Evidence map›Paper›PMID 25608575›Full record

ReviewAnnals of gastroenterology

Cardiovascular dysfunction in patients with liver cirrhosis.

Giuseppe Fede, Graziella Privitera, Tania Tomaselli, Luisa Spadaro, Francesco Purrello

Open access · greenAbstract readReview
PubMed Full text at PMC
In one paragraph

Review in Annals of gastroenterology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 1 pooled it
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 1 synthesis or guideline pooled it, 143 citations in OpenAlex.

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  12. Discordant High-Gradient Aortic Stenosis: A Systematic Review.Journal of cardiovascular development and disease · 2025
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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Giuseppe FedeDepartment of Clinical and Molecular Biomedicine, University of Catania, Garibaldi Hospital, Catania, Italy.
Graziella PriviteraDepartment of Clinical and Molecular Biomedicine, University of Catania, Garibaldi Hospital, Catania, Italy.
Tania TomaselliDepartment of Clinical and Molecular Biomedicine, University of Catania, Garibaldi Hospital, Catania, Italy.
Luisa SpadaroDepartment of Clinical and Molecular Biomedicine, University of Catania, Garibaldi Hospital, Catania, Italy.
Francesco PurrelloDepartment of Clinical and Molecular Biomedicine, University of Catania, Garibaldi Hospital, Catania, Italy.
University of Catania · ITOspedale Garibaldi · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyperdynamic syndrome is a well-known clinical condition found in patients with cirrhosis and portal hypertension, characterized by increased heart rate and cardiac output, and reduced systemic vascular resistance and arterial blood pressure. The leading cause of hyperdynamic circulation in cirrhotic patients is peripheral and splanchnic vasodilatation, due to an increased production/activity of vasodilator factors and decreased vascular reactivity to vasoconstrictors. The term "cirrhotic cardiomyopathy" describes impaired contractile responsiveness to stress, diastolic dysfunction and electrophysiological abnormalities in patients with cirrhosis without known cardiac disease. Underlying circulatory and cardiac dysfunctions are the main determinant in the development of hepatorenal syndrome in advanced cirrhosis. Moreover, the clinical consequences of cirrhosis-related cardiovascular dysfunction are evident during and after liver transplantation, and after transjugular intrahepatic portosystemic shunt insertion. Cardiovascular complications following these procedures are common, with pulmonary edema being the most common complication. Other complications include overt heart failure, arrhythmia, pulmonary hypertension, pericardial effusion, and cardiac thrombus formation. This review discusses the circulatory and cardiovascular dysfunctions in cirrhosis, examining the pathophysiologic and clinical implications in light of the most recent published literature.

Indexed as

cardiovascular dysfunctioncirrhosiscirrhotic cardiomyopathyKeywords Hyperdynamic syndrome

Identifiers

PMID25608575
PMCPMC4290002
OpenAlexW2147129983

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.