Evidence map›Paper›PMID 25609597›Full record

ArticleThe international journal of neuropsychopharmacology2014

Depressive-like behavior is paired to monoaminergic alteration in a murine model of Alzheimer's disease.

Adele Romano, Lorenzo Pace, Bianca Tempesta, Angelo Michele Lavecchia, Teresa Macheda, Gaurav Bedse, Antonio Petrella, Carlo Cifani, Gaetano Serviddio, Gianluigi Vendemiale and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of neuropsychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 85 citations in OpenAlex.

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  7. Experimental laboratory models as tools for understanding modifiable dementia risk.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Adele RomanoDepartment of Physiology and Pharmacology, Sapienza University of Rome, Italy (Drs Romano, Tempesta, Lavecchia, Bedse, and Gaetani); Department of Clinical and Experimental Medicine, University of Foggia, Italy (Drs Pace, Macheda, and Cassano); Puglia and Basilicata Experimental Zooprophylactic Institute, Foggia, Italy (Dr Petrella); School of Pharmacy, Pharmacology Unit, University of Camerino, Italy (Dr Cifani); Department of Medical and Surgical Sciences, University of Foggia, Italy (Drs Serviddio and Vendemiale).
Lorenzo PaceDepartment of Physiology and Pharmacology, Sapienza University of Rome, Italy (Drs Romano, Tempesta, Lavecchia, Bedse, and Gaetani); Department of Clinical and Experimental Medicine, University of Foggia, Italy (Drs Pace, Macheda, and Cassano); Puglia and Basilicata Experimental Zooprophylactic Institute, Foggia, Italy (Dr Petrella); School of Pharmacy, Pharmacology Unit, University of Camerino, Italy (Dr Cifani); Department of Medical and Surgical Sciences, University of Foggia, Italy (Drs Serviddio and Vendemiale).
Bianca TempestaDepartment of Physiology and Pharmacology, Sapienza University of Rome, Italy (Drs Romano, Tempesta, Lavecchia, Bedse, and Gaetani); Department of Clinical and Experimental Medicine, University of Foggia, Italy (Drs Pace, Macheda, and Cassano); Puglia and Basilicata Experimental Zooprophylactic Institute, Foggia, Italy (Dr Petrella); School of Pharmacy, Pharmacology Unit, University of Camerino, Italy (Dr Cifani); Department of Medical and Surgical Sciences, University of Foggia, Italy (Drs Serviddio and Vendemiale).
Angelo Michele LavecchiaDepartment of Physiology and Pharmacology, Sapienza University of Rome, Italy (Drs Romano, Tempesta, Lavecchia, Bedse, and Gaetani); Department of Clinical and Experimental Medicine, University of Foggia, Italy (Drs Pace, Macheda, and Cassano); Puglia and Basilicata Experimental Zooprophylactic Institute, Foggia, Italy (Dr Petrella); School of Pharmacy, Pharmacology Unit, University of Camerino, Italy (Dr Cifani); Department of Medical and Surgical Sciences, University of Foggia, Italy (Drs Serviddio and Vendemiale).
Teresa MachedaDepartment of Physiology and Pharmacology, Sapienza University of Rome, Italy (Drs Romano, Tempesta, Lavecchia, Bedse, and Gaetani); Department of Clinical and Experimental Medicine, University of Foggia, Italy (Drs Pace, Macheda, and Cassano); Puglia and Basilicata Experimental Zooprophylactic Institute, Foggia, Italy (Dr Petrella); School of Pharmacy, Pharmacology Unit, University of Camerino, Italy (Dr Cifani); Department of Medical and Surgical Sciences, University of Foggia, Italy (Drs Serviddio and Vendemiale).
Gaurav BedseDepartment of Physiology and Pharmacology, Sapienza University of Rome, Italy (Drs Romano, Tempesta, Lavecchia, Bedse, and Gaetani); Department of Clinical and Experimental Medicine, University of Foggia, Italy (Drs Pace, Macheda, and Cassano); Puglia and Basilicata Experimental Zooprophylactic Institute, Foggia, Italy (Dr Petrella); School of Pharmacy, Pharmacology Unit, University of Camerino, Italy (Dr Cifani); Department of Medical and Surgical Sciences, University of Foggia, Italy (Drs Serviddio and Vendemiale).
Antonio PetrellaDepartment of Physiology and Pharmacology, Sapienza University of Rome, Italy (Drs Romano, Tempesta, Lavecchia, Bedse, and Gaetani); Department of Clinical and Experimental Medicine, University of Foggia, Italy (Drs Pace, Macheda, and Cassano); Puglia and Basilicata Experimental Zooprophylactic Institute, Foggia, Italy (Dr Petrella); School of Pharmacy, Pharmacology Unit, University of Camerino, Italy (Dr Cifani); Department of Medical and Surgical Sciences, University of Foggia, Italy (Drs Serviddio and Vendemiale).
Carlo CifaniDepartment of Physiology and Pharmacology, Sapienza University of Rome, Italy (Drs Romano, Tempesta, Lavecchia, Bedse, and Gaetani); Department of Clinical and Experimental Medicine, University of Foggia, Italy (Drs Pace, Macheda, and Cassano); Puglia and Basilicata Experimental Zooprophylactic Institute, Foggia, Italy (Dr Petrella); School of Pharmacy, Pharmacology Unit, University of Camerino, Italy (Dr Cifani); Department of Medical and Surgical Sciences, University of Foggia, Italy (Drs Serviddio and Vendemiale).
Gaetano ServiddioDepartment of Physiology and Pharmacology, Sapienza University of Rome, Italy (Drs Romano, Tempesta, Lavecchia, Bedse, and Gaetani); Department of Clinical and Experimental Medicine, University of Foggia, Italy (Drs Pace, Macheda, and Cassano); Puglia and Basilicata Experimental Zooprophylactic Institute, Foggia, Italy (Dr Petrella); School of Pharmacy, Pharmacology Unit, University of Camerino, Italy (Dr Cifani); Department of Medical and Surgical Sciences, University of Foggia, Italy (Drs Serviddio and Vendemiale).
Gianluigi VendemialeDepartment of Physiology and Pharmacology, Sapienza University of Rome, Italy (Drs Romano, Tempesta, Lavecchia, Bedse, and Gaetani); Department of Clinical and Experimental Medicine, University of Foggia, Italy (Drs Pace, Macheda, and Cassano); Puglia and Basilicata Experimental Zooprophylactic Institute, Foggia, Italy (Dr Petrella); School of Pharmacy, Pharmacology Unit, University of Camerino, Italy (Dr Cifani); Department of Medical and Surgical Sciences, University of Foggia, Italy (Drs Serviddio and Vendemiale).
Silvana GaetaniDepartment of Physiology and Pharmacology, Sapienza University of Rome, Italy (Drs Romano, Tempesta, Lavecchia, Bedse, and Gaetani); Department of Clinical and Experimental Medicine, University of Foggia, Italy (Drs Pace, Macheda, and Cassano); Puglia and Basilicata Experimental Zooprophylactic Institute, Foggia, Italy (Dr Petrella); School of Pharmacy, Pharmacology Unit, University of Camerino, Italy (Dr Cifani); Department of Medical and Surgical Sciences, University of Foggia, Italy (Drs Serviddio and Vendemiale).
Tommaso CassanoDepartment of Physiology and Pharmacology, Sapienza University of Rome, Italy (Drs Romano, Tempesta, Lavecchia, Bedse, and Gaetani); Department of Clinical and Experimental Medicine, University of Foggia, Italy (Drs Pace, Macheda, and Cassano); Puglia and Basilicata Experimental Zooprophylactic Institute, Foggia, Italy (Dr Petrella); School of Pharmacy, Pharmacology Unit, University of Camerino, Italy (Dr Cifani); Department of Medical and Surgical Sciences, University of Foggia, Italy (Drs Serviddio and Vendemiale). tommaso.cassano@unifg.it.
University of Foggia · ITUniversità di Camerino · ITIstituto Zooprofilattico Sperimentale della Puglia e della Basilicata · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeuropsychiatric signs are critical in primary caregiving of Alzheimer patients and have not yet been fully investigated in murine models.

methods18-month-old 3×Tg-AD male mice and their wild-type male littermates (non-Tg) were used. The open field test and the elevated plus maze test were used to evaluate anxiety-like behaviors, whereas the Porsolt forced swim test, the tail suspension test, and the sucrose preference test for antidepressant/depression-coping behaviors. Neurochemical study was conducted by microdialysis in freely-moving mice, analyzing the basal and K(+)-stimulated monoamine output in the frontal cortex and ventral hippocampus. Moreover by immunohistochemistry, we analysed the expression of Tyrosin hydroxylase and Tryptophan hydroxylase, which play a key role in the synthesis of monoamines.

resultsAged 3×Tg-AD mice exhibited a higher duration of immobility in the forced swim and tail suspension tests (predictors of depression-like behavior) which was not attenuated by a noradrenaline reuptake inhibitor, desipramine. In the sucrose preference test, 3×Tg-AD mice showed a significantly lower sucrose preference compared to the non-Tg group, without any difference in total fluid intake. In contrast, the motor functions and anxiety-related emotional responses of 3×Tg-AD mice were normal, as detected by the open-field and elevated plus-maze tests. To strengthen these results, we then evaluated the monoaminergic neurotransmissions by in vivo microdialysis and immunohistochemistry. In particular, with the exception of the basal hippocampal dopamine levels, 3×Tg-AD mice exhibited a lower basal extracellular output of amines in the frontal cortex and ventral hippocampus and also a decreased extracellular response to K(+) stimulation. Such alterations occur with obvious local amyloid-β and tau pathologies and without gross alterations in the expression of Tyrosin and Tryptophan hydroxylase.

conclusionsThese results suggest that 3×Tg-AD mice exhibit changes in depression-related behavior involving aminergic neurotrasmitters and provide an animal model for investigating AD with depression.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsAnxietyBiogenic MonoaminesBrainCentral Nervous System AgentsDepressionDisease Models, AnimalExtracellular SpaceMaleMice, 129 StrainMice, Inbred C57BLMice, TransgenicMotor ActivityPotassiumAmyloid beta-PeptidesBiogenic MonoaminesCentral Nervous System AgentsMapt protein, mousePotassiumtau ProteinsTryptophan HydroxylaseTyrosine 3-Monooxygenaseanxietydepressionfrontal cortexhippocampusmonoaminergic neurotransmissiontriple transgenic model of AD

Identifiers

PMID25609597
PMCPMC4360228
OpenAlexW2157314020

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.