Evidence map›Paper›PMID 25609449›Full record

SynthesisBMC health services research2015

Longitudinal and cross sectional assessments of health utility in adults with HIV/AIDS: a systematic review and meta-analysis.

Bach Xuan Tran, Long Hoang Nguyen, Arto Ohinmaa, Rachel Marie Maher, Vuong Minh Nong, Carl A Latkin

Open access · goldAbstract readComparative StudyMeta-AnalysisSystematic Review
In one paragraph

Synthesis in BMC health services research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 5 pooled it
26.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 5 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. An international compendium of health state utilities in people with HIV: a systematic review.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
    Pooled it
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  4. Time trade-off health state utility values for depression: a systematic review and meta-analysis.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023
    Pooled it
  5. Pooled it
  6. A head-to-head comparison of health utilities and measurement properties of the EQ-5D-5L and SF-6Dv2 among people living with HIV in China.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
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  12. Sex Differences in Quality of Life and Health Services Utilization among Elderly People in Rural Vietnam.International journal of environmental research and public health · 2018
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  15. Cost-Effectiveness of Community-based Human Immunodeficiency Virus Self-Testing in Blantyre, Malawi.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018
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  18. Risks associated with antiretroviral treatment for human immunodeficiency virus (HIV): qualitative analysis of social media data and health state utility valuation.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Bach Xuan TranJohns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. bach@jhu.edu.
Long Hoang NguyenSchool of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam. nhlong.smp@vnu.edu.vn.
Arto OhinmaaSchool of Public Health, University of Alberta, Edmonton, Alberta, Canada. arto.ohinmaa@ualberta.ca.
Rachel Marie MaherInstitute for Preventive Medicine and Public Health, Hanoi Medical University, Hanoi, Vietnam. maher.rachel9@gmail.com.
Vuong Minh NongInstitute for Preventive Medicine and Public Health, Hanoi Medical University, Hanoi, Vietnam. nongminhvuong.hmu@gmail.com.
Carl A LatkinJohns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. clatkin@jhsph.edu.
Hanoi Medical University · VNJohns Hopkins University · USUniversity of Alberta · CAVietnam National University, Hanoi · VN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUtility estimates are important health outcomes for economic evaluation of care and treatment interventions for patients with HIV/AIDS. We conducted a systematic review and meta-analysis of utility measurements to examine the performance of preference-based instruments, estimate health utility of patients with HIV/AIDS by disease stages, and investigate changes in their health utility over the course of antiretroviral treatment.

methodsWe searched PubMed/Medline, Cochrane Database of Systematic Review, NHS Economic Evaluation Database and Web of Science for English-language peer-reviewed papers published during 2000-2013. We selected 49 studies that used 3 direct and 6 indirect preference based instruments to make a total of 218 utility measurements. Random effect models with robust estimation of standard errors and multivariate fractional polynomial regression were used to obtain the pooled estimates of utility and model their trends.

resultsReliability of direct-preference measures tended to be lower than other types of measures. Utility elicited by two of the indirect preference measures - SF-6D (0.171) and EQ-5D (0.114), and that of Time-Trade off (TTO) (0.151) was significantly different than utility elicited by Standard Gamble (SG). Compared to asymptomatic HIV patients, symptomatic and AIDS patients reported a decrement of 0.025 (p = 0.40) and 0.176 (p = 0.001) in utility scores, adjusting for method of assessment. In longitudinal studies, the pooled health utility of HIV/AIDS patients significantly decreased in the first 3 months of treatment, and rapidly increased afterwards. Magnitude of change varied depending on the method of assessment and length of antiretroviral treatment.

conclusionThe study provides an accumulation of evidence on measurement properties of health utility estimates that can help inform the selection of instruments for future studies. The pooled estimates of health utilities and their trends are useful in economic evaluation and policy modelling of HIV/AIDS treatment strategies.

Indexed as

Acquired Immunodeficiency SyndromeAdultAnti-Retroviral AgentsCross-Sectional StudiesData Interpretation, StatisticalDelivery of Health CareFemaleHIV InfectionsHumansLongitudinal StudiesMaleMiddle AgedPatient Acceptance of Health CareQuality of LifeRegression AnalysisReproducibility of ResultsAnti-Retroviral Agents

Identifiers

PMID25609449
PMCPMC4307193
OpenAlexW2057519625

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.