ArticleClinical nuclear medicine2015
Do 18F-FDG PET/CT parameters in oropharyngeal and oral cavity squamous cell carcinomas indicate HPV status?
Article in Clinical nuclear medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Role of 18F-FDG PET/CT in evaluating lymph node status in patients with head and neck squamous cell carcinoma.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2023Article
- Role of PET/CT in Oropharyngeal Cancers.Cancers · 2023Review
- Imaging of human papilloma virus associated oropharyngeal squamous cell carcinoma and its impact on diagnosis, prognostication, and response assessment.The British journal of radiology · 2022Review
- Article
- Advances in Imaging for HPV-Related Oropharyngeal Cancer: Applications to Radiation Oncology.Seminars in radiation oncology · 2021Review
- The ability of post-chemoradiotherapy DWI ADCJournal of cancer research and clinical oncology · 2021Observational
- Texture indices of 4'-[methyl-European journal of hybrid imaging · 2020Article
- Positron emission tomography objective parameters for assessment of left ventricular assist device infection usingAmerican journal of nuclear medicine and molecular imaging · 2020Article
- Comparison of Imaging Findings between Human Papillomavirus-positive and -Negative Squamous Cell Carcinomas of the Maxillary Sinus.Journal of clinical imaging science · 2020Article
- PET-based prognostic survival model after radiotherapy for head and neck cancer.European journal of nuclear medicine and molecular imaging · 2019Article
- Association of Fludeoxyglucose F 18-Labeled Positron Emission Tomography and Computed Tomography With the Detection of Oropharyngeal Cancer Recurrence.JAMA otolaryngology-- head & neck surgery · 2018Article
- Is There a Role for PET/CT Parameters to Characterize Benign, Malignant, and Metastatic Parotid Tumors?AJR. American journal of roentgenology · 2016Article
- Is there a role for PET/CT parameters to differentiate thyroid cartilage invasion from penetration?European journal of radiology · 2016Article
- Correlation of PET-CT nodal SUVmax with p16 positivity in oropharyngeal squamous cell carcinoma.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale · 2015Article
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Authors and funding
12 authors.
Funding
Abstract
objectiveThe aim of this study was to explore the relationship of PET/CT parameters with human papillomavirus (HPV) status of oropharyngeal (OP) and oral cavity (OC) squamous cell carcinomas (SCCs). PATIENTS AND
methodsWe retrospectively reviewed 39 patients with OC and OP-SCC who underwent staging 18F-FDG PET/CT. PET/CT parameters were measured for the primary tumor and the hottest involved node, including SUV max, SUV mean, SUV peak, metabolic tumor volume, total lesion glycolysis, standardized added metabolic activity (SAM), and normalized SAM. Patient characteristics were compared between HPV positive (HPV+) and negative (HPV-) groups. Receiver operating characteristic analysis was used to dichotomize PET/CT parameters into high and low. Logistic regression models predicting HPV status were fit for each PET/CT parameter.
resultsThe HPV+ group was composed of 18 patients all with OP-SCC; the HPV- group consisted of 21 patients, 4 OP cancer patients and 17 OC cancer patients. The HPV+ group had a higher proportion of N2 stage (94% vs 43%; P < 0.001). Nodal PET/CT parameters were higher in the HPV+ group (P < 0.01); this difference was not present for the primary lesion. After adjusting for sex and age, the association of higher nodal SUV max (odds ratio [OR], 9.67), SUV mean (OR, 10.48), SUV peak (OR 9.67), metabolic tumor volume (OR, 14.52), total lesion glycolysis (OR, 11.84), and SAM, normalized SAM (OR, 16.21) with HPV+ status remained statistically significant (P < 0.05).
conclusionsNodal PET/CT parameters predict HPV status. High nodal FDG uptake should raise suspicion for positive HPV status in the evaluation of the primary lesion.
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