ArticleIn vitro cellular & developmental biology. Animal2015
Thyroid hormone responsive protein spot 14 enhances lipogenesis in bovine mammary epithelial cells.
Article in In vitro cellular & developmental biology. Animal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 38 citations in OpenAlex.
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- Research Progress on the Mechanism of Milk Fat Synthesis in Cows and the Effect of Conjugated Linoleic Acid on Milk Fat Metabolism and Its Underlying Mechanism: A Review.Animals : an open access journal from MDPI · 2024Review
- Progress of Conjugated Linoleic Acid on Milk Fat Metabolism in Ruminants and Humans.Animals : an open access journal from MDPI · 2023Review
- Association betweenAnimals : an open access journal from MDPI · 2021Article
- Regulation of Key Genes for Milk Fat Synthesis in Ruminants.Frontiers in nutrition · 2021Review
- Effects of Dietary Vegetable Oils on Mammary Lipid-Related Genes in Holstein Dairy Cows.Animals : an open access journal from MDPI · 2019Article
- GRP78 regulates milk biosynthesis and the proliferation of bovinemammaryepithelial cells through the mTOR signaling pathway.Cellular & molecular biology letters · 2019Article
- mTORC2 Regulates Lipogenic Gene Expression through PPARBioMed research international · 2019Article
- DEAD-box helicase 6 (DDX6) is a new negative regulator for milk synthesis and proliferation of bovine mammary epithelial cells.In vitro cellular & developmental biology. Animal · 2018Article
- MiR-139 suppresses β-casein synthesis and proliferation in bovine mammary epithelial cells by targeting the GHR and IGF1R signaling pathways.BMC veterinary research · 2017Article
- Expression of Thyroid Hormone Responsive SPOT 14 Gene Is Regulated by Estrogen in Chicken (Gallus gallus).Scientific reports · 2017Article
- Sebaceous Gland Atrophy in Psoriasis: An Explanation for Psoriatic Alopecia?The Journal of investigative dermatology · 2016Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thyroid hormone responsive spot 14 (THRSP, Spot14, S14) is a nuclear protein that regulates milk fat synthesis. To investigate the role of THRSP in lipogenesis in the dairy cow mammary gland, first, we examined the association between milk fat concentration and THRSP expression in the mammary gland. We found that the dairy cow mammary glands that produced milk with high fat had high THRSP mRNA and protein levels. Additionally, the study described the consequences of overexpression or depletion of THRSP on lipogenesis in cultured bovine mammary epithelial cells (BMECs). We found that BMECs with overexpressed THRSP increased triacylglycerol levels and enhanced the expression of FAS, PPARγ, and SREBP1, compared with the control BMECs. Depletion of THRSP produced the opposite effects. Overall, increased mammary expression of THRSP can be a marker of high fat. In addition, our results provide evidence that THRSP may regulate expression of PPARγ and SREBP1 and can regulate milk fat synthesis by directly affecting the activity of some classical lipogenic enzymes.
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