Evidence map›Paper›PMID 25608529›Full record

ArticleEMBO reports2015

IP3 signalling regulates exogenous RNAi in Caenorhabditis elegans.

Anikó I Nagy, Rafael P Vázquez-Manrique, Marie Lopez, Christo P Christov, María Dolores Sequedo, Mareike Herzog, Anna E Herlihy, Maxime Bodak, Roxani Gatsi, Howard A Baylis

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Anikó I NagyDepartment of Zoology, University of Cambridge, Cambridge, UK.
Rafael P Vázquez-ManriqueResearch Group in Molecular, Cellular and Genomic Biomedicine, Health Research Institute-La Fe, Valencia, Spain Centre for Biomedical Network Research on Rare Diseases (CIBERER), Valencia, Spain.
Marie LopezDepartment of Zoology, University of Cambridge, Cambridge, UK.
Christo P ChristovDepartment of Zoology, University of Cambridge, Cambridge, UK.
María Dolores SequedoResearch Group in Molecular, Cellular and Genomic Biomedicine, Health Research Institute-La Fe, Valencia, Spain Centre for Biomedical Network Research on Rare Diseases (CIBERER), Valencia, Spain.
Mareike HerzogDepartment of Zoology, University of Cambridge, Cambridge, UK.
Anna E HerlihyDepartment of Zoology, University of Cambridge, Cambridge, UK.
Maxime BodakDepartment of Zoology, University of Cambridge, Cambridge, UK.
Roxani GatsiDepartment of Zoology, University of Cambridge, Cambridge, UK.
Howard A BaylisDepartment of Zoology, University of Cambridge, Cambridge, UK hab28@cam.ac.uk.
University of Cambridge · GBCentre for Biomedical Network Research on Rare Diseases · ES

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Medical Research Council G0601106NIH HHS P40 OD010440
6 · The paper itself

Abstract

RNA interference (RNAi) is a widespread and widely exploited phenomenon. Here, we show that changing inositol 1,4,5-trisphosphate (IP3) signalling alters RNAi sensitivity in Caenorhabditis elegans. Reducing IP3 signalling enhances sensitivity to RNAi in a broad range of genes and tissues. Conversely up-regulating IP3 signalling decreases sensitivity. Tissue-specific rescue experiments suggest IP3 functions in the intestine. We also exploit IP3 signalling mutants to further enhance the sensitivity of RNAi hypersensitive strains. These results demonstrate that conserved cell signalling pathways can modify RNAi responses, implying that RNAi responses may be influenced by an animal's physiology or environment.

Indexed as

AnimalsCaenorhabditis elegansImage Processing, Computer-AssistedInositol 1,4,5-TrisphosphateIntestinal MucosaMicroscopy, FluorescenceModels, BiologicalRNA, Double-StrandedRNA InterferenceSignal TransductionInositol 1,4,5-TrisphosphateRNA, Double-Strandedcalcium signallingC. elegansenhanced RNAiinositol 1,4,5‐trisphosphateRNA interference

Identifiers

PMID25608529
PMCPMC4353841
OpenAlexW2145662150

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.