ReviewToxins2015
Diversification of ergot alkaloids in natural and modified fungi.
Review in Toxins, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 63 citations in OpenAlex.
- A Concise and Divergent Approach to the Naturally Occurring Tetracyclic Clavine Alkaloids (+)-Lysergol, (+)-Lysergine, and (+)-Isolysergine.The Journal of organic chemistry · 2025Article
- New entomopathogenic species in the Clavicipitaceae family (Hypocreales, Ascomycota) from the subtropical forests of Fujian, China.Frontiers in microbiology · 2025Article
- Two Satellite Gene Clusters Enhance Ergot Alkaloid Biosynthesis Capacity of AspergillusApplied and environmental microbiology · 2023Article
- Derivation of the multiply-branched ergot alkaloid pathway of fungi.Microbial biotechnology · 2023Review
- Underreported Human Exposure to Mycotoxins: The Case of South Africa.Foods (Basel, Switzerland) · 2022Review
- Construction of an efficientFrontiers in bioengineering and biotechnology · 2022Article
- Evolution of the Ergot Alkaloid Biosynthetic Gene Cluster Results in Divergent Mycotoxin Profiles inToxins · 2021Article
- Independent Evolution of a Lysergic Acid Amide in Aspergillus Species.Applied and environmental microbiology · 2021Article
- Article
- A Baeyer-Villiger Monooxygenase Gene Involved in the Synthesis of Lysergic Acid Amides Affects the Interaction of the Fungus Metarhizium brunneum with Insects.Applied and environmental microbiology · 2021Article
- Mycotoxins Affecting Animals, Foods, Humans, and Plants: Types, Occurrence, Toxicities, Action Mechanisms, Prevention, and Detoxification Strategies-A Revisit.Foods (Basel, Switzerland) · 2021Review
- Natural products in the predatory defence of the filamentous fungal pathogenBeilstein journal of organic chemistry · 2021Review
- Genetic Reprogramming of the Ergot Alkaloid Pathway of Metarhizium brunneum.Applied and environmental microbiology · 2020Article
- Several Metarhizium Species Produce Ergot Alkaloids in a Condition-Specific Manner.Applied and environmental microbiology · 2020Article
- Natural Ergot Alkaloids in Ocular Pharmacotherapy: Known Molecules for Novel Nanoparticle-Based Delivery Systems.Biomolecules · 2020Review
- Toxicity Studies of Chanoclavine in Mice.Toxins · 2019Article
- Biological activity of Claviceps gigantea in juvenile New Zealand rabbits.Mycotoxin research · 2018Article
- Ergot Alkaloid Synthesis Capacity of Penicillium camemberti.Applied and environmental microbiology · 2018Article
- Ergot Alkaloid Biosynthesis in the Maize (Zea mays) Ergot Fungus Claviceps gigantea.Journal of agricultural and food chemistry · 2017Article
- Clavine Alkaloids Gene Clusters ofGenes · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several fungi in two different families--the Clavicipitaceae and the Trichocomaceae--produce different profiles of ergot alkaloids, many of which are important in agriculture and medicine. All ergot alkaloid producers share early steps before their pathways diverge to produce different end products. EasA, an oxidoreductase of the old yellow enzyme class, has alternate activities in different fungi resulting in branching of the pathway. Enzymes beyond the branch point differ among lineages. In the Clavicipitaceae, diversity is generated by the presence or absence and activities of lysergyl peptide synthetases, which interact to make lysergic acid amides and ergopeptines. The range of ergopeptines in a fungus may be controlled by the presence of multiple peptide synthetases as well as by the specificity of individual peptide synthetase domains. In the Trichocomaceae, diversity is generated by the presence or absence of the prenyl transferase encoded by easL (also called fgaPT1). Moreover, relaxed specificity of EasL appears to contribute to ergot alkaloid diversification. The profile of ergot alkaloids observed within a fungus also is affected by a delayed flux of intermediates through the pathway, which results in an accumulation of intermediates or early pathway byproducts to concentrations comparable to that of the pathway end product.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.