscillations and imbalance in firing in the dopamine-depleted striatum.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 47 citations in OpenAlex.
- Reconciling contradictory models of subthalamic nucleus contributions to basal ganglia beta oscillations.PLoS computational biology · 2026Article
- In silico model of basal ganglia deep brain stimulation in Parkinson's disease captures range of effective parameters for pathological beta power suppression.PLoS computational biology · 2026Article
- Remodeling of Perineuronal Nets in the Striato-Cortical Axis in L-DOPA-Induced Dyskinesia Rat Model.International journal of molecular sciences · 2025Article
- Computational model for control of hand movement in Parkinson's disease using deep brain stimulation.Experimental brain research · 2025Article
- Ginsenoside Rg1 ameliorates stress-exacerbated Parkinson's disease in mice by eliminating RTP801 and α-synuclein autophagic degradation obstacle.Acta pharmacologica Sinica · 2025Article
- Altered Thalamocortical Signaling in a Mouse Model of Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Dopamine depletion leads to pathological synchronization of distinct basal ganglia loops in the beta band.PLoS computational biology · 2023Article
- Altered functional connectivity associated with striatal dopamine depletion in Parkinson's disease.Cerebral cortex communications · 2023Article
- The nonsynaptic plasticity in Parkinson's disease: Insights from an animal model.Clinics (Sao Paulo, Brazil) · 2023Article
- Deep brain stimulation in the subthalamic nucleus for Parkinson's disease can restore dynamics of striatal networks.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Basal ganglia activation localized in MEG using a reward task.Neuroimage. Reports · 2021Article
- The microcircuits of striatum in silico.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Striatal network modeling in Huntington's Disease.PLoS computational biology · 2020Article
- Temporal evolution of beta bursts in the parkinsonian cortical and basal ganglia network.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Exploring the role of striatal D1 and D2 medium spiny neurons in action selection using a virtual robotic framework.The European journal of neuroscience · 2019Article
- Insights into Parkinson's disease from computational models of the basal ganglia.Journal of neurology, neurosurgery, and psychiatry · 2018Review
- Propagation of beta/gamma rhythms in the cortico-basal ganglia circuits of the parkinsonian rat.Journal of neurophysiology · 2018Article
- Parameter Optimization Using Covariance Matrix Adaptation-Evolutionary Strategy (CMA-ES), an Approach to Investigate Differences in Channel Properties Between Neuron Subtypes.Frontiers in neuroinformatics · 2018Article
- A Population of Indirect Pathway Striatal Projection Neurons Is Selectively Entrained to Parkinsonian Beta Oscillations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- A Low-Correlation Resting State of the Striatum during Cortical Avalanches and Its Role in Movement Suppression.PLoS biology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Oscillations in the β-band (8-30 Hz) that emerge in the output nuclei of the basal ganglia during Parkinson's disease, along with an imbalanced activation of the direct and indirect pathways, have been linked to the hypokinetic motor output associated with the disease. Although dopamine depletion causes a change in cellular and network properties in the striatum, it is unclear whether abnormal activity measured in the globus pallidus and substantia nigra pars reticulata is caused by abnormal striatal activity. Here we use a computational network model of medium spiny neurons (MSNs)-fast-spiking interneurons (FSIs), based on data from several mammalian species, and find that robust β-band oscillations and imbalanced firing emerge from implementation of changes to cellular and circuit properties caused by dopamine depletion. These changes include a reduction in connections between MSNs, a doubling of FSI inhibition to D2 MSNs, an increase in D2 MSN dendritic excitability, and a reduction in D2 MSN somatic excitability. The model reveals that the reduced decorrelation between MSNs attributable to weakened lateral inhibition enables the strong influence of synchronous FSIs on MSN firing and oscillations. Weakened lateral inhibition also produces an increased sensitivity of MSN output to cortical correlation, a condition relevant to the parkinsonian striatum. The oscillations of FSIs, in turn, are strongly modulated by fast electrical transmission between FSIs through gap junctions. These results suggest that pharmaceuticals that desynchronize FSI activity may provide a novel treatment for the enhanced β-band oscillations, imbalanced firing, and motor dysfunction in Parkinson's disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.