ArticleAmerican journal of physiology. Renal physiology2015
Identification and function of adenosine A3 receptor in afferent arterioles.
Article in American journal of physiology. Renal physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- A3 Adenosine Receptor Agonists as Multisystem Disease Modifiers: From Molecular Signaling to Clinical Translation.Biomolecules · 2026Review
- Purinoceptor: a novel target for hypertension.Purinergic signalling · 2023Review
- Gene expression pattern of adenosine receptors in lung tumors.Cancer reports (Hoboken, N.J.) · 2023Article
- Adenosine receptors as emerging therapeutic targets for diabetic kidney disease.Kidney research and clinical practice · 2022Article
- Adenosine AMolecular and cellular biochemistry · 2021Article
- Purinoceptors, renal microvascular function and hypertension.Physiological research · 2020Review
- Aging Impairs Renal Autoregulation in Mice.Hypertension (Dallas, Tex. : 1979) · 2020Article
- NaHCOHypertension (Dallas, Tex. : 1979) · 2019Article
- Glucose dilates renal afferent arterioles via glucose transporter-1.American journal of physiology. Renal physiology · 2018Article
- Adenosine AAmerican journal of physiology. Renal physiology · 2017Article
- Enhanced hemodynamic responses to angiotensin II in diabetes are associated with increased expression and activity of AT1 receptors in the afferent arteriole.Physiological genomics · 2017Article
- Genetic Abrogation of Adenosine A3 Receptor Prevents Uninephrectomy and High Salt-Induced Hypertension.Journal of the American Heart Association · 2016Article
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
Adenosine plays an important role in regulation of renal microcirculation. All receptors of adenosine, A1, A2A, A2B, and A3, have been found in the kidney. However, little is known about the location and function of the A3 receptor in the kidney. The present study determined the expression and role of A3 receptors in mediating the afferent arteriole (Af-Art) response and studied the interaction of A3 receptors with angiotensin II (ANG II), A1 and A2 receptors on the Af-Art. We found that the A3 receptor expressed in microdissected isolated Af-Art and the mRNA levels of A3 receptor were 59% of A1. In the isolated microperfused Af-Art, A3 receptor agonist IB-MECA did not have a constrictive effect. Activation of A3 receptor dilated the preconstricted Af-Art by norepinephrine and blunted the vasoconstrictive effect of both adenosine A1 receptor activation and ANG II on the Af-Art, respectively. Selective A2 receptor antagonist (both A2A and A2B) had no effect on A3 receptor agonist-induced vasodilation, indicating that the dilatory effect of A3 receptor activation is not mediated by activation of A2 receptor. We conclude that the A3 receptor is expressed in the Af-Art, and activation of the A3 receptor dilates the Af-Art.
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