ArticleInternational journal of colorectal disease2015
Increased risk of stroke among patients with Crohn's disease: a population-based matched cohort study.
Article in International journal of colorectal disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 4 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Risk of stroke in patients with inflammatory bowel disease: a systematic review and meta-analysis.BMC gastroenterology · 2025Pooled it
- Pooled it
- Association between inflammatory bowel disease and risk of stroke: a systematic review and meta-analysis of cohort studies.Frontiers in neurology · 2023Pooled it
- Increased risk of stroke among patients with inflammatory bowel disease: A PRISMA-compliant meta-analysis.Brain and behavior · 2021Pooled it
- Review
- The role of digestive system diseases in cerebrovascular disease: a comprehensive Mendelian randomization study.Frontiers in neurology · 2024Article
- Atherosclerotic cardiovascular diseases in inflammatory bowel diseases: to theFrontiers in cardiovascular medicine · 2023Review
- Relationships Among Gut Microbiota, Ischemic Stroke and Its Risk Factors: Based on Research Evidence.International journal of general medicine · 2022Review
- An Investigation into the Association Between Inflammatory Bowel Disease and Cardiac Arrhythmias: An Examination of the United States National Inpatient Sample Database.Clinical Medicine Insights. Cardiology · 2020Article
- Gut Microbiota in Acute Ischemic Stroke: From Pathophysiology to Therapeutic Implications.Frontiers in neurology · 2020Review
- The Risk of Cerebrovascular Accidents in Inflammatory Bowel Disease in the United States: A Population-Based National Study.Clinical and experimental gastroenterology · 2020Article
- Neurological manifestations related to Crohn's disease: a boon for the workforce.Gastroenterology report · 2019Article
- Epidemiology and Clinical Outcomes of Inflammatory Bowel Disease: A Hospital-Based Study in Central Taiwan.Gastroenterology research and practice · 2019Article
- Increased risk of periodontitis among patients with Crohn's disease: a population-based matched-cohort study.International journal of colorectal disease · 2018Article
- Emerging Role of Diet and Microbiota Interactions in Neuroinflammation.Frontiers in immunology · 2018Review
- Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells.Nature medicine · 2016Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCrohn's disease (CD) is one type of inflammatory bowel disease (IBD) that has been speculated to share prognostic factors with the development of stroke. There is controversial information in the literature regarding the association between CD and stroke. The present cohort study estimated the risk of subsequent stroke among CD patients compared with matched comparison subjects drawn from a population-based dataset in Taiwan.
methodThis study drew data from the Taiwan National Health Insurance Database to conduct a historical cohort study. The study cohort comprised 3309 CD patients, and the comparison cohort comprised 13,236 subjects without an IBD. Cox proportional hazards regressions were performed to estimate the risk of subsequent stroke during the follow-up period. We also conducted additional analyses stratifying by age group and gender.
resultsAfter adjusting for selected medical co-morbidities and recent prescriptions of selected pharmaceuticals, the hazard ratio (HR) for subsequent stroke among patients with CD was found to be 1.911 (95% confidence interval (CI) = 1.65-2.22) that of comparison subjects. While we did not detect an association between stroke and CD among patients aged 30-40 years, we did detect increased risks for stroke among CD patients aged 40-50 years (HR = 2.29) and those aged over 50 years (HR = 1.88). We also found women (HR = 2.39) to be at a greater risk than men (HR = 1.50).
conclusionThis study reports an increased HR for subsequent stroke among CD patients when compared to matched comparison patients without IBD in an Asian population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.