ArticleMolecules (Basel, Switzerland)2015
Inhibition of urinary macromolecule heparin on aggregation of nano-COM and nano-COD crystals.
Article in Molecules (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- SulfatedPharmaceuticals (Basel, Switzerland) · 2024Article
- CarboxymethylatedBiomolecules · 2023Article
- Application of metabolomics in urolithiasis: the discovery and usage of succinate.Signal transduction and targeted therapy · 2023Article
- Article
- Antioxidant Sulfated Polysaccharide from Edible Red SeaweedMolecules (Basel, Switzerland) · 2020Article
- Aggregation of poorly crystalline and amorphous components of infectious urinary stones is mediated by bacterial lipopolysaccharide.Scientific reports · 2019Article
- In Vitro Studies Reveal Antiurolithic Effect of Antioxidant Sulfated Polysaccharides from the Green SeaweedMarine drugs · 2019Article
- Gallic Acid-Chitosan Conjugate Inhibits the Formation of Calcium Oxalate Crystals.Molecules (Basel, Switzerland) · 2019Article
- Glycosaminoglycans and Their Mimetics.Molecules (Basel, Switzerland) · 2016Article
- Research progress on the relationship between nanocrystals and calcium oxalate stones.Science progressReview
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis research aims to study the influences of heparin (HP) on the aggregation of nano calcium oxalate monohydrate (COM) and nano calcium oxalate dihydrate (COD) with mean diameter of about 50 nm.
methodThe influences of different concentrations of HP on the mean diameter and Zeta potential of nano COM and nano COD were investigated using a nanoparticle size Zeta potential analyzer.
resultsHP could be adsorbed on the surface of nano COM and nano COD crystals, leading to an increase in the absolute value of Zeta potential on the crystals and an increase in the electrostatic repulsion force between crystals. Consequently, the aggregation of the crystals is reduced and the stability of the system is improved. The strong adsorption ability of HP was closely related to the -OSO3- and -COO- groups contained in the HP molecules. X-ray photoelectron spectroscopy confirmed the coordination of HP with Ca2+ ions of COM and COD crystals.
conclusionHP could inhibit the aggregation of nano COM and nano COD crystals and increase their stability in aqueous solution, which is conducive in inhibiting the formation of calcium oxalate stones.
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Registered trials
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