ArticleNature communications2015
Osmotic pressure induced tensile forces in tendon collagen.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
71 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Elastography in the assessment of the Achilles tendon: a systematic review of measurement properties.Journal of foot and ankle research · 2023Pooled it
- Bone-like Collagen Matrices Through Rapid Intrafibrillar Mineralisation.Journal of functional biomaterials · 2026Article
- Effect of soft tissue sample preparation techniques for scanning small-angle X-ray scattering experiments.Journal of synchrotron radiation · 2026Article
- Analysis of Multi-Component Echo Decay in Achilles Tendon by NMR Spectroscopy.NMR in biomedicine · 2026Article
- Elastic Energy Storage in Biological Materials: Internal Stresses and Their Functionality.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Article
- Water and Collagen: A Mystery Yet to Unfold.Biomacromolecules · 2025Review
- Water and ions binding to extracellular matrix drives stress relaxation, aiding MRI detection of swelling-associated pathology.Nature biomedical engineering · 2025Article
- Cell-matrix feedback controls stretch-induced cellular memory and fibroblast activation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Nonlinear Stress-Induced Transformations in Collagen Fibrillar Organization, Disorder and Strain Mechanisms in the Bone-Cartilage Unit.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Investigating the impact of dehydration and hydration on In-Vivo hip soft tissue biomechanics.PloS one · 2025Article
- Bone collagen tensile properties of the aging human proximal femur.Bone reports · 2024Article
- Article
- Effects of novel raloxifene analogs alone or in combination with mechanical loading in the Col1a2Bone · 2024Article
- Article
- Article
- Tensile properties of freeze-cast collagen scaffolds: How processing conditions affect structure and performance in the dry and fully hydrated states.Journal of the mechanical behavior of biomedical materials · 2023Article
- Beneficial Effects of Zoledronic Acid on Tendons of the Osteogenesis Imperfecta Mouse (Oim).Pharmaceuticals (Basel, Switzerland) · 2023Article
- Collagen breaks at weak sacrificial bonds taming its mechanoradicals.Nature communications · 2023Article
- Submicron-Sized In Situ Osmotic Pressure Sensors for In Vitro Applications in Biology.Advanced healthcare materials · 2023Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Water is an important component of collagen in tendons, but its role for the function of this load-carrying protein structure is poorly understood. Here we use a combination of multi-scale experimentation and computation to show that water is an integral part of the collagen molecule, which changes conformation upon water removal. The consequence is a shortening of the molecule that translates into tensile stresses in the range of several to almost 100 MPa, largely surpassing those of about 0.3 MPa generated by contractile muscles. Although a complete drying of collagen would be relevant for technical applications, such as the fabrication of leather or parchment, stresses comparable to muscle contraction already occur at small osmotic pressures common in biological environments. We suggest, therefore, that water-generated tensile stresses may play a role in living collagen-based materials such as tendon or bone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.