ArticleBMC family practice2015
Trajectories of multimorbidity: exploring patterns of multimorbidity in patients with more than ten chronic health problems in life course.
Article in BMC family practice, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Health-Related Quality of Life and Its Association With Multimorbidity Among University Students in Jeddah, Saudi Arabia: A Cross-Sectional Study.Journal of patient experience · 2026Article
- Investigating multimorbidity trajectories in people living with MASLD diagnosis: A trajectory analysis using the UK Biobank.Diabetes, obesity & metabolism · 2025Article
- Unraveling cradle-to-grave disease trajectories from multilayer comorbidity networks.NPJ digital medicine · 2024Article
- Comorbidity Patterns in Patients at Cardiovascular Hospital Admission.Medicines (Basel, Switzerland) · 2023Article
- Joint frailty modeling of time-to-event data to elicit the evolution pathway of events: a generalized linear mixed model approach.Biostatistics (Oxford, England) · 2022Article
- 12-year evolution of multimorbidity patterns among older adults based on Hidden Markov Models.Aging · 2022Article
- Different definitions of multimorbidity and their effect on prevalence rates: a retrospective study in German general practices.Primary health care research & development · 2022Observational
- Fifteen-year trajectories of multimorbidity and polypharmacy in Dutch primary care-A longitudinal analysis of age and sex patterns.PloS one · 2022Article
- Increases in multimorbidity with weight class in the United States.Clinical obesity · 2021Article
- Article
- Cohort profile: The prospective study on Chinese elderly with multimorbidity in primary care in Hong Kong.BMJ open · 2020Article
- MorbiNet: multimorbidity networks in adult general population. Analysis of type 2 diabetes mellitus comorbidity.Scientific reports · 2020Article
- Pattern of Cardiac Diseases and Co-Existing Morbidities Among Newly Registered Cardiac Patients in an Adult Cardiac Referral Clinic of Hawassa University Comprehensive Specialized Hospital, Southern-Ethiopia.Vascular health and risk management · 2020Article
- Comorbidity in patients with cardiovascular disease in primary care: a cohort study with routine healthcare data.The British journal of general practice : the journal of the Royal College of General Practitioners · 2019Article
- Racial/ethnic differences in multimorbidity development and chronic disease accumulation for middle-aged adults.PloS one · 2019Article
- Onset of Multiple Chronic Conditions and Depressive Symptoms: A Life Events Perspective.Innovation in aging · 2017Article
- Lifetime Modulation of the Pain SystemFrontiers in immunology · 2017Review
- A Biobehavioral Framework to Address the Emerging Challenge of Multimorbidity.Psychosomatic medicine · 2016Review
- Examining the prevalence and patterns of multimorbidity in Canadian primary healthcare: a methodologic protocol using a national electronic medical record database.Journal of comorbidity · 2015Article
- The effect of disease onset chronology on mortality among patients with multimorbidity: A Danish nationwide register study.Journal of multimorbidity and comorbidityArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPhysicians are frequently confronted with complex health situations of patients, but knowledge of intensive forms of multimorbidity and their development during life is lacking. This study explores patterns and trajectories of chronic health problems of patients with multimorbidity particularly those with more than ten conditions and type and variety of organ systems involved in these patterns during life.
methodLife time prevalence patterns of chronic health problems were determined in patients with illness trajectories accumulating more than ten chronic health problems during life as registered by general practitioners in the South of the Netherlands in the Registration Network Family Practices (RNH).
resultsOverall 4,560 subjects (5%) were registered with more than ten chronic health problems during their life (MM11+), accounting for 61,653 (20%) of the 302,808 registered health problems in the population (N = 87,837 subjects). More than 30% accumulates 4 or more chronic health conditions (MM4-5: 4-5 conditions (N = 14,199; 16.2%); MM6-10: 6-10 conditions (N = 14,365; 16.4%). Gastro-intestinal, cardiovascular, locomotor, respiratory and metabolic conditions occur more frequently in the MM11+ patients than in the other patients, while the nature and variety of body systems involved in lifetime accumulation of chronic health problem clusters is both generic and specific. Regarding chronic conditions afflicting multiple sites throughout the body, the number of neoplasms seems low (N = 3,592; 5.8%), but 2,461 (49%) of the 4,560 subjects have registered at least one neoplasm condition during life. A similar pattern is noted for inflammation (N = 3,537, 78%), infection (N = 2,451, 54%) and injury (N = 3,401, 75%).
conclusionThere are many challenges facing multimorbidity research, including the implementation of a longitudinal, life-time approach from a family practice perspective. The present study, although exploratory by nature, shows that both general and specific mechanisms characterize the development of multimorbidity trajectories. A small proportion of patients has a high number of chronic health problems (MM11+) and keeps adding health problems during life. However, GP's need to realise that more than one third of their patients accumulate four or more chronic health problems (MM4-5 and MM6-10) during life.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.