ArticleJournal of neurophysiology2015
Synchronization of action potentials during low-magnesium-induced bursting.
Article in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Synaptic and intrinsic membrane defects disrupt early neural network dynamics in Down syndrome.Nature communications · 2026Article
- Connectivity and Neuronal Synchrony during Seizures.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Difluoroboron β-diketonate polylactic acid oxygen nanosensors for intracellular neuronal imaging.Scientific reports · 2021Article
- Progesterone receptor activation regulates seizure susceptibility.Annals of clinical and translational neurology · 2019Article
- ZDHHC8 critically regulates seizure susceptibility in epilepsy.Cell death & disease · 2018Article
- Article
- Metallomic Biomarkers in Cerebrospinal fluid and Serum in patients with Parkinson's disease in Indian population.Scientific reports · 2016Article
- Increased excitability and excitatory synaptic transmission during in vitro ischemia in the neonatal mouse hippocampus.Neuroscience · 2015Article
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The relationship between mono- and polysynaptic strength and action potential synchronization was explored using a reduced external Mg(2+) model. Single and dual whole cell patch-clamp recordings were performed in hippocampal cultures in three concentrations of external Mg(2+). In decreased Mg(2+) medium, the individual cells transitioned to spontaneous bursting behavior. In lowered Mg(2+) media the larger excitatory synaptic events were observed more frequently and fewer transmission failures occurred, suggesting strengthened synaptic transmission. The event synchronization was calculated for the neural action potentials of the cell pairs, and it increased in media where Mg(2+) concentration was lowered. Analysis of surrogate data where bursting was present, but no direct or indirect connections existed between the neurons, showed minimal action potential synchronization. This suggests the synchronization of action potentials is a product of the strengthening synaptic connections within neuronal networks.
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Registered trials
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